Abstract As the largest submarine fan, the Bay of Bengal (BoB) captures the abundant environment and climate fingerprints on different time scales. To investigate the sedimentary response to climate change since the Last Glacial Maximum (LGM), an integrated survey was performed to study grain size, major, and trace elements (Al2O3, CaO, K2O, Na2O, TiO2, Sr, and Rb) of core BoB-24 sediments from the central BoB. The (K/Al)-TiO2 (%) relationship of the sediments was taken for the discrimination of provenance, which indicated that sediments from core BoB-24 in 24~6.5 cal ka BP were primarily from terrigenous material input from the Himalayas. In contrast, the material contribution from the Indian subcontinent increased distinctly since 6.5 cal ka BP. The rising sea level severed direct material supply, thus causing the evolution of sediment provenance of the central BoB. Meanwhile, the strengthened Indian summer monsoon (ISM) in the Holocene affected detrital material transport from offshore to the central BoB. After understanding the sediment provenance in the study, we choose the sensitive grain-size fraction to show the evolution of hydrodynamic conditions. The chemical index of alteration (CIA) and Ti/Ca and Rb/Sr ratios are calculated to indicate the change in terrigenous input and weathering intensity. The contents of sediment fraction from 11.05 to 15.63 μm, CIA, and ratios of Ti/Ca and Rb/Sr in core BoB-24 showed the same trends, which were low during the last deglaciation and late Holocene but high in the Early Holocene. The trends were strongly correlated with the variation of the Indian summer monsoon, indicating the possible impact of Indian monsoon on sediment transport in the Bay of Bengal. Alternative indicators such as the contents of ratios of Ti/Ca and Rb/Sr, CIA, and sensitive grain-size content in sediments of core BoB-24 jointly record the evolution history of ISM since 24 ka BP in the Bay of Bengal. Although the sensitivity and response of each indicator to the paleoenvironment and paleoclimate change are slightly different, on the whole, the change trend is the same. Specifically, four warm-cold alternating periods (Heinrich Event 1, Bølling/Allerød, Younger Dryas, and Early Holocene Climatic Optimum) had a strong signal in these proxies that indicated that the millennial-scale climate controls the terrigenous input to the Bay of Bengal, where a high value occurs in warm events and low value in cold events. The sedimentary pattern of the northeastern Indian Ocean provides scientific evidence for an insight into the regional response to global climate change and the long-term climate change trend of the human environment across the monsoon region.