During cage keeping of minks, one of the important problems is the high level of stress of animals caused by a number of factors: microclimate, feeding, low locomotion, etc. High stress levels have a negative effect on the physiological status of animals and can lead to serious pathological changes. Stress reactions activate neuroendocrine mechanisms, while at the same time mobilizing the body’s protective functions and inhibiting the processes of growth, development and reproductive function. The level of cortisol in the body clearly shows the degree of its stress, since the adrenal glands are responsible for the regulation of the stress response and are a source of catecholamines and corticosteroids. The experiment was carried out on the young mink males. Under observation were 60 animal analogues. Blood was taken from 6 animals from each group at the beginning and at the end of the experiment. An autopsy of 6 male minks from each group was performed to assess the condition of the internal organs. The level of cortisol in male minks at the beginning of the experiment was increased (more than 700 nmol/l). It is shown that with the introduction of the Emidonol 20%, the stress of animals decreases, in comparison with the control. The adrenal mass in the control group was 29% higher than in the group where the additive was used. The cortisol level at the end of the experiment in minks that were the additive was input (541 nmol / L (p≤0,05) significantly decreased in comparison with the control (815 nmol / L). Also, a decrease in the level of stress may indirectly be indicated by a decrease in heart and liver (p≤0,05) and kidney mass, compared with the control group.