Kanagawa Children Research Articles

AbstractWe conducted the study on factors affecsting progonsis of bronchial asthama, clinical course and bronchial sensitivity to acetycholine 127 children with asthma, who received acetylcholine inhalation test and were subjected to observation for at least 3 years in Kanagawa children's Medical Center. First, the children were divided into two groups on the basis of asthmatic attacks. Those without asthamatic attacks for over 2 years were classified into the remission group and those with recent asthamtic episodes, the non‐remission group. A further calssification was based on bronchial sensitivity of acetylcholine. The two groups derived were the hypersensitivity group and the low sensitivity group.The following conclusion were drawn from the long‐term onservation of the patients. 1) One‐rank change in acetylcholine threshold does not correspond to a change in bronchial sensitivity. 2) Imporovement in brochial sensittivity to acetylcholine accompanies the disapperance of asthamtic attacks. 3) Bronchial hypersensitvity to acetylcholine is maintained by the presence of asthmatic attacks. 4) Significant change in brochial sensitivity to acetylcholine does not appear within 2 years of the presence or absence of asthmatic episodes.

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