Following the derivation of a distributed-parameter large basin runoff model from a lumped-parameter version for the Great Lakes in the companion paper, we here apply it to the Kalamazoo River watershed in southwest Michigan. First we review relevant similar efforts and then describe the digitization of the watershed into a network of cells through which watershed internal flows are routed. We present the technology used on the Kalamazoo River to create grids of topography, soils, land use, and vegetation data. We describe the calibration of both lumped-parameter and distributed-parameter runoff models on the Kalamazoo River and use observed spatial data variations in our parameter determinations. We investigate alternative evapotranspiration schemes, spatial parameter patterns, solar insolation interpretations, and temporal scaling and compare model results. We suggest model extensions for future work.