K-fold Cross-validation Approach Research Articles

COPDVD: Automated classification of chronic obstructive pulmonary disease on a new collected and evaluated voice dataset

BackgroundChronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. However, the systemic effects of COPD might provide valuable information for early detection. In other words, symptoms caused by systemic effects could be helpful to detect the condition in its early stages. ObjectiveThe proposed study aims to explore whether the voice features extracted from the vowel “a” utterance carry any information that can be predictive of COPD by employing Machine Learning (ML) on a newly collected voice dataset. MethodsForty-eight participants were recruited from the pool of research clinic visitors at Blekinge Institute of Technology (BTH) in Sweden between January 2022 and May 2023. A dataset consisting of 1246 recordings from 48 participants was gathered. The collection of voice recordings containing the vowel “a” utterance commenced following an information and consent meeting with each participant using the VoiceDiagnostic application. The collected voice data was subjected to silence segment removal, feature extraction of baseline acoustic features, and Mel Frequency Cepstrum Coefficients (MFCC). Sociodemographic data was also collected from the participants. Three ML models were investigated for the binary classification of COPD and healthy controls: Random Forest (RF), Support Vector Machine (SVM), and CatBoost (CB). A nested k-fold cross-validation approach was employed. Additionally, the hyperparameters were optimized using grid-search on each ML model. For best performance assessment, accuracy, F1-score, precision, and recall metrics were computed. Afterward, we further examined the best classifier by utilizing the Area Under the Curve (AUC), Average Precision (AP), and SHapley Additive exPlanations (SHAP) feature-importance measures. ResultsThe classifiers RF, SVM, and CB achieved a maximum accuracy of 77 %, 69 %, and 78 % on the test set and 93 %, 78 % and 97 % on the validation set, respectively. The CB classifier outperformed RF and SVM. After further investigation of the best-performing classifier, CB demonstrated the highest performance, producing an AUC of 82 % and AP of 76 %. In addition to age and gender, the mean values of baseline acoustic and MFCC features demonstrate high importance and deterministic characteristics for classification performance in both test and validation sets, though in varied order. ConclusionThis study concludes that the utterance of vowel “a” recordings contain information that can be captured by the CatBoost classifier with high accuracy for the classification of COPD. Additionally, baseline acoustic and MFCC features, in conjunction with age and gender information, can be employed for classification purposes and benefit healthcare for decision support in COPD diagnosis. Clinical trial registration numberNCT05897944.

Optimizing Glioblastoma, IDH-wildtype Treatment Outcomes : A Radiomics and Support Vector Machine -Based Approach to Overall Survival Estimation.

Glioblastoma multiforme (GBM), particularly the IDH-wildtype type, represents a significant clinical challenge due to its aggressive nature and poor prognosis. Despite advancements in medical imaging and its modalities, survival rates have not improved significantly, demanding innovative treatment planning and outcome prediction approaches. This study utilizes a Support Vector Machine (SVM) classifier using radiomics features to predict the overall survival (OS) of GBM, IDH-wildtype patients to short (< 12 Months) and long (>=12 Months) survivors. A dataset comprising multi-parametric MRI (mpMRI) scans from 574 patients was analyzed. Radiomic features were extracted from T1, T2, FLAIR, and T1-Gd sequences. Low variance features were removed, and Recursive Feature Elimination (RFE) was used to select the most informative features. The SVM model was trained using a k-fold cross-validation approach. Furthermore, clinical parameters such as age, gender, and MGMT promoter methylation status were integrated to enhance prediction accuracy. The model showed reasonable results in terms of cross-validated AUC of 0.84 (95% CI: 0.80-0.90) with (p-value < 0.001) effectively categorizing patients into short and long survivors. Log-rank test (Chi-square statistics) analysis for the developed model was 0.00029 along with the 1.20 Cohen's d effect size. Most importantly, clinical data integration further refined the survival estimates, providing a more fitted prediction that considers individual patient characteristics by Kaplan-Meier curve with p-value<0.0001. The proposed method significantly enhances the predictive accuracy of OS outcomes in GBM, IDH-wildtype patients. By integrating detailed imaging features with key clinical indicators, this model offers a robust tool for personalized treatment planning, potentially improving OS.

A comparative study of acoustic and ultrasonic nondestructive testing for evaluating melon quality

Abstract Melon (Cucumis melo L.) is a high-value agricultural commodity known worldwide for its sweet taste and crisp flesh texture, which are important factors for quality and consumer acceptance. Unfortunately, quality testing and determining the optimal harvest time for achieving desired melon characteristics are traditionally performed through destructive methods. The aim of this study was to explore the potential of acoustic and ultrasonic tests for predicting the physicochemical properties of Honey Globe melons (Cucumis melo L. var. inodorus). A total of 100 melon samples were used in this study. For the nondestructive ultrasonic testing, attenuation values served as its variable, whereas in acoustic testing, variables included frequency, magnitude, short-term energy, and zero-moment. Fruit’s flesh firmness and total soluble solids (TSS) as physicochemical quality properties were determined using destructive tests. The calibration phase involved 80 melon samples, employing a K-Fold Cross Validation approach with ten folds, done on Partial Least Square Regression (PLS) modeling. Another 20 melon samples were used for blind testing. Reliability evaluation was done on key metrics, consisting of R2 values, RMSEC (Root Mean Square Error of Calibration), RMSECV (Root Mean Square Error of Cross-Validation), RMSEP (Root Mean Square Error of Prediction), and RPD (Ratio of Performance to Deviation). Analysis results on these metrics collectively support the conclusion that both ultrasonic and acoustic methods exhibit their potential to predict the firmness properties of melon fruits. The best evaluation result that has been conducted for the ultrasonic test uses attenuation, age, and density as predictors to predict fruit firmness, with R2 = 0.763 and RPD = 2.945, while the acoustic test achieved the best result with magnitude used as a predictor to predict fruit firmness with R2 = 0.718 and RPD = 2.230. However, evaluation metrics on the prediction of total soluble solids for both nondestructive tests were still not good enough for application with low R2 and RPD value.

Structural Condition Assessment of Steel Anchorage Using Convolutional Neural Networks and Admittance Response

Structural damage in the steel bridge anchorage, if not diagnosed early, could pose a severe risk of structural collapse. Previous studies have mainly focused on diagnosing prestress loss as a specific type of damage. This study is among the first for the automated identification of multiple types of anchorage damage, including strand damage and bearing plate damage, using deep learning combined with the EMA (electromechanical admittance) technique. The proposed approach employs the 1D CNN (one-dimensional convolutional neural network) algorithm to autonomously learn optimal features from the raw EMA data without complex transformations. The proposed approach is validated using the raw EMA response of a steel bridge anchorage specimen, which contains substantial nonlinearities in damage characteristics. A K-fold cross-validation approach is used to secure a rigorous performance evaluation and generalization across different scenarios. The method demonstrates superior performance compared to established 1D CNN models in assessing multiple damage types in the anchorage specimen, offering a potential alternative paradigm for data-driven damage identification in steel bridge anchorages.

A novel data-driven machine learning techniques to predict compressive strength of fly ash and recycled coarse aggregates based self-compacting concrete

Compressive strength (CS) of concrete is one of the most important factors in the construction industry and various time and effort-consuming tasks are required to measure it. To tackle such problems, the use of machine learning (ML), a branch of artificial intelligence, has recently resulted in a dramatic revolution in the construction sector, resulting in increased efficiency, accuracy, and creativity. Taking these factors into consideration, the current research was conducted on concrete manufactured with recycled coarse aggregate and fly ash generated as a byproduct of construction and demolition activities and thermal power plants. A large dataset consisting of 444 data points, along with ten input parameters, has been collected from the literature to forecast the CS of fly ash and recycled coarse aggregate-based self-compacting concrete. In this regard, ten advanced ML models, including K-Nearest Neighbors (KNN), Extra Tree Regressor (ETR), Bagging Regressor (BR), Adaboost Regressor (AR), Extreme Gradient Boosting (XGB), Linear Regression (LR), Random Forest (RF), Decision Tree Regression (DTR), Support Vector Regression (SVR) and Gradient Boosting Regression (GBR) have been considered. Furthermore, various data visualization plots and model’s performance matrices such as scatter plot, histograms, heatmaps, Shapley Additive Explanation (SHAP) Analysis, Regression Error Characteristics (REC), and errors have been utilized. In order to evaluate the most influential input parameter and depict the overall performance of ML models, sensitivity analysis and Taylor’s diagram are used. As a method of validation, the Kfold cross-validation approach has been implemented to justify the obtained output. Based on the outcome of the study, the BR model has displayed remarkable accuracy with insignificant errors and high R-squared values (R2 = 0.961), while XGB (R2 = 0.959), and DTR (R2 = 0.952) models also achieved commendable, as compared to other ML models. Additionally, water content, curing days, fly ash, and w/c ratio were found to be the most critical components that directly impact the CS of fly ash and RCA-based SCC. To cater to diverse and extensive practices, a graphical user interface has been developed to assist researchers and engineers in getting instant results of their fly ash and RCA-based SCC mixes prior to the execution of time- and resource-consuming laboratory work.

Mathematical Modeling Using ANN Based on k-fold Cross Validation Approach and MOAHA Multi-Objective Optimization Algorithm During Turning of Polyoxymethylene POM-C

Mathematical Modeling Using ANN Based on k-fold Cross Validation Approach and MOAHA Multi-Objective Optimization Algorithm During Turning of Polyoxymethylene POM-C

Effect of social capital, social support and social network formation on the quality of life of American adults during COVID-19

This study aims to evaluate the effect of social capital (SC), social support (SS), and social network formation (SNF) on the quality of life of American adults during COVID-19. Using a probability sample of American adults aged 49+, 2370 respondents were selected from the National Social Life Health and Aging Project (NSHAP) dataset for analysis using an integrated partial least squares based on structural equation modeling (PLS-SEM)-K-fold cross-validation approach. The analysis showed that social capital assessed using civic engagement, social cohesion, socioeconomic status (SES), social support, and social network formation were significantly and positively associated with American adults’ quality of life during the COVID-19 pandemic. Furthermore, the results showed that using the PLS-SEM and K-fold cross-validation approach produced a medium predictive power of the overall model, confirming the importance of SC, SS, and SNF in predicting quality of life-outcomes. These findings suggest that efforts to promote the well-being of American adults, especially older adults, during the pandemic should focus on strengthening social capital, social support and social network formation.

RAGN-L: A stacked ensemble learning technique for classification of Fire-Resistant columns

One of the main challenges in using reinforced concrete materials in structures is to comprehend their fire resistance. The assessment of fire resistance can be performed in a laboratory environment using fire. However, such tests are time-consuming and expensive, and they may not provide a complete assessment of all relevant properties of a particular tested specimen. To that end, the implementation of machine learning (ML) in the investigation of fire-resistant structural performance would be beneficial, as it would also contribute to the reduction of time and cost problems related to traditional techniques. Here, this research proposes a novel ensemble ML approach to classify columns according to their fire resistance characteristics, supporting the application of ML techniques by fire engineers and scientists. The proposed model, named RAGN-L, combines Random Forest, Adaptive Boosting, and Gradient Naive Bayes, and is stacked using the Logistic Regression approach. RAGN-L is evaluated on real-world databases of reinforced concrete columns and concrete-filled steel tube columns, as well as a synthetic database generated by the TVAE deep learning model. The performance of the proposed solution is compared with ten different ML classifiers based on common statistical metrics, accuracy, precision, recall, and f1-score, and validated using the k-fold cross-validation approach. The developed algorithm outperforms ten different classifiers in all databases, with classification accuracies of 86.6%, and 99.6% for the real-world and synthetic databases of reinforced concrete columns, respectively, and 88.1% for the real-world database of concrete-filled steel tube columns.

Hyperspectral imaging benchmark based on machine learning for intraoperative brain tumour detection

Brain surgery is one of the most common and effective treatments for brain tumour. However, neurosurgeons face the challenge of determining the boundaries of the tumour to achieve maximum resection, while avoiding damage to normal tissue that may cause neurological sequelae to patients. Hyperspectral (HS) imaging (HSI) has shown remarkable results as a diagnostic tool for tumour detection in different medical applications. In this work, we demonstrate, with a robust k-fold cross-validation approach, that HSI combined with the proposed processing framework is a promising intraoperative tool for in-vivo identification and delineation of brain tumours, including both primary (high-grade and low-grade) and secondary tumours. Analysis of the in-vivo brain database, consisting of 61 HS images from 34 different patients, achieve a highest median macro F1-Score result of 70.2 ± 7.9% on the test set using both spectral and spatial information. Here, we provide a benchmark based on machine learning for further developments in the field of in-vivo brain tumour detection and delineation using hyperspectral imaging to be used as a real-time decision support tool during neurosurgical workflows.

Automated tuning of denoising algorithms for noise removal in chromatograms

Different algorithms, such as the Savitzky-Golay filter and Whittaker smoother, have been proposed to improve the quality of experimental chromatograms. These approaches avoid excessive noise from hampering data analysis and as such allow an accurate detection and quantification of analytes. These algorithms require fine-tuning of their hyperparameters to regulate their roughness and flexibility. Traditionally, this fine-tuning is done manually until a signal is obtained that removes the noise while conserving valuable peak information. More objective and automated approaches are available, but these are usually method specific and/or require previous knowledge.In this work, the L-and V-curve, k-fold cross-validation, autocorrelation function and residual variance estimation approach are introduced as alternative automated and generally applicable parameter tuning methods. These methods do not require any previous information and are compatible with a multitude of denoising methods. Additionally, for k-fold cross-validation, autocorrelation function and residual variance estimation, a novel implementation based on median estimators is proposed to handle the specific shape of chromatograms, typically composed of alternating flat baselines and sharp peaks. These tuning methods are investigated in combination with four denoising methods; the Savitsky-Golay filter, Whittaker smoother, sparsity assisted signal smoother and baseline estimation and denoising using sparsity approach.It is demonstrated that the median estimators approach significantly improves the denoising and information conservation performance of relevant smoother-tuner combinations up to a factor 4 for simulated datasets and even up to a factor 10 for an experimental chromatogram. Moreover, the parameter tuning methods relying on residual variance estimation, k-fold cross-validation and autocorrelation function lead to similar small root-mean squared errors on the different simulated datasets and experimental chromatograms. The sparsity assisted signal smoother and baseline estimation and denoising using sparsity approach, which both rely on the use of sparsity, systematically outperform the two other methods and are hence most appropriate for chromatograms.

Strength evaluation sustainable concrete with waste ingredients at elevated temperature by employing interpretable algorithms: Optimization and hyper tuning

Mix proportions of the component materials employed significantly affects the concrete's compressive strength (CS) at elevated temperatures. Predicting the CS of concrete under elevated temperatures is complicated and requires the application of reliable and effective algorithms. In the present study, machine learning methods using distinct learners and combined learners, such as bagging and boosting, are used to estimate the CS of concrete at elevated temperatures. This is achieved by the utilization of Anaconda software using Python. The combined learner boosting (Adaboost and Xgboost), bagging, and modified bagging algorithms are utilized in constructing a robust ensemble learner by integrating an individual learner. These ensemble algorithms were incorporated with decision tree (DT), support vector regression (SVR), and multilayer perception neural network (MLPNN) techniques to enhance the robustness of the models. The database used to develop the models comprised 207 data points with nine input parameters: water, temperature, silica fume, cement, fly ash, superplasticizer, sand, Nano silica, and gravels and CS as output. The optimization was performed to achieve the maximum R2 by training the data in 20 sub-models for each boosting and bagging technique. The data is verified by using a K-fold cross-validation approach. In addition, various statistical measures such as MAE, RMSE, NSE, and MSE are employed for cross-validation of the data. Based on the findings, it appears that making use of bagging and boosting learners results in improved particular model performance. In more general terms, RF and DT with bagging produce the most accurate results among the developed models, with a higher R2 value of 0.94 and lesser error values. When it comes to machine learning, having an ensemble model would often improve the model's overall accuracy.

A Novel Methodology for Human Kinematics Motion Detection Based on Smartphones Sensor Data Using Artificial Intelligence

Kinematic motion detection aims to determine a person’s actions based on activity data. Human kinematic motion detection has many valuable applications in health care, such as health monitoring, preventing obesity, virtual reality, daily life monitoring, assisting workers during industry manufacturing, caring for the elderly. Computer vision-based activity recognition is challenging due to problems such as partial occlusion, background clutter, appearance, lighting, viewpoint, and changes in scale. Our research aims to detect human kinematic motions such as walking or running using smartphones’ sensor data within a high-performance framework. An existing dataset based on smartphones’ gyroscope and accelerometer sensor values is utilized for the experiments in our study. Sensor exploratory data analysis was conducted in order to identify valuable patterns and insights from sensor values. The six hyperparameters, tunned artificial indigence-based machine learning, and deep learning techniques were applied for comparison. Extensive experimentation showed that the ensemble learning-based novel ERD (ensemble random forest decision tree) method outperformed other state-of-the-art studies with high-performance accuracy scores. The proposed ERD method combines the random forest and decision tree models, which achieved a 99% classification accuracy score. The proposed method was successfully validated with the k-fold cross-validation approach.

A Comparison of Modeling Methods for Predicting Forest Attributes Using Lidar Metrics

Recent advancements in laser scanning technology have demonstrated great potential for the precise characterization of forests. However, a major challenge in utilizing metrics derived from lidar data for the forest attribute prediction is the high degree of correlation between these metrics, leading to multicollinearity issues when developing multivariate linear regression models. To address this challenge, this study compared the performance of four different modeling methods for predicting various forest attributes using aerial lidar data: (1) Least Squares Regression (LSR), (2) Adaptive Least Absolute Shrinkage and Selection Operator (ALASSO), (3) Random Forest (RF), and (4) Generalized Additive Modeling Selection (GAMSEL). The study used three primary plot-level forest attributes (volume, basal area, and dominant height) as response variables and thirty-nine plot-level lidar metrics as explanatory variables. A k-fold cross-validation approach was used, with consistent folds to assess the performance of each method. Our results revealed that no single method demonstrated a significant advantage over the others. Nonetheless, the highest R2 values of 0.88, 0.83, and 0.87 for volume, basal area, and dominant height, respectively, were achieved using the ALASSO method. This method was also found to be less biased, followed by GAMSEL and LSR.

A Highly Accurate Dysphonia Detection System Using Linear Discriminant Analysis

The recognition of pathological voice is considered a difficult task for speech analysis. Moreover, otolaryngologists needed to rely on oral communication with patients to discover traces of voice pathologies like dysphonia that are caused by voice alteration of vocal folds and their accuracy is between 60%–70%. To enhance detection accuracy and reduce processing speed of dysphonia detection, a novel approach is proposed in this paper. We have leveraged Linear Discriminant Analysis (LDA) to train multiple Machine Learning (ML) models for dysphonia detection. Several ML models are utilized like Support Vector Machine (SVM), Logistic Regression, and K-nearest neighbor (K-NN) to predict the voice pathologies based on features like Mel-Frequency Cepstral Coefficients (MFCC), Fundamental Frequency (F0), Shimmer (%), Jitter (%), and Harmonic to Noise Ratio (HNR). The experiments were performed using Saarbrucken Voice Database (SVD) and a privately collected dataset. The K-fold cross-validation approach was incorporated to increase the robustness and stability of the ML models. According to the experimental results, our proposed approach has a 70% increase in processing speed over Principal Component Analysis (PCA) and performs remarkably well with a recognition accuracy of 95.24% on the SVD dataset surpassing the previous best accuracy of 82.37%. In the case of the private dataset, our proposed method achieved an accuracy rate of 93.37%. It can be an effective non-invasive method to detect dysphonia.

Cryptojacking Malware Detection in Docker Images Using Supervised Machine Learning

Nowadays, Docker Containers are currently being adopted as industry standards for software delivery, because they provide quick and responsive delivery and handle performance and scalability challenges. However, attackers are exploiting them to introduce malicious instructions in publicly available images to perform unauthorized use of third-party’s computer resources for Cryptojacking. We developed a machine learning based model to detect Docker images that lead to cryptojacking. The dataset used is composed of 800 Docker images collected from Docker hub, half of which contains instructions for cryptomining, and the other half does not contain such instructions. We trained 10 classification algorithms and evaluated them using the K-Fold Cross Validation approach. The results showed accuracy scores ranging from 89% to 97%. Stochastic Gradient Descent for Logistic Regression outperformed the other algorithms reaching an accuracy score of 97%. With these results, we conclude that machine learning algorithms can detect Docker images carrying cryptojacking malware with a good performance.

Multi-label classification of Alzheimer's disease stages from resting-state fMRI-based correlation connectivity data and deep learning

Alzheimer's disease is a neurodegenerative condition that gradually impairs cognitive abilities. Recently, various neuroimaging modalities and machine learning methods have surfaced to diagnose Alzheimer's disease. Resting-state fMRI is a neuroimaging modality that has been widely utilized to study brain activity related to neurodegenerative diseases. In literature, the previous studies are limited to the binary classification of Alzheimer's disease and Mild Cognitive Impairment. The application of computer-aided diagnosis for the numerous advancing phases of Alzheimer's disease, on the other hand, remains understudied. This research analyzes and presents methods for multi-label classification of six Alzheimer's stages using rs-fMRI and deep learning. The proposed model solves the multi-class classification problem by extracting the brain's functional connectivity networks from rs-fMRI data and employing two deep learning approaches, Stacked Sparse Autoencoder and Brain Connectivity Graph Convolutional Network. The suggested models' results were assessed using the k-fold cross-validation approach, and an average accuracy of 77.13% and 84.03% was reached for multi-label classification using Stacked Sparse Autoencoders and Brain Connectivity Based Convolutional Network, respectively. An analysis of brain regions was also performed by using the network's learned weights, leading to the conclusion that the precentral gyrus, frontal gyrus, lingual gyrus, and supplementary motor area are the significant brain regions of interest.

Application of Soft-Computing Methods to Evaluate the Compressive Strength of Self-Compacting Concrete.

This research examined machine learning (ML) techniques for predicting the compressive strength (CS) of self-compacting concrete (SCC). Multilayer perceptron (MLP), bagging regressor (BR), and support vector machine (SVM) were utilized for analysis. A total of 169 data points were retrieved from the various published articles. The data set was based on 11 input parameters, such as cement, limestone, fly ash, ground granulated blast-furnace slag, silica fume, rice husk ash, coarse aggregate, fine aggregate, superplasticizers, water, viscosity modifying admixtures, and one output with compressive strength of SCC. In terms of properly predicting the CS of SCC, the BR technique outperformed both the SVM and MLP models, as determined by the research results. In contrast to SVM and MLP, the coefficient of determination (R2) for the BR model was 0.95, whereas for SVM and MLP, the R2 was 0.90 and 0.86, respectively. In addition, a k-fold cross-validation approach was adopted to check the accuracy of the employed models. The statistical measures mean absolute percent error, mean absolute error, and root mean square error ensure the validity of the model. Using sensitivity analysis, the influence of input factors on the intended CS of SCC was also explored. This analysis reveals that the highest contributing parameter towards the CS of SCC was cement with 16.2%, while rice husk ash contributed the least with 4.25% among all the input variables.

Application of data-mining technique and hydro-chemical data for evaluating vulnerability of groundwater in Indo-Gangetic Plain.

Vulnerability of groundwater is critical for the sustainable development of groundwater resources, especially in freshwater-limited coastal Indo-Gangetic plains. Here, we intend to develop an integrated novel approach for delineating groundwater vulnerability using hydro-chemical analysis and data-mining methods, i.e., Decision Tree (DT) and K-Nearest Neighbor (KNN) via k-fold cross-validation (CV) technique. A total of 110 of groundwater samples were obtained during the dry and wet seasons to generate an inventory map. Four K-fold CV approach was used to delineate the vulnerable region from sixteen vulnerability causal factors. The statistical error metrics i.e., receiver operating characteristic-area under the curve (AUC-ROC) and other advanced metrices were adopted to validate model outcomes. The results demonstrated the excellent ability of the proposed models to recognize the vulnerability of groundwater zones in the Indo-Gangetic plain. The DT model revealed higher performance (AUC=0.97) followed by KNN model (AUC=0.95). The north-central and north-eastern parts are more vulnerable due to high salinity, Nitrate (NO3-), Fluoride (F-) and Arsenic (As) concentrations. Policy-makers and groundwater managers can utilize the proposed integrated novel approach and the outcome of groundwater vulnerability maps to attain sustainable groundwater development and safeguard human-induced activities at the regional level.

Quantitative chest computed tomography combined with plasma cytokines predict outcomes in COVID-19 patients

Despite extraordinary international efforts to dampen the spread and understand the mechanisms behind SARS-CoV-2 infections, accessible predictive biomarkers directly applicable in the clinic are yet to be discovered. Recent studies have revealed that diverse types of assays bear limited predictive power for COVID-19 outcomes. Here, we harness the predictive power of chest computed tomography (CT) in combination with plasma cytokines using a machine learning and k-fold cross-validation approach for predicting death during hospitalization and maximum severity degree in COVID-19 patients. Patients (n = 152) from the Mount Sinai Health System in New York with plasma cytokine assessment and a chest CT within five days from admission were included. Demographics, clinical, and laboratory variables, including plasma cytokines (IL-6, IL-8, and TNF-α), were collected from the electronic medical record. We found that CT quantitative alone was better at predicting severity (AUC 0.81) than death (AUC 0.70), while cytokine measurements alone better-predicted death (AUC 0.70) compared to severity (AUC 0.66). When combined, chest CT and plasma cytokines were good predictors of death (AUC 0.78) and maximum severity (AUC 0.82). Finally, we provide a simple scoring system (nomogram) using plasma IL-6, IL-8, TNF-α, ground-glass opacities (GGO) to aerated lung ratio and age as new metrics that may be used to monitor patients upon hospitalization and help physicians make critical decisions and considerations for patients at high risk of death for COVID-19.

Predicting the Rheological Properties of Super-Plasticized Concrete Using Modeling Techniques.

Interface yield stress (YS) and plastic viscosity (PV) have a significant impact on the pumpability of concrete mixes. This study is based on the application of predictive machine learning (PML) techniques to forecast the rheological properties of fresh concrete. The artificial neural network (NN) and random forest (R-F) PML approaches were introduced to anticipate the PV and YS of concrete. In comparison, the R-F model outperforms the NN model by giving the coefficient of determination (R2) values equal to 0.92 and 0.96 for PV and YS, respectively. In contrast, the model’s legitimacy was also verified by applying statistical checks and a k-fold cross validation approach. The mean absolute error, mean square error, and root mean square error values for R-F models by investigating the YS were noted as 30.36 Pa, 1141.76 Pa, and 33.79 Pa, respectively. Similarly, for the PV, these values were noted as 3.52 Pa·s, 16.48 Pa·s, and 4.06 Pa·s, respectively. However, by comparing these values with the NN’s model, they were found to be higher, which also gives confirmation of R-F’s high precision in terms of predicting the outcomes. A validation approach known as k-fold cross validation was also introduced to authenticate the precision of employed models. Moreover, the influence of the input parameters was also investigated with regard to predictions of PV and YS. The proposed study will be beneficial for the researchers and construction industries in terms of saving time, effort, and cost of a project.