A novel designed Fano system using metal-dielectric-metal (MDM) configuration is proposed and numerically evaluated via finite element method (FEM). At the same time, the formation mechanism of Fano resonance is explored based on numerical simulations. Moreover, the standing wave theory and the temporal coupled-mode theory (CMT) are utilized to investigate the resonant phenomenon. The system is constructed by the tooth cavity connected into straight waveguide and a circular ring resonator with nanodots (CRRN). The simulation results indicate that the CRRN supports the two kinds of resonant modes: TM2 and like-TM2 mode, whose distribution of field patterns (the resonant point related to like-TM2 mode) can be flexibly controlled by the position of nanodot (the number and thickness of the nanodots). With regard to the excited dual Fano resonances, their emergence or disappearance can be tuned by nanodot position, and the independent tunability of FR2 can be realized by adjusting nanodot’s number and thickness. In addition, the Fano system with a sensing performance of 942 nm RIU−1 has been demonstrated, which can be great promising for detecting glucose concentration. In summary, the proposed Fano structure may provide a feasible scheme to flexibly manipulate the dual Fano resonances and detect glucose concentration.