Nowadays, soil erosion has become the focus of social attention. Due to topography, climate, precipitation, human activities, and other factors, this phenomenon is particularly serious in the Karst landform region. Therefore, this paper takes the classic Karst landform region of Guizhou as an example, dividing the karst landform into two different types, namely, the surface karst landform and the underground karst landform, with different positions as variables. Based on the previous data, systematic analysis of the causes of karst, and factors that promote soil erosion and water runoff in corresponding regions. Looking into the future, the issue of soil erosion in the kalandforms still needs to be changed. For the countermeasures, drainage facilities can optimize runoff, and forestry technology could affect vegetation. However for the long run method for generation after generation, people's awareness should be fundamentally raised. Thus, the most economical way to deal with this is to increase the government and relative department limitations.