Deep coal reservoirs, as opposed to their shallower counterparts, exhibit characteristics of higher temperatures and pressures. These conditions affect the fracture structure and mechanical properties of coal, which in turn controls permeability. Substantial studies have been conducted to determine the effects of overburden pressure on permeability, but the correlation between the temperature and mechanical parameters/permeability of coal remains unclear. This study focused on low-rank bituminous coal from the southern edge of the Junggar Basin in Xinjiang. Using experiments conducted on seepage and mechanics at different depths (considering effective stress and temperature), the study investigated how temperature affects the mechanical parameters and permeability of coal column samples. A permeability prediction model was established incorporating temperature, mechanical parameters, and effective stress. The results show that from 20 to 80 °C, the elastic modulus of coal column samples decreases by 31.0%, and the Poisson ratio increases by 72.0%. Permeability decreases between 48.37 and 90.12% under different depths. The stress sensitivity coefficient under various temperature conditions decreased exponentially as the effective stress increased, and the temperature sensitivity coefficient under various effective stress conditions decreased with increasing temperature. The permeability was more sensitive to a temperature below 40 °C. In the permeability prediction model, the fracture compressibility coefficient is bifurcated into two coefficients, each controlled by temperature and effective stress. The permeability prediction error of the model was 12.7% under constant effective stress and 17.2% under varying effective stress and temperature conditions. The study could provide guidance for fracturing and coalbed methane production in deep coal reservoirs.