Ketone Compounds Research Articles

Atmospheric Pollutant Emission Characteristics from the Cooking Process of Traditional Beijing Roast Duck

As one of the characteristics of traditional food in Beijing, there is a significant difference between roast duck and other foods in the cooking process, in that fruit trees are used as fuel in the former. However, system research about the emission characteristics of this food source has not been done domestically. In order to grasp such food source emission characteristics and provide technical basis for pollution control, we selected the representative roast duck restaurant in Beijing and studied the emission characteristics of atmospheric pollutants in the cooking process of roast duck. The results showed that the emission concentrations of cooking fumes, particulate matter, volatile organic compounds (VOCs), and aldehyde and ketone compounds were (0.74±0.45), (15.32±7.93), (7.60±3.41), and (1.22±0.59) mg·m-3, respectively. The emission concentration of particulate matter was much higher than that of cooking fumes. The VOC component composition was very complex, containing alkanes, alkenes, aromatic hydrocarbons, and oxygen VOCs, such as aldehydes, ketones, alcohols, ester compounds, and halogenated hydrocarbons, with the highest concentrations of 3-methylfuran, ethanol, and methyl acetate. The main components of aldehyde and ketone compounds were acetaldehyde, formaldehyde, and acrolein, of which C1-C3 compounds were 72.27%.

Comparison of Four Extraction Methods, SPME, DHS, SAFE, Versus SDE, for the Analysis of Flavor Compounds in Natto

Natto is a kind of traditional fermentation food. Organic soybean of china northeast was selected as the material to produce natto according to the condition optimized before. Four extraction methods (SAFE (solvent-assisted flavor evaporation), SDE (simultaneous distillation and extraction), SPME (solid phase microextraction), and DHS (dynamic headspace sampling)) were applied to extract the volatile compounds of natto. Aroma compounds were separated and analyzed with gas chromatography-olfactometry-mass spectrometry (GC-MS/O) of DB-5 and DB-Wax capillary columns. Seventy-seven compounds were identified by four extraction methods. Among them, 42, 23, 31, and 36 compounds were identified by SPME, DHS, SDE, and SAFE, respectively. SAFE and SDE had a better extraction effect on ester, ether, and aromatic compounds, while SPME and DHS could extract ketone, acid, and pyrazine compounds effectively. SPME was fit for the extraction of natto aroma compounds. These compounds included 14 ketones, 9 alcohols, 4 aldehydes, 6 acids, 4 sulfur compounds, 5 esters, 8 pyrazines, 19 aromatics, and 8 others. Fourteen compounds were identified as key aroma compounds in natto, including 2,3-butanedione, 5-methyl-2-hexanone, 3-hydroxy-2-butanone, 2-nonanone, furaldehyde, acetic acid, 2-ethyl butyric acid, ethyl acetate, 2,5-dimethylpyrazine, 2,3,5-trimethylpyrazine, 3,5-dimethyl-2-ethylpyrazine, 2,3,5,6-tetramethylpyrazine, 2,3,5-methyl-6-ethylpyrazine, and benzaldehyde. Pyrazine was the important aroma compound with the high FD (flavor dilution) value in natto.

Rh(III)-catalyzed C−H alkylation of indolines with enones through conjugate addition and protonation pathway

The rhodium(III)-catalyzed C−H alkylations of indolines with enones and enals is described. This reaction can proceed through 1,4-conjugate addition and protonation process providing β-indolinic ketone compounds, which are known to be crucial scaffolds of biologically active compounds.

Allyl‐Palladium‐Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone α,β‐Vicinal Difunctionalization

AbstractThe telescoping of allyl‐palladium catalyzed ketone dehydrogenation with organocuprate conjugate addition chemistry allows for the introduction of aryl, heteroaryl, vinyl, acyl, methyl, and other functionalized alkyl groups chemoselectively to a wide variety of unactivated ketone compounds via their enone counterparts. The compatibility of the dehydrogenation conditions additionally allows for efficient trapping of the intermediate enolate with various electrophiles. The utility of this approach is demonstrated by comparison to several previously reported multistep sequences.

Allyl-Palladium-Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone α,β-Vicinal Difunctionalization.

The telescoping of allyl-palladium catalyzed ketone dehydrogenation with organocuprate conjugate addition chemistry allows for the introduction of aryl, heteroaryl, vinyl, acyl, methyl, and other functionalized alkyl groups chemoselectively to a wide variety of unactivated ketone compounds via their enone counterparts. The compatibility of the dehydrogenation conditions additionally allows for efficient trapping of the intermediate enolate with various electrophiles. The utility of this approach is demonstrated by comparison to several previously reported multistep sequences.

Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1.

Overexpression of peptidyl-prolyl cis/trans isomerase, NIMA interacting‑1 (Pin1) is a significant marker of the occurrence and development of tumors. In the present study, the imidazoline ketone herbicide imazamethabenz was investigated as a potential antitumor drug by inhibiting Pin1. Molecular docking and enzyme activity tests verified, for the first time, that the imidazoline ketone compound imazamethabenz effectively inhibited Pin1 invitro. MTT assays, western blotting, wound healing assay and Matrigel invasion assays revealed that imazamethabenz induced apoptosis and inhibited migration and invasion of the breast cancer cell line MCF‑7, which overexpresses Pin1, by inhibiting the Pin1‑mediated signaling pathway involving vascular endothelial growth factor and matrix metalloproteinase9. These findings indicated that imazamethabenz offers potential applications for the treatment of tumors as a Pin1 inhibitor.

Vibrational Probes: From Small Molecule Solvatochromism Theory and Experiments to Applications in Complex Systems.

The vibrational frequency of a chosen normal mode is one of the most accurately measurable spectroscopic properties of molecules in condensed phases. Accordingly, infrared absorption and Raman scattering spectroscopy have provided valuable information on both distributions and ensemble-average values of molecular vibrational frequencies, and these frequencies are now routinely used to investigate structure, conformation, and even absolute configuration of chemical and biological molecules of interest. Recent advancements in coherent time-domain nonlinear vibrational spectroscopy have allowed the study of heterogeneous distributions of local structures and thermally driven ultrafast fluctuations of vibrational frequencies. To fully utilize IR probe functional groups for quantitative bioassays, a variety of biological and chemical techniques have been developed to site-specifically introduce vibrational probe groups into proteins and nucleic acids. These IR-probe-labeled biomolecules and chemically reactive systems are subject to linear and nonlinear vibrational spectroscopic investigations and provide information on the local electric field, conformational changes, site-site protein contacts, and/or function-defining features of biomolecules. A rapidly expanding library of data from such experiments requires an interpretive method with atom-level chemical accuracy. However, despite prolonged efforts to develop an all-encompassing theory for describing vibrational solvatochromism and electrochromism as well as dynamic fluctuations of instantaneous vibrational frequencies, purely empirical and highly approximate theoretical models have often been used to interpret experimental results. They are, in many cases, based on the simple assumption that the vibrational frequency of an IR reporter is solely dictated by electric potential or field distribution around the vibrational chromophore. Such simplified description of vibrational solvatochromism generally referred to as vibrational Stark effect theory has been considered to be quite appealing and, even in some cases, e.g., carbonyl stretch modes in amide, ester, ketone, and carbonate compounds or proteins, it works quantitatively well, which makes it highly useful in determining the strength of local electric field around the IR chromophore. However, noting that the vibrational frequency shift results from changes of solute-solvent intermolecular interaction potential along its normal coordinate, Pauli exclusion repulsion, polarization, charge transfer, and dispersion interactions, in addition to the electrostatic interaction between distributed charges of both vibrational chromophore and solvent molecules, are to be properly included in the theoretical description of vibrational solvatochromism. Since the electrostatic and nonelectrostatic intermolecular interaction components have distinctively different distance and orientation dependences, they affect the solvatochromic vibrational properties in a completely different manner. Over the past few years, we have developed a systematic approach to simulating vibrational solvatochromic data based on the effective fragment potential approach, one of the most accurate and rigorous theories on intermolecular interactions. We have further elucidated the interplay of local electric field with the general vibrational solvatochromism of small IR probes in either solvents or complicated biological systems, with emphasis on contributions from non-Coulombic intermolecular interactions to vibrational frequency shifts and fluctuations. With its rigorous foundation and close relation to quantitative interpretation of experimental data, this and related theoretical approaches and experiments will be of use in studying and quantifying the structure and dynamics of biomolecules with unprecedented time and spatial resolution when combined with time-resolved vibrational spectroscopy and chemically sensitive vibrational imaging techniques.

Identification of flavor compounds in rambutan seed fat and its mixture with cocoa butter determined by SPME-GCMS

Rambutan (Nephelium opossum L) is one of the most important tropical fruits that is originally found in Malaysia, Thailand, Philippines, Vietnam, Borneo and other countries in this region. The industrial processing of this fruit produces seeds and peels as waste materials. The aim of this work was to determine the flavor active compounds of rambutan seed fat (RSF) and its mixtures with cocoa butter (CB) after fermentation 6days and roasting at 150°C for 30min in term of ester, alcohol, hydrocarbon, carboxylic acid, aldehyde, ketone and pyrazine compounds. The result showed total ester flavoring compounds increased in the range of 10.59%–16.49% in the RSF mixtures as compared to CB. Alcoholic flavoring compounds also found in the range of 10.03%–23.15% of the total flavor in CB and RSF mixtures respectively. The most important flavoring compounds, Pyrazine, 2,6-dimethyl (1.42% and 2.01%), Pyrazine, 2-ethyl-6-methyl (0.67% and 0.62%), Pyrazine, trimethyl (5.10% and 5.22%), Pyrazine, tetramethyl (14.34% and 14.72%), 2-Acetyl-3,5-dimethylpyrazine (0.56% and 0.45%), 2-Isoamyl-6-methylpyrazine (0.34% and 0.34%) and Pyrazine, 2-butyl-3,5-dimethyl (0.34% and 0.27%) estimated in CB and RSF mixtures respectively. Rambutan seed fat up to 20% can be used with cocoa butter as a potential ratio of CB and RSF for the application in chocolate manufacturing as a cocoa butter alternative to improve and get the best quality aroma in final products.

Identification of cuticular compounds collected from Callosobruchus rhodesianus (Pic) eliciting heterospecific mating behavior with male Callosobruchus maculatus (F.)

Callosobruchus seed beetles (Coleoptera: Chrysomelidae: Bruchinae) are pests of stored legumes in tropical and subtropical regions. The cuticular surfaces of female Callosobruchus seed beetles contain a contact sex pheromone, which elicits copulatory behavior in congeneric males. Asymmetric cross-copulatory behavior was observed between C. maculatus and C. rhodesianus despite considerable differences in the structures of their contact sex pheromones. C. maculatus uses dicarboxylic acid, whereas C. rhodesianus uses two ketone compounds in conjunction with similar synergistic cuticular hydrocarbon blends in both cases. Male C. maculatus exhibited copulatory behavior with females of both C. maculatus and C. rhodesianus, but male C. rhodesianus mated only with congeneric females. To establish the reasons for the asymmetric cross-copulatory behavior of C. maculatus, we tried to identify the heterospecific mate-eliciting compounds in the cuticles collected from virgin C. rhodesianus females. The compounds were fractionated using acid-base partitioning and chromatography techniques and then assayed for their ability to elicit male copulatory activity. Gas chromatography–mass spectrometry (GC–MS) analysis of the active acidic fraction revealed the presence of three dicarboxylic acids: 2-methylsuberic acid (2-methyloctanedioic acid) (1), 3-methylsuberic acid (3-methyloctanedioic acid) (2), and nonanedioic acid (3). The synergistic effect was compared using synthetic standards and natural hydrocarbons. When the compounds were combined with the natural hydrocarbons, compounds 1 and 2 elicited significant copulatory activity in male C. maculatus. In contrast, relative to the effect of natural hydrocarbons alone, compound 3 did not exhibit significant copulatory activity when combined with natural hydrocarbons. The results demonstrated that the asymmetric cross-copulatory behavior of C. maculatus is induced by the presence of contact sex pheromone analogs on the cuticular surface of female C. rhodesianus. In combination with previous reports, although a saltational evolution was hypothesized for the contact sex pheromones of C. rhodesianus, this species continues to produce dicarboxylic acids functioning as pheromones that are structurally similar to those secreted by closely related species.

Study on Carbonyl Emissions of Diesel Engine Fueled with Biodiesel

Biodiesel is a kind of high-quality alternative fuel of diesel engine. In this study, biodiesel and biodiesel/diesel blend were used in a single cylinder diesel engine to study the carbonyl emissions. The result shows that carbonyl pollutants of biodiesel and biodiesel/diesel blend are mainly aldehyde and ketone compounds with 1–3 carbon atoms, and formaldehyde concentration is higher than 80% of the total carbonyl pollutants for biodiesel. The formaldehyde concentration peak is reduced with the increase of intake temperature (T), intake pressure (P), and exhaust gas recirculation (EGR) ratio and increased with the increase of compression ratio (ε). When excess air coefficient (λ) is lower than 1.7, the formaldehyde concentration is increased with the increase of excess air ratio. When λ is higher than 1.7, the formaldehyde concentration is reduced with the increase of excess air ratio. The dilution of air can reduce formaldehyde concentration in the premixed flame of diesel effectively; however, it has less effect on biodiesel. Among the fuel pretreatment measures of adding hydrogen, CO, and methane, the addition of hydrogen shows the best effect on reducing formaldehyde of biodiesel.

Key volatile compounds in red koji-shochu, a Monascus-fermented product, and their formation steps during fermentation.

Red koji, which refers the solid culture grown koji mold on the steamed rice, is one of the ingredients of Asian fermented foods including the Japanese spirit shochu. This study was aimed at elucidating the characteristic flavor and key volatile compounds of red koji-shochu as well as the mechanism of their formation. Sensory evaluation showed that red koji-shochu has the distinctive flavors cheese, sour, milky, and oily. Fifteen key volatile compounds of red koji-shochu were identified by gas chromatography-mass spectrometry and high-performance liquid chromatography, and by comparison between red koji-shochu and white koji-shochu, as another typical shochu. The mash analysis revealed that ketone compounds and short-chain acids derive from red koji. Furthermore, although other key compounds were produced by yeast, it is highly likely that their concentrations were affected directly or indirectly by the high activities of protease and lipase in red koji.

Oxygen concentration and conversion distributions in a layer-by-layer UV-cured film used as a simplified model of a 3D UV inkjet printing system

Three-dimensional (3D) ultraviolet (UV) inkjet printers represent a versatile technology for creating complex functional structures. During their operation, 3D objects are formed by repeating cycles of drawing a UV-curable resin with inkjet nozzles and then solidifying it with UV irradiation. In this study, the activity performed by a 3D UV inkjet printer was simulated by spin casting a 33µm thick layer of UV-curable resin (containing diurethanedimethacrylate and 1-hydroxycyclohexyl phenyl ketone compounds mixed at a weight ratio of 99:1) onto a Si wafer followed by photopolymerization for 2s at a UV irradiation of 10mWcm−2. Afterwards, the second resin layer with a thickness of 33µm was spun-cast onto the first layer and photopolymerized under the same conditions. The conversion distribution of C=C bonds in the UV-curable resin was investigated via confocal laser Raman microscopy and numerical calculations, which took into account the kinetics of photopolymerization and oxygen inhibition reactions. The confocal laser Raman microscopy technique provided a unique distribution of the C=C bond conversion across the film depth. Thus, the conversion magnitude at a depth of 0µm was zero and increased to 0.2 at 6µm. Afterwards, the slope of the conversion distribution plot became moderate until the conversion reached the value of 0.43 at a film depth of 28µm. Between the film depths of 28 and 38µm, the conversion remained constant with a variation not exceeding 0.03. After that, the conversion value increased again, reaching the magnitude of 0.48 at a depth of 50µm and remained constant in the region between 50 and 56µm (with a variation not exceeding 0.04). At higher depths, the graph slope became moderate again, and the conversion value increased gradually to 0.51 at 66µm, after which the silicon wafer was reached. As a result, two different plateaus were observed on the conversion distribution plot: between 28 and 38µm and between 50 and 56µm (the corresponding conversion variation in these regions was below 0.05). The obtained experimental data were in good agreement with the results of numerical calculations, which attributed the existence of the two plateaus on the plot of the C=C bond conversion distribution to the formation of an oxygen-lean point. In addition, the effects of the UV intensity, irradiation time, lamination time, photoinitiator concentration, and concentration of dissolved oxygen on the oxygen concentration and conversion distributions across the depth direction have been examined. The obtained results revealed that the increases in the UV intensity, irradiation time, and photoinitiator concentration as well as the decrease in the initial dissolved oxygen concentration effectively increased the conversion of C=C bonds in the resin film and decreased the thickness of an unpolymerized layer.

Classification and Analysis of Dissolved Organic Matter in 2-Buternal Manufacture Wastewater

The dissolved organic matters from 2-buternal manufacture wastewater were fractionated into seven fractions by ultra-filtration membrane separation. The amounts and structural compositions of organic compounds in different molecular weight ranges were characterized by dissolved organic carbon (DOC), ultraviolet spectrum (UV), Fourier transform infrared spectrometer (FT-IR) and gas chromatography with mass spectrometry (GC-MS). The results showed that the fraction of molecular weight less than 1×103 had the largest proportion in the wastewater, and occupied 88.57% of the DOC. There were 27 kinds of compounds qualitatively analyzed by GC-MS, mainly including aldehyde, ketone, ester, alcohol, phenol, organic acid, alkane and other heterocyclic compounds. The proportions of compounds of peak area accounting for total peak area of organic matters were 6.9%, 5.3%, 35.4%, 13.2%, 4.6%, 0.4%, 1.7% and 16.8% respectively, adding up to 84%. The analysis of UV and FT-IR demonstrated that the spectral absorptive characteristics of organic compounds from different fractions were not significantly different. The fractions contained carbonyls, hydroxys and aromatic compounds, which was consistent with the qualitative analysis of GC-MS. The results of this study provide an important guidance for the development and optimization of 2-buternal manufacture wastewater treatment process.

Effect of sporopollenin microparticle incorporation into the hexyl methacrylate-based monolithic columns for capillary liquid chromatography

ABSTRACTSporopollenin microparticles have been prepared form Lycopodium clavatum spores, defatted and incorporated into a porous methacrylate polymer monolith to enhance liquid chromatographic performance of different sets of small neutral molecules. A stable suspension between sporopollenin microparticles and porogenic solvents composed of 1-propanol and 1,4-butandiol has proved before preparation, and seven compositions with increasing sporopollenin microparticles were prepared inside fused silica tubing. After optimizing of the preparation conditions, the structure of the stationary phase was characterized by scanning electron microscopy, surface area analysis, thermodynamic study, short- and long-term precision, and hydrodynamic properties including mechanical stability, porosity, and permeability. The columns were successfully applied to improve the separation efficiency of different mixtures using capillary liquid chromatography. Addition of very small amount of sporopollenin microparticles to the methacrylate mixture enhanced the column efficiency from 3 to 5 times for ketonic and phenolic compounds and reduced the retention with the corresponding better resolution and peak shapes for all studied compounds.

Fuel Characterization and Thermogravimetric Analysis of Melon (Citrullus colocynthis L.) Seed Husk

The thermochemical fuel properties of melon seed husk (MSH) were characterized to examine its solid biofuel (SBF) potential for future bioenergy utilization. MSH is a cheap, abundant and renewable source of lignocellulosic waste generated from the extraction of vegetable oil from melon seeds. Thermochemical characterization was examined by proximate, ultimate, and thermogravimetric (TG-DTG) analyses, as well as Fourier transform infra-red (FT-IR) spectroscopy. The results showed that MSH exhibits significant volatile matter, fixed carbon, carbon and low nitrogen, sulphur and ash content with a heating value (HHV) of 19.02 MJ/kg. FT-IR analysis indicated functional groups for aliphatic, ester, ketone, alcohol, and aromatic compounds. Thermal decomposition of MSH occurred in three stages: drying (303–448 K), devolatization (448–673 K) and char degradation (673–1073 K).

Biomass Pyrolysis of Helianthus annuus Stems: Qualitative and Quantitative Study Based on Py-GC/MS

The pyrolytic product vapor of Helianthus annuus stems was analyzed by Pyrolysis–gas chromatography–mass spectrometry (Py-GC/MS) using the internal standard (ISTD) method with different pyrolysis temperatures and times. 1,3,5-tri-tert-butylbenzene (TTBB) was found to be the best ISTD chemical in this study. Scanning electron microscopy (SEM) revealed that, for the solid-state product, the pores and mesh structure gradually increased along with the pyrolysis temperatures and time. Sintering and porous destruction were observed at a lower pyrolysis temperature (600 °C) with longer time (0.5 min). The pyrolysis vapors contained small gas molecules such as CO2 as well as complex organic compounds, mainly alcohols, esters, acids, aldehydes, ketones, aromatic compounds, etc. In these products, aldehyde, ketone, and aromatic compounds were the main biochemicals; the appropriate pyrolysis temperature to produce aldehydes and ketones was 700 °C, and 600 °C was suitable for aromatic compounds. The regularity of the distribution of products and pyrolytic conditions was explored through eight representative compounds. The relationship between the product contents and pyrolysis conditions were complex for Helianthus annuus stems, but partial least squares discriminant analysis (PLS-DA) methods were a powerful tool for screening biochemicals whose absolute contents were sensitive to the pyrolysis conditions.

Enol and Ynol Surrogates: Promising Substrates for Hypervalent Iodine Chemistry

AbstractIn numerous iodine(III)‐mediated methodologies that involve ketone compounds, the enol tautomer is expected to be the reactive species. In this context, the exploration of enol and ynol surrogates as substrates is of great interest. Activated π‐systems have been shown to exhibit interesting and highly exploitable behavior toward hypervalent iodine reagents. This has led to the development of numerous useful oxidative transformations. Enamines, enamides, enol derivatives, haloalkenes, and haloalkynes are all enol or ynol surrogates that are reactive towards the most popular iodanes and iodonium salts. This Focus Review will describe past and on‐going research involving these substrates to gain insight into the similarities and disparities observed in their reactivity profiles.

Transformation and utilization of slowly biodegradable organic matters in biological sewage treatment of anaerobic anoxic oxic systems

This study examined the distribution of carbon sources in two anaerobic anoxic oxic (AAO) sewage treatment plants in Xi’an and investigated the transformation characteristics and utilization potential of slowly biodegradable organic matters (SBOM). Results indicated under anaerobic and aerobic conditions, SBOM could be transformed at a rate of 65% in 8h into more readily biologically utilizable substrates such as volatile fatty acids (VFAs), polysaccharides and proteins. Additionally, non-biodegradable humus-type substances which are difficult to biodegrade and readily accumulate, were also generated. These products could be further hydrolyzed to aldehyde and ketone compounds and then transformed into substances with significant oxygen-containing functional groups and utilized subsequently. The molecular weights of proteinoid substances had a wide distribution and tended to decrease over time. Long hours of microbial reaction increased the proportion of micromolecular substances. This particular increase generated significant bioavailability, which can greatly improve the efficiency of nitrogen removal.

Characterization of a crude oil weathering series by ultrahigh-resolution mass spectrometry using multiple ionization modes

Accidental crude oil releases, such as the Deepwater Horizon (DWH) accident, are always a potential threat to pristine marine ecosystems. Since the toxicity of crude oil heavily depends on its variable composition, the comprehensive characterization of crude oil compounds as a function of weathering is an important area of research. Traditional gas chromatography-based characterization presents significant limitations, and the use of ultrahigh-resolution mass spectrometric (UHRMS) techniques (that allow for the assignment of molecular formulae) has been shown to be better equipped to address the complex nature of crude oils. This study used an Orbitrap Q Exactive mass spectrometer operated at a resolving power of 140,000FWHM with both electrospray ionization (ESI) and atmospheric pressure photoionization (APPI) sources, in order to characterize a crude oil weathering series of the Macondo oil released during the DWH incident (the source oil, two differently weathered surface slicks, and a beached residue). Preliminary gas chromatography mass spectrometry (GC–MS) and gas chromatography flame ionization detection (GC–FID) results suggested that the four oils comprised a true weathering series (including biodegradation and photodegradation in addition to other well-known processes such as dissolution and evaporation). UHRMS results showed a clear increase in oxygenated compounds with weathering, and further suggested a significant gain of acidic compounds, as well as the transformation of phenols to ketonic and quinonic compounds with weathering. A complementary study on a weathered oil sample amended with selected model compounds contributed additional insight into the functional group types that are accessible in each ionization technique.

A 3D Homochiral MOF [Cd2(d-cam)3]•2Hdma•4dma for HPLC Chromatographic Enantioseparation.

Up to now, some chiral metal-organic frameworks (MOFs) have been reported for enantioseparation in liquid chromatography. Here we report a homochiral MOF, [Cd2(d-cam)3]·2Hdma·4dma, used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation. Nine racemates of alcohol, naphthol, ketone, and base compounds were used as analytes for evaluating the separation properties of the chiral MOF packed column. Moreover, some effects such as mobile phase composition, column temperature, and analytes mass for separations on this chiral column also were investigated. The relative standard deviations for the resolution values of run-to-run and column-to-column were less than 2.1% and 3.2%, respectively. The experimental results indicate that the homochiral MOF offered good recognition ability, which promotes the application of chiral MOFs use as stationary phase for enantioseparation.