The research was undertaken at Pungu in the Kassena Nankana Municipal Assembly in the Upper East Region of Ghana, in order to assess the adaptation strategies of the impacts of climate change by indigenes with respect to the unpredictable change in climate at the area (Pungu). The study was based on climate change impact on health, water resources, agriculture and socio-economic statuses as questionnaire and interview were the scientific methods utilized in this findings. The results from the assessment showed that, indigenes sleep either outside or inside which is dependent on prevailing atmospheric temperature to prevent heat related illness such as cerebrospinal meningitis (CSM) among others. The study also found out that unpredictable climate change had detrimental impact on water resources and agriculture in the area which inevitably affected their social and economic works. So, adaptation strategies such as hand-dug wells and boreholes are resorted to cope with the impacts of climate change on the aforementioned statuses. Frequent seminars and public education on the awareness of climate change, impacts and adaptation strategies are recommended.