Key Chiral Intermediates Research Articles

A stereocontrolled synthesis of the key intermediate of (+)-thienamycin from ( [formula omitted])-(−)-3-hydroxybutyric acid esters

The chiral key intermediate of (+)-thienamycin is synthesized in a stereocontrolled manner from ( R )-(−)-3-hydroxybutyric acid esters.

Total synthesis of leukotriene (+)-LTB4 from D-mannitol1

A total convergent synthesis of leukotriene (+)-LTB4 has been carried out via two enantiomerically pure α-hydroxyaldehydes,chiral key intermediates both obtained from D-mannitol and connected at a four carbon atoms interval by Wittig reactions.

Mevinic acids and analogues: preparation of a key chiral intermediate

The preparation of methyl 3-0-tert-butyldiphenylsilyl-2,4-dideoxy-β- D - erythro - hexopyranoside, a key chiral intermediate for mevinic acids, and its elaboration into four mevinate analogues are described.

ChemInform Abstract: TOTAL SYNTHESIS OF ALL EIGHT STEREOISOMERS OF α‐TOCOPHERYL ACETATE. DETERMINATION OF THEIR DIASTEREOISOMERIC AND ENANTIOMERIC PURITY BY GAS CHROMATOGRAPHY

AbstractKondensation der chiralen Chroman‐Derivate (I) bzw. (VI) mit den nach Literatur aufgebauten chiralen Grignard‐Reagenzien (II) in Gegenwart von Li2CuCl4 liefert die stereoisomeren α‐Tocopherylbenzylether (III) bzw. (VII), deren Hydrogenolyseprodukte, die α‐Tocopherole (IV) bzw. (VIII), zu den Acetaten (V) bzw. (IX) umgesetzt werden, die in hoher chemischer und stereoisomeren Reinheit erhalten werden.