Among the existing techniques to mitigate the problem of contamination in the indoor environment, photocatalytic technology is considered to be the most promising solution in terms of effectiveness and cost. To that end, in the frame of the LIFEVISIONS project, a novel photocatalytic powder (photo-powder) was mixed in paints’ matrix, producing a photocatalytic building material (photo-paint) able to improve indoor air quality (IAQ), upon its application, without downgrading paint physical properties. As a result, of IAQ improvement, less energy will be needed from ventilation systems, addressing not only health issues related to air quality but also energy reduction targets. Many powder formulae were synthesized using different synthetic pathways, concentration of dopants, and TiO2 particles’ size. They were tested in a photocatalytic reactor (lab-scale tests), according to CEN TS 16980-1:2017, under visible light and the results showed that the most promising photocatalytic performance degrades 85.4% and 32.4% of nitrogen oxide (NO) and toluene, respectively. This one was used for the production of two different kinds of paints, organic (with organic binder) and inorganic (with potassium silicate binder), in an industrial scale. Both were tested in the Demo Houses’ prototype demonstrator (real-scale tests) with an ultimate scope to estimate their effectiveness to degrade air pollutants under real-world conditions. In addition, the reduced energy consumption as a result of less ventilation needs was calculated in Demo Houses. More specifically, the energy reduction based on simulation results on Demo Houses was more than 7%. Although lab-scale tests showed better photocatalytic performance than the real scale, the efficiency of the paints under a more complicated environment was very promising.