Keratotic Border Research Articles

Short-term systemic recombinant interferon-γ treatment is ineffective in recalcitrant condylomata acuminata

keratosis, squamous cell carcinoma in situ, basal cell carcinoma, and psoriasis.6 Although psoriasis may be associated with acornoid lamella, in our patient the cornoid lamella was the predominant sign. When cornoid lamellation occurs coincidentally with psoriasis, the characteristic clinical features of porokeratosis are not manifest.6 Thus, in our opinion, this case represents bona fide parokeratosis. It is well established that DSAP may be reproduced by UV irradiation,1and one report documented its induction by PUVA.7 It seems peculiar that this is the first case report of DSAP in a patient with psoriasis who was receiving phototherapy. One reason may be that the incidence of DSAP is so low that there are few patients with coexisting DSAP and psoriasis. Another may be that lesions of DSAP are misdiagnosed as healing psoriasis or as solar keratoses. In our patient's case, the staining of the keratotic border by anthralin prompted us to consider DSAP in the differential diagnosis. Misdiagnosis of DSAP as psoriasis may prompt unnecessarily vigorous phototherapy that may cause a seeming paradoxical increase in the number of lesions and may put the patient at excessive risk for side effects of phototherapy.

Mibelli's porokeratosis of the lips.

Tts clinical appearance and its very elective localization on the border of the lip allow us to distinguish a particular type of Mibelli's porokeratosis (MP). The study of three personal cases and four similar cases found in the literature^1-4permitted us to delineate the clinical, topographic, and morphologic features of MP of the lips. <h3>Report of Cases</h3> The patients ranged in age from 10 to 54 years. In these seven cases, all of the patients were women. The lesion began as a small punctiform keratosis, developed progressively, and attained its final diameter within six to 12 months (5 mm to 2 cm). Morphologically, the lesion essentially consisted of a central area in which the skin was slightly atrophic and depressed, smoother and sometimes keratotic. The essential morphologic feature was the presence at the periphery of a very thin and regular keratotic border forming a filiform line, sometimes 1 mm

Ichthyosis linearis circumflexa Comèl with Trichorrhexis invaginata (Netherton's Syndrom): an ultrastructural study of the skin changes.

An electron microscopical study of skin from 2 patients with ichthyosis linearis circumflexa and trichorrhexis invaginata revealed a severe and localized disturbance of keratinization occuring at the keratotic border of figurate skin lesions. It is characterized by a marked decrease of the desmosome-tonofilament system, lack of membrane coating granules and keratohyalin, and the appearence of roundoval, electron dense bodies in the upper spinous layers. The result is a completely disorganized “stratum corneum”. We consider this unique keratinization disorder to be specific for this disease.