Kinds Of Wounds Research Articles

Study on the Effect of Essence and Extract of Thymus caramanicus Jalas on the Process of Oral Wound Healing in Rats

Oral ulcers are the most prevalent diseases of the oral cavity. Various factors may cause occurrence of such kinds of wounds, such as Physical and Chemical Trauma, Microbial infections, diseases or drug use, malignances and nonspecific causes. The aim of the present study is to determine the effect of Thymus caramanicus Jalas extract on healing Oral ulcers of white male rats. Present experimental clinical study was conducted on 48 adult male rats which were randomly divided into 3 groups of 16 rats, named Hydro-alcoholic extract, Essence and Control. On the first day of experiment a 2-millimeter wound was made by the application of a biopsy punch inside the mouth of each group. For the 1st group, the Hydro-alcoholic extract of T. caramanicus Jalas was used every 12 hours on a daily basis, for the 2nd group, the essence was used on the wound and, for the 3rd group, no drug was used. The progress of wounds healing was clinically examined on the 2nd, 4th, 6th and 8th days by the application of caliper, and histopathologic examination was conducted upon observation of the slides prepared. Data was analyzed by SPSS-21 software and ANOVA statistical test within the significance level of 0.05%. The results showed a significant decrease in the clinical size of the wound in extract group in comparison with control group on the 8th day. The average size of clinical ulcers on the 2nd day was similar in both groups. Furthermore, on the 6th and the 8th days, a significant decrease was observed in the size of the ulcers in extract group in comparison with the essence group (P<0.05). Results of the present study showed that the extract of T. caramanicus Jalas causes improvement in the process of the oral ulcers healing in the rats.

Use of hyperbaric oxygenation for wound management

Hyperbaric oxygenation consists in exposing patients to increased gas pressures while inhaling pure oxygen. It involves the use of hyperbaric chambers that can double or triple gas pressure inside them. Hyperbaric oxygenation may be useful in different clinical situations, but mostly for the treatment of decompression syndrome. In the last decades, it has been used for the management of different kinds of wounds. Hyperbaric oxygenation not only increases the delivery of oxygen to damaged tissues, but also stimulates angiogenesis, collagen synthesis, stem cell migration and local immune response. Clinical trials that have addressed the use of hyperbaric oxygenation are difficult to compare due to their heterogeneity in terms of experimental design, kind of injuries involved and assessment of outcome. Even though, most studies support the concept that hyperbaric oxygenation accelerates the healing process.

The Way We Are Together Today: Identity and Relationships in Contemporary Societies

Abstract The last century has catapulted us into a world full of instability, uncertainty, and a sense of bewilderment. The financial-economic crisis has been added to our difficulties, further polluting our environment, our relationships, our feelings, our wounds. Pre-cariousness, lack of work and of a vision for the future have been added to our sense of emptiness and disorientation. Hope has given way to darkness. We are immersed in the crisis. The feeling of tranquillity and security that we desire is fading, far away, and even forgotten. We are poised upon unstable ground, which makes us tremble and amplifies our need for stability and support. The single person favours self control and mastery, retiring narcissistically into him or herself and refusing help from anyone, not accepting any kind of wound or fragility. Behind these widespread attitudes lies the myth of total independence and of self sufficiency. Psychological and psychotherapeutic disciplines bring a change, within this context, towards a “relational turning point”, discovering in the dynamics of reciprocity the source of individual wellbeing, balance in relationships, and a sense of belonging to a community. The connection with another person makes it possible to build up a sense of oneself where multiplicity and unity, difference and belonging, individual and community coexist. Individuality and belonging are no longer opposed to one another, causing irresolvable conflict in the development of the self, but thanks to reciprocity, to the capacity of self giving and to ethics, they can be fully integrated and contribute to the daily activities, both in the individual and collective dimension, of each person.

Wound management in veterinary practice

ABSTRACT:Wound management is a wide-ranging topic with a variety of methods available to treat the different kinds of wound that are seen in veterinary practice. Aspects that are covered in this article include different types of wound, the wound healing process and the methods and products available to assist with the process of wound healing.

Stromal vascular fraction improves deep partial thickness burn wound healing

ObjectiveThe practice of early burn wound excision and wound closure by immediate autologous skin or skin substitutes is the preferred treatment in extensive deep partial and full-thickness burns. To date there is no proven definite medical treatment to decrease burn wound size and accelerate burn wound healing in modern clinical practice. Stromal vascular fraction is an autologous mixture that has multiple proven beneficial effects on different kinds of wounds. In our study, we investigated the effects of stromal vascular fraction on deep partial-thickness burn wound healing. MethodsIn this study, 20 Wistar albino rats were used. Inguinal adipose tissue of the rats was surgically removed and stromal vascular fraction was isolated. Thereafter, deep second-degree burns were performed on the back of the rats by hot water. The rats were divided into two groups in a randomized fashion. The therapy group received stromal vascular fraction, whereas the control group received only physiologic serum by intradermal injection. Assessment of the burn wound healing between the groups was carried out by histopathologic and immuno-histochemical data. ResultsStromal vascular fraction increased vascular endothelial growth factor, proliferating cell nuclear antigen index, and reduced inflammation of the burn wound. Furthermore, vascularization and fibroblastic activity were achieved earlier and observed to be at higher levels in the stromal vascular fraction group. ConclusionsStromal vascular fraction improves burn wound healing by increasing cell proliferation and vascularization, reducing inflammation, and increasing fibroblastic activity.

Formulation of a new phenytoin-containing mucoadhesive and evaluation of its healing effects on oral biopsy ulcers

Background and Objective: Several studies have shown the wound healing effect of topical phenytoin, which is applied by its effect on connective tissue intracellular matrix. However, there are still some controversies about its effect on various kinds of wounds, especially in the experimental models. This study is aimed at evaluating the effect of mucoadhesive paste compared to phenytoin mucoadhesive paste on wound healing after oral biopsy. Material and Methods: In this double blind randomized clinical trial, 20 patients who were eligible for oral biopsy were allocated into the case and control groups. After the biopsy, patients having ulcers ranging between one and two centimeters were treated by simple or 1% phenytoin mucoadhesive paste. All patients were instructed to apply their paste at least three times a day for five days after the biopsy. Patients in both groups were evaluated every other day for size of the ulcer, degree of pain and diameter of the inflammatory halo. Statistical analysis was done using SPSS software and Mann-Whitney test. Results: After the second and third appointments, it was observed that the rate of wound healing and decrease in the size of the ulcers were significantly quicker in the treatment group (p = 0.001 and p = 0.003 respectively) and the patients in the phenytoin group reported less pain. Diameter of the inflammatory halo was not significantly different between two groups. Conclusion: Applying 1% phenytoin mucoadhesive paste on biopsy ulcers resulted in accelerated wound healing and decrease in pain, but had no effect on the diameter of the inflammatory halo.

The clinical application of superficial circumflex iliac artery flaps

To investigate the clinical application of pedicled superficial circumflex iliac artery (SCIA) flaps in Burns and Plastic Surgery. 19 cases with skin and soft tissue defects were repaired with the Superficial circumflex iliac artery flaps. The defects located in the hand and forearm, the lower abdomen and perineal area, the radicle area of thigh, etc. Before the SCIA flaps were transfered to the recipient areas, 15 cases with different kinds of wounds were debrided thoroughly, 3 cases with scar were removed directly. The size of the flaps ranged from 3.0 cm x 4.5 cm to 26.0 cm x 22.0 cm, and the pedical was 5 cm to 7 cm in length. The flaps in the 18 cases survived completely. Skin necrosis in the distal end of the flap appeared in 1 case, and the wound healed after the second repair. The follow-up period rang from 3 to 18 months. The apperance and function of the hand or foot was satisfactory. Because the pedicled SCIA flaps can be obtain conveniently and contain sufficient blood-supply, so the flap is easy to survive and the flap can be designed in a large size. We believe it is an ideal method to use this flap to repair skin and soft tissue defects located in hands, forearms, the lower abdomen and perineal areas, the radicle area of thigh and so on.

Does Quiescence Exist in Subcutaneous Abscesses? A Case of a 10-Year-Old Abdominoplasty Abscess

Quiescence is the dormant state before the inevitable eruption of an infection. Several human diseases such as cancer may present with a relatively long period of inactivity, but soft tissue infections usually have a rapid progression. In this letter, we describe the rather uncommon clinical expression of an insidious subcutaneous abscess 10 years after abdominoplasty. It is our hope that this will be helpful in documenting this unique occurrence in the plastic surgery literature. A 61-year-old woman presented with tenderness in the infraumbilical region that was triggered after a blunt-force trauma (kick) in the abdomen 5 days before. Physical examination revealed normal periumbilical and abdominal scars (abdominoplasty sequelae), but the skin between the 2 scars was very firm and fixed to the underlying tissues, with associated localized inflammation (Figure 1). Apart from desquamation, no puncture point or other kind of wound was noted. The patient was a healthy woman and had no medical problems or treatment that could have compromised her immune response. Figure 1 Initial presentation. Note the skin deformation associated with desquamation and inflammation indicating an infectious subcutaneous collection. The patient had undergone an abdominoplasty 10 years before presentation that was complicated by a postoperative Staphylococcus aureus surgical site infection. The infection manifested an abscess of the infraumbilical region with no wound dehiscence; it was drained twice. No …

From “boys” to “men”? African and black masculinities, triangular desire, race, and subalternity in Charles Mungoshi’s short stories

This article looks at African and black men and masculinities, triangulated desire, race, and subalternity in Charles Mungoshi’s short story collections. It examines the negotiation of desire, and its interface and interplay with power relations and their negotiation in the colonial and postcolonial economies of domination and gender as depicted in the short stories. It uses the Gramscian concept of hegemony, Girard’s mimetic theory of triangular desire, and Sedgwick’s theory of gendered triangular desire, to examine these dynamics. It argues that colonial and postcolonial power and gender relations are negotiated through a complex interplay of desire that cannot all be accounted for by both Girard and Sedgwick’s models, necessitating their modification to deal with the complexity of desire in a colonial and postcolonial context. The short story collections examined span the colonial and postcolonial eras and these are Coming of the Dry Season (1981), Some Kinds of Wounds (1980), and Walking Still (1997).

Cutaneous wound closure materials: An overview and update

Introduction:On a daily basis, dermasurgeons are faced with different kinds of wounds that have to be closed. With a plethora of skin closure materials currently available, choosing a solution that combines excellent and rapid cosmetic results with practicality and cost-effectiveness can be difficult, if not tricky.Objectives:We aimed to review the available skin closure materials over the past 20 years and the scientific claims behind their effectiveness in repairing various kinds of wounds.Materials and Methods:The two authors independently searched and scrutinised the literature. The search was performed electronically using Pub Med, the Cochrane Database, Google Scholar and Ovid as search engines to find articles concerning skin closure materials written since 1990.Conclusion:Many factors are involved in the choice of skin closure material, including the type and place of the wound, available materials, physician expertise and preferences, and patient age and health. Evidence-based main uses of different skin closure materials are provided to help surgeons choose the appropriate material for different wounds.

‘L’écriture qui saigne’: Exile and wounding in the narratives of Nina Bouraoui and Linda Lê

This article offers a critical analysis of the articulation of wounds in two recent exile narratives: Nina Bouraoui’s Mes mauvaises pensées (2005) and Linda Lê’s In Memoriam (2007). Arguing for a new understanding of exile as a form of repetition compulsion, in which trauma is repeatedly revisited and restaged in writing, the article investigates the frequent references to different kinds of wounds, both literal and imagined, physical and psychical, which emerge from these experimental texts. The analysis focuses on two specific aspects: first, drawing on the theoretical work of Kathryn Robson and Cathy Caruth, which highlights the difficulty of articulating traumatic experience (and the wounds which result), it considers why these exile narratives so frequently resort to the use of such violent, bodily imagery; second, it investigates the notion of scriptotherapy in order to evaluate the very different accounts of the relationship between writing and the wounds of exile which emerge from these texts.

Immunomodulatory properties of medicinal maggots Lucilia sericata in wound healing process

The healing properties of medicinal maggots (larval stage of Lucilia sericata) are widely used in the chirurgical debridement of non-healing wounds including diabetic foot ulcers, venous and pressure ulcers, where classical approaches have failed. Several kinds of wounds are prone to complications coming out of a specific wound bed environment. There are multi-resistant bacterial species present, their pathogenic impact is multiplied by their ability to form a biofilm. Moreover, immunological events in chronic wounds differ from those in acute wounds. Non-healing wounds are cycled in the early inflammation phase with increased levels of inflammation attributes like inflammation cytokines and matrix metalloproteinases produced by inflammation phase cells. Application of larval therapy promotes progress in the healing process to the next stages involving tissue granulation and re-epithelisation. Larval debridement is an effective method of cleaning the wound of cell debris, necrotic tissue and bacterial load.This happens in a mechanical and biological manner, but the whole complex mechanism of the maggot healing activity is still not fully elucidated. Centuries of clinical practice brings noticeable proof of the maggots’ beneficial effect in wound healing management. This long history led to the investigation of the bioactive components of the larval body and its extracts in vitro. We introduce a review which describes the immunomodulation impact of maggot body components on the cellular and molecular levels of the wound healing process.

Hyperbaric oxygen and wound healing

Hyperbaric oxygen therapy (HBOT) is the use of 100% oxygen at pressures greater than atmospheric pressure. Today several approved applications and indications exist for HBOT. HBOT has been successfully used as adjunctive therapy for wound healing. Non-healing wounds such as diabetic and vascular insufficiency ulcers have been one major area of study for hyperbaric physicians where use of HBOT as an adjunct has been approved for use by way of various studies and trials. HBOT is also indicated for infected wounds like clostridial myonecrosis, necrotising soft tissue infections, Fournier's gangrene, as also for traumatic wounds, crush injury, compartment syndrome, compromised skin grafts and flaps and thermal burns. Another major area of application of HBOT is radiation-induced wounds, specifically osteoradionecrosis of mandible, radiation cystitis and radiation proctitis. With the increase in availability of chambers across the country, and with increasing number of studies proving the benefits of adjunctive use for various kinds of wounds and other indications, HBOT should be considered in these situations as an essential part of the overall management strategy for the treating surgeon.

Laser CO2 versus Radiotherapy in treatment of keloid scars

Keloids and hypertrophic scars are quite common diseases that can occur after any kind of wound and skin inflammation in predisposed individuals. Despite their benign nature, they can be aesthetically disabling and they are often accompanied by unpleasant symptoms such pain, burning and itching. Several approaches have been tried but most of them with poor results. Ablative fractional CO2 laser seems to be an encouraging approach in treatment of keloids and hypertrophic scars, not only for its efficacy, but also for its low harmfulness. Radiotherapy following surgical excision is commonly used to treat these scars, but an increased incidence of different kinds of cancer from radiation has been demonstrated in several cases. Compared to radiotherapy, the use of CO2 laser after surgical excision of keloids has shown great results with no recurrence and without the risk of carcinogenesis.

Clinical evidences, personal experiences, recent applications

Management of difficult wounds can be a complex, chal lenging and expensive task, especially for wounds showing a slow healing process. Topical negative pressure (TNP) therapy has greatly improved difficult wounds treatment. It allows to treat patient on an outpatient management, to reduce the complication rate with shorter hospital stay, to avoid frequent dressings with expensive advanced materials and allow a lower commitment of health professionals. Vacuum Assisted Closure ® (VAC ® ) system is a therapeutic device based on the administration of a controlled TNP introduced by Morykwas and Argenta in 1997. It is indicated in different kinds of wound, but clinical evidences are present only for few of them. In this work we summarize indications and recommendations for VAC ® therapy and we analyze the actual better choice of treatment based on evidences and personal experience in order to stimulate further studies. Finally we introduce recent applications of VAC ® system such as Prevena ® , VAC Instill ® and VAC Via ® . Prevena ® is a system based on TNP indicated in the management of closed wounds that present risk factors for dehiscence. VAC Instill ® is a system that allows to associate TNP and topical administration of solutions, such as antibiotics or disinfectants, to treat specific type of wounds. VAC Via ® is a device based on TNP, characterized by little dimension and a preset system that allow the treatment of little wounds for 7 d, with no impairment for the patient.

Od ontologii do etyki wydarzenia

Tekst stanowi próbę podwójnej lektury Deleuzjańskiej Logiki sensu jako, z jednej strony, ontologii niecielesnych wydarzeń, z drugiej zaś – etyki wzywającej do „bycia godnym tego, co nam się przydarza”. Ten pierwszy aspekt wiąże się z koniecznością przezwyciężenia fenomenologii i zrewidowania założeń filozofii transcendentalnej. Z kolei swoją etykę wydarzenia Deleuze rozwija, nawiązując do stoików i Nietzschego, a także pisarzy takich jak Bousquet, Lowry czy Fitzgerald. Opiera się ona na imperatywie afirmacji świata jako stawania się – afirmacji zarówno na płaszczyźnie albo powierzchni czystej myśli, jak i we własnym ciele, dla którego jednak oznacza to zawsze ranę, zagrożenie rozpadem.

Effect of hydrocolloid dressings decreased the skin wound infected rate of the I stage colostomy closure

Objective To evaluate the effectiveness of the hydrocolloid dressings decreased the skin wound infected rate of theI stage colostomy closure. Methods All of the forty-three patients with I stage colostomy closure were randomly divided into two groups, study group （24 cases） received the hydrocolloid dressing care, and control group （19 cases） received the 3L adhesive wound dressing care. The skin wound infected rate, average postoperative hospital stay, and average postoperative change dressings cost were noted and compared between the two groups. Resulta The skin wound infected rate of the Istage colostomy closure in study group were significantly less than control group （4. 16% vs 31.57% ,X2 =5.8 ,P 〈0. 05） ; the average hospital stay in study group were （6.03 ± 1.17）d,it was significantly less than that the control group （13.64 ± 4.09）d （t = -2. 173, P 〈0. 05 ） ; and the average postoperative change dressings cost in study group were significantly less than control group[（297.50 ±33.69）vs. （544.90 ±103.48）yuan, t =2.050,P〈0.05]. Conclusions Our study has demonstrated that the hydrocolloid dressings could decrease the skin wound infected rate, the average postoperative hospital stay, and the average postoperative change dressings cost of the I stage colostomy closure. It would provide a new technique that could be used to treat this kind of wounds with high risk of infection. Key words: Hydrocolloid dressing; Wound infection; Colostomy closure

Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review

BackgroundHyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear.MethodsWe undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing and adverse effects in patients with acute wounds. To detect all available randomized controlled trials (RCTs) we searched five relevant databases up to March 2010. Trial selection, quality assessment, data extraction, and data synthesis were conducted by two of the authors independently.ResultsWe included five trials, totaling 360 patients. These trials, with some methodologic flaws, included different kinds of wound and focused on different outcome parameters, which prohibited meta-analysis. A French trial (n = 36 patients) reported that significantly more crush wounds healed with HBOT than with sham HBOT [relative risk (RR) 1.70, 95% confidence interval (CI) 1.11–2.61]. Moreover, there were significantly fewer additional surgical procedures required with HBOT (RR 1.60, 95% CI 1.03–2.50), and there was significantly less tissue necrosis (RR 1.70, 95% CI 1.11–2.61). In one of two American trials (n = 141) burn wounds healed significantly quicker with HBOT (P < 0.005) than with routine burn care. A British trial (n = 48) compared HBOT with usual care. HBOT resulted in a significantly higher percentage of healthy graft area in split skin grafts (RR 3.50, 95% CI 1.35–9.11). In a Chinese trial (n = 145) HBOT did not significantly improve flap survival in patients with limb skin defects.ConclusionsHBOT, if readily available, appears effective for the management of acute, difficult to heal wounds.

Wound care by district nurses at primary healthcare centres: a challenging task without authority or resources

There is a lack of studies that describes how district nurses experience the care they provide in connection with wound care. The aim of this study was therefore to describe district nurses experiences of their nursing actions when treating patients with different kinds of wounds at primary healthcare centres and in the home care in order to increase understanding of this kind of care. A qualitative, descriptive study was conducted, with interviews of eight district nurses. Data were analysed using qualitative content analysis. Three themes and nine sub-themes were identified. The first theme included two sub-themes which revealed that in performing wound care district nurses feel responsible for administering wound care, and they feel confident in making independent assessments. The second theme included three sub-themes which revealed that district nurses endeavour to assess all aspects of their patient's situation and to maintain continuity in both their contact with the patient and the treatment. A treatment plan for wound care and regular reports were identified as being important in collaboration with other healthcare professionals. District nurses wanted their own procedure for referral to facilitate the patient's direct contact with a dermatologist. The third theme included four sub-themes which revealed difficulties associated with ambiguous organisation. Lack of time led to the dressing of wounds being delegated to nursing assistants. Limited access to treatment rooms and equipment made wound care difficult and inefficient. Wound care in the home care was regarded as challenging due to the lack of equipment, and poor lighting, ergonomics and hygiene. The results of this study thus identified the aspirations of district nurses to provide expert wound care while working independently. However, these aspirations were aggravated by organisational shortcomings, such as a lack of authority and the resources required to carry out their nursing actions optimally.

Histological Study of Open Wound Healing with a Light Cure Instrument

Introduction: In the present study, the effects of light cure on wound healing of mice’s skin with complete thickness were studied. Materials and Methods: Forty male mice of NMRI race were placed randomly into two groups of examination and control. Under aseptic and unconscious conditions, a circular wound of 6 mm width with complete thickness of skin was made on the back of each mice. The surgery day was established as day zero. Blue light of wavelength 420-500 nm from a light cure instrument was shined onto all the mice from the first day. Over the 3rd, 7th, 10th, 15th and 21st days after curing, four kinds of wound and healthy skins were taken from each mice. The practical procedures of general histology were applied on the samples, then slices of 5 micron thickness were taken from them and finally, they were colored with Hematoxline Eosin. The cell population of wound bed including fibroblast cells, macrophages, neutrophils and endothelia of vessels were studied. Results: The examination group showed significantly increased fibrosis and decreased inflammation (p≤0.05). Conclusion: Halogen blue light (light cure) causes significant early open wound healing of skin with complete thickness.