Nowadays the phenomenon of global warming is unequivocal, as confirmed by the latest reports of the IPCC and studies of the climate-change impacts on ecosystems, global economy, and populations. The effect of climate change on groundwater is a very relevant task especially for regions dependent chiefly on groundwater availability, as for the southern Italy. In such a territorial framework, to achieve a detailed hydro-climatological characterization, an Ensemble of 15 RCMs (E15) derived from the EURO-CORDEX project was analyzed considering two IPCC Representative Concentration Pathways (RCP4.5 and RCP8.5). The E15 was calibrated over the period (1950-1996) by a statistical comparison with data observed by the regional meteorological network managed by the former National Hydrological Service (SIMN), Department of Naples. The effects of climate change on air temperature (T), precipitation (P) and, consequently, on actual evapotranspiration (ETR) and effective precipitation Pe (P - ETR) were analyzed until 2100. The latter was considered as a proxy of groundwater recharge of the principal aquifer systems, represented chiefly by the karst aquifers. As a principal result, it was found that the E15 is basically able to reproduce the observed annual precipitation (OBSP) and mean annual air temperature (OBST), being characterized by a very similar frequency distribution. Accordingly, an inferential statistical approach was performed for calibrating E15 precipitation (E15P) and air temperature (E15T) based on the compensation of the difference with OBSP (+ 7%) and OBST (-16%). The E15 projects a reduction in precipitation and an increase in air temperature under both RCPs, with a divergence point between the two scenarios occurring by about 2040. As a principal result, Pe shows declining trends for both RCP scenarios, reaching a decrease of the 11-yrs moving average down to -20%, for RCP4.5, and -50%, for RCP8.5, even if characterized by relevant inter-annual fluctuations.