Gypsum wallboards are widely used as a building material, but limitations exist in their weight and brittleness. The incorporation of various fillers in the gypsum makes them lightweight, stiff, and capable of resisting catastrophic failure but with the cost of strength. Sandwiching the filled gypsum using a low-cost material as skin may be an innovative approach to improve the flexural properties. In this work, sandwich structures were fabricated using jute fiber reinforced and unreinforced perlite-filled gypsum as cores and low-cost brown paper as skins. The density, flexural strength, modulus, and toughness of the resulting sandwich structures were investigated. It is found that the increase in perlite content in pure gypsum and jute fiber-reinforced gypsum significantly enhances the flexural strength, modulus, and toughness of the sandwich structures. However, previous research on jute fiber-reinforced and unreinforced gypsum/perlite composite panels (without skin) showed a decrease in flexural strength due to an increase in perlite content. The maximum flexural strengths of unreinforced sandwich (URS) and jute fiber reinforced sandwiches (JRS) at a perlite content of 15 g are found to be 13.29 % and 40.79 % greater than the control sandwich with pure gypsum core. The maximum flexural toughness of the JRS at a perlite content of 20 g and that of the URS at a perlite content of 15 g are respectively 118.31 % and 79.14 % greater than the control sandwich. A significant difference in load-displacement curves between JRSs and URSs is noticed despite the similar failure sequence i.e. core cracking→skin yielding→skin tearing.