The zeroth coefficient polynomial is a one variable polynomial contained in the HOMFLYPT polynomial. In this paper, we give a basic computation of the zeroth coefficient polynomial of a 2-cable knot. In particular, we compute the zeroth coefficient polynomials of the 2-cable knots of the Kanenobu knots. It is known that the Kanenobu knots have the same HOMFLYPT polynomial and the same Khovanov–Rozansky homology. As a result, we distinguish the Kanenobu knots completely. Moreover, we estimate the braid indices of the Kanenobu knots.