Junction Resistance Research Articles

Production of Ultrathin and High-Quality Nanosheet Networks via Layer-by-Layer Assembly at Liquid-Liquid Interfaces.

Solution-processable 2D materials are promising candidates for a range of printed electronics applications. Yet maximizing their potential requires solution-phase processing of nanosheets into high-quality networks with carrier mobility (μNet) as close as possible to that of individual nanosheets (μNS). In practice, the presence of internanosheet junctions generally limits electronic conduction, such that the ratio of junction resistance (RJ) to nanosheet resistance (RNS), determines the network mobility via μNS/μNet ≈ RJ/RNS + 1. Hence, achieving RJ/RNS < 1 is a crucial step for implementation of 2D materials in printed electronics applications. In this work, we utilize an advanced liquid-interface deposition process to maximize nanosheet alignment and network uniformity, thus reducing RJ. We demonstrate the approach using graphene and MoS2 as model materials, achieving low RJ/RNS values of 0.5 and 0.2, respectively. The resultant graphene networks show a high conductivity of σNet = 5 × 104 S/m while our semiconducting MoS2 networks demonstrate record mobility of μNet = 30 cm2/(V s), both at extremely low network thickness (tNet < 10 nm). Finally, we show that the deposition process is compatible with nonlayered quasi-2D materials such as silver nanosheets (AgNS), achieving network conductivity close to bulk silver for networks <100 nm-thick.

Aluminum Josephson junction microstructure and electrical properties modified by thermal annealing

Reproducibility of Al/AlOx/Al Josephson junctions is a challenge for scaling up superconducting quantum processors. The frequency uncertainty of the transmon qubits arising from the fabrication process is attributed to deviations in the Josephson junction microstructure and electrical properties. Here, we present a solution for this problem using the post-fabrication Josephson junction thermal annealing process. The developed thermal post-exposure method allows not only to increase the junction resistance by 175%, but also to decrease by 60% with a step of 10% in Rn, which opens up new possibilities for tuning the frequency of qubits. The resistance is shown to be strongly temperature dependent, and is weakly dependent on the holding time. The linear dimensions of the electrodes and the sidewalls contribution to the total JJ area also have a significant impact on the final resistance after annealing. Finally, a theoretical model of the structure modification in a tunnel barrier with changes in oxygen concentration gradient is proposed. The proposed thermal annealing approach can be used to form stable and reproducible tunnel barriers and scalable frequency trimming for widely used fixed-frequency transmon qubits.

Emerging Targets and Treatments for Sarcopenia: A Narrative Review.

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health and quality of life in older adults. This narrative review explores emerging targets and potential treatments for sarcopenia, aiming to provide a comprehensive overview of current and prospective interventions. The review synthesizes current literature on sarcopenia treatment, focusing on recent advancements in muscle regeneration, mitochondrial function, nutritional strategies, and the muscle-microbiome axis. Additionally, pharmacological and lifestyle interventions targeting anabolic resistance and neuromuscular junction integrity are discussed. Resistance training and adequate protein intake remain the cornerstone of sarcopenia management. Emerging strategies include targeting muscle regeneration through myosatellite cell activation, signaling pathways, and chronic inflammation control. Gene editing, stem cell therapy, and microRNA modulation show promise in enhancing muscle repair. Addressing mitochondrial dysfunction through interventions aimed at improving biogenesis, ATP production, and reducing oxidative stress is also highlighted. Nutritional strategies such as leucine supplementation and anti-inflammatory nutrients, along with dietary modifications and probiotics targeting the muscle-microbiome interplay, are discussed as potential treatment options. Hydration and muscle-water balance are emphasized as critical in maintaining muscle health in older adults. A combination of resistance training, nutrition, and emerging therapeutic interventions holds potential to significantly improve muscle function and overall health in the aging population. This review provides a detailed exploration of both established and novel approaches for the prevention and management of sarcopenia, highlighting the need for further research to optimize these strategies.

Inkjet-printed p-type tellurene and n-type MoS2 transistors for CMOS electronics

Abstract Two-dimensional semiconductor materials combine exceptional electronic transport properties with mechanical flexibility and hence can be an ideal choice for large-area flexible and wearable electronics. While inkjet printing may be a suitable approach to fabricate high throughput electronic components on polymer substrates, solution-processed 2D semiconductor network transistors suffer from two major hindrances: extremely high inter-flake resistance and the lack of high-performance p-type semiconductors. This study shows that inkjet-printed tellurium nanowires or tellurene nanoflakes can offer high-performance p-type TFTs with current density up to 100 μA/μm and an On-Off ratio &gt;105. In order to circumvent the high inter-flake junction resistance, a narrow-channel, near-vertical device architecture has been used that ensures predominantly intra-flake/ intra-nanowire transport, which resulted in three orders of magnitude increase in the current density compared to conventional devices without compromising on the On-Off ratio. Moreover, we show the whole device operation within ± 2 V, with a threshold voltage close to 0 V. The complete device fabrication is carried out at room temperature, thereby making it compatible with inexpensive polymer substrates. Next, outstanding device performance has also been realized with electrochemically-exfoliated and inkjet-printed n-type MoS2 TFTs, demonstrating a current density of 60 μA/μm and an On-Off ratio of 106. Furthermore, we show tellurene-based p-type depletion-load unipolar inverters and CMOS inverters alongside n-type MoS2 TFTs, demonstrating a signal gain of 12 and 11, respectively. The CMOS inverters are found to operate at a frequency of 1 kHz.&amp;#xD;

Impedance Spectroscopy Study of Charge Transfer in the Bulk and Across the Interface in Networked SnO2/Ga2O3 Core–Shell Nanobelts in Ambient Air

Metal oxide core–shell fibrous nanostructures are promising gas-sensitive materials for the detection of a wide variety of both reducing and oxidizing gases. In these structures, two dissimilar materials with different work functions are brought into contact to form a coaxial heterojunction. The influence of the shell material on the transportation of the electric charge carriers along these structures is still not very well understood. This is due to homo-, hetero- and metal/semiconductor junctions, which make it difficult to investigate the electric charge transfer using direct current methods. However, in order to improve the gas-sensing properties of these complex structures, it is necessary to first establish a good understanding of the electric charge transfer in ambient air. In this article, we present an impedance spectroscopy study of networked SnO2/Ga2O3 core–shell nanobelts in ambient air. Tin dioxide nanobelts were grown directly on interdigitated gold electrodes, using the thermal sublimation method, via the vapor–liquid–solid (VLS) mechanism. Two forms of a gallium oxide shell of varying thickness were prepared via halide vapor-phase epitaxy (HVPE), and the impedance spectra were measured at 189–768 °C. The bulk resistance of the core–shell nanobelts was found to be reduced due to the formation of an electron accumulation layer in the SnO2 core. At temperatures above 530 °C, the thermal reduction of SnO2 and the associated decrease in its work function caused electrons to flow from the accumulation layer into the Ga2O3 shell, which resulted in an increase in bulk resistance. The junction resistance of said core–shell nanostructures was comparable to that of SnO2 nanobelts, as both structures are likely connected through existing SnO2/SnO2 homojunctions comprising thin amorphous layers.

Investigation on Junction Contacts of Semiconducting Carbon Nanotube Networks Using Conductive Atomic Force Microscopy.

Semiconductor single-walled carbon nanotube (s-SWNT) networks have gained prominence in electronic devices due to their cost-effectiveness, relatively production-naturality, and satisfactory performance. Configuration, density, and resistance of SWNT-SWNT junctions are considered crucial factors influencing the overall conductivity of s-SWNT networks. In this study, we present a method for inferring the lower bounds of the SWNT-SWNT junction resistance in s-SWNT networks based on conductive atomic force microscopy TUNA images. This method further enables the proposal of a classification for SWNT-SWNT junctions based on the current behavior relative to their surroundings. The three types of SWNT-SWNT junctions are denoted as (i) true contact (T), (ii) poor contact (P), and (iii) false contact (F). Of them, the true and poor contacts, respectively, represent good and poor electrical contact for the subject SWNT-SWNT junctions whose electrical conductivity hardly improves under external tip pressure, while that of the false contact can be further improved by external pressure. Statistical analysis demonstrates that while T-type junctions make a significant contribution to network conductivity, their proportion accounts for only approximately 40%. The P-type and F-type junctions, which constitute over 60% of the total, may be a contributing factor that constrains the overall conductivity of the s-SWNT networks. The height ratio of the junction to the sum of two SWNTs was also observed to exhibit variations among the three types. Finally, we propose a three-dimensional model to elucidate the formation mechanism underlying each type of junction. The present study provides insights into the performance of spontaneous contacts between s-SWNTs in the networks, and the systematic image acquisition and junction classification processes may provide support for future advancements in these networks.

Simulation study of cadmium-free CIGS solar cell for efficiency enhancement by minimizing recombination losses through back surface field mechanism

Thin-film photovoltaic cells provide benefits over conventional first-generation technology, including lighter weight, greater flexibility, and lower power generation costs. Chalcogenide solar cells offer good efficiency and technological maturity among thin-film technology. In this work, a solar cell device structure, Al/FTO/SnS2/CIGS/CuO/Ni, is examined using SCAPS-1D. Further, by incorporating the back surface field (BSF) layer, the conversion efficiency increased from 18.93 % to 29.88 %, followed by VOC of 0.96 V, JSC of 37.07 mA cm−2, and FF of 83.71 %. This increment in device performance is owing to the lowering back surface recombination velocity and the additional hole tunnelling activity offered by the BSF layer by forming a quasi-ohmic contact, i.e. metal-semiconductor contact with negligible junction resistance relative to the total resistance of the device. Throughout this research work, the authors studied several factors such as surface recombination velocity, temperature impact, front and back contact metal work functions, parasitic resistance impact, gallium proportion, and doping density impact on CIGS solar cells. The work also included a calibration with experimental data from published sources to validate the simulation results.This paper presents a new approach for producing high-efficiency, eco-friendly CIGS solar cells with CuO back surface field mechanism.

In situ Non-destructive Measurement of Josephson Junction Resistance Using Fritting Contact Technique

Abstract Conventional four-probe methods for measuring the resistance of Josephson junctions can damage superconducting thin films, making them unsuitable for frequency measurements of superconducting qubits. In this study, we present a custom probe station measurement system that employs the fritting contact technique to achieve in situ, non-destructive measurements of Josephson junction resistance. Our experimental results demonstrate that this method allows for accurate prediction of qubit frequency with an error margin of 17.2 MHz. Moreover, the fritting contact technique does not significantly affect qubit coherence time or the integrity of the superconducting film, confirming its non-destructive nature. This innovative approach provides a dependable foundation for frequency tuning and addressing frequency collision issues, thus supporting the advancement and practical deployment of superconducting quantum computing.

Giant tunneling resistance and robust switching behavior in ferroelectric tunnel junctions of WS2/Ga2O3 heterostructures: The influence of metal–semiconductor contacts

The ferroelectric tunneling junctions (FTJs) are widely recognized as one of the non-volatile memories with significant potential. Ferroelectricity usually fades away as materials are thinned down below a critical value, and this problem is particularly acute in the case of shrinking device sizes, thus attracting attention to two-dimensional ferroelectric materials (2DFEMs). In this work, we designed 2D ferroelectric Ga2O3-based FTJs with out-of-plane polarization, and the influence of metal–semiconductor contact in the electrode region on the system is considered. Here, using density functional theory combined with the non-equilibrium Green's function approach to quantum transport calculations, we demonstrate robust ferroelectric polarization-controlled switching behavior between metallic and semiconducting states in Ga2O3/WS2 ferroelectric heterostructures. The potential barrier of the metal–semiconductor contact in the electrode region is lower than that of the intrinsic material, thereby resulting in an increased probability of electron tunneling. Our results reveal the crucial role of 2DFEMs in the construction of FTJs and highlight the significant impact of electrode contact types on performance. This provides a promising approach for developing high-density ferroelectric memories based on 2D ferroelectric semiconductor heterostructures.

Flexible thin-film thermoelectric generators for human skin-heat harvesting: A numerical study

By harvesting thermal energy from human skin, self-powered wearable electronics have the potential to overcome the limitations of battery power, enabling long-term continuous operation. Flexible thermoelectric generators (TEGs) that can form a conformal contact with heat sources of any shape are critical for self-powered wearables. Nevertheless, practical implementations and efficient harvesting of heat energy from the human body are still hindered by factors that significantly diminish the power output of flexible TEGs. In this work, we present a design framework and computational platform optimized for modelling the harvesting of skin-heat energy using organic-based flexible thin-film TEGs. First, a three-dimensional numerical model based on the finite element method (FEM) has been developed, which enables the study and optimization of organic-based film thermoelectric (TE) device and TEG parameters, such as width, length, thickness, and interconnection dimensions, to maximize performance. Then, the optimized flexible TEG has been used to investigate the effect of human skin on wearable device applications in different parts of the body and environmental conditions. Mechanical interlayers designed to control various interface functions can alter junction resistances, leading to structures that are either highly conductive or insulating. Soft heat conductor (SHC) and soft heat insulator (SHI) layers are embedded to enhance the thermal interfaces and temperature difference across the TEG. As a result, embedding these soft heat layers can increase the temperature difference (ΔT) and open circuit voltage (VOC) along the TEG by ∼30 % over conventional flexible thin-film TEGs, while preserving mechanical softness and flexibility. Additionally, a study on the impact of the skin/TEG matching and heat flux at the skin/TEG interface is presented. Lastly, using a state-of-the-art post-treated poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) film-based TEG device model, we determined the maximum power output obtainable on various parts of the human body under three distinct environmental conditions (cold, room, and hot temperatures).

Diagnosis and management of sarcopenia

Background: Sarcopenia refers to the progressive and generalized loss of skeletal muscle mass, strength, and function and is associated with falls, fractures, hospitalization, and even mortality. Owing to rapid population aging, the prevalence of sarcopenia is expected to increase, and this condition is increasingly gaining attention as an important topic in research and clinical settings. This review focuses on the diagnosis, pathophysiology, and management of sarcopenia.Current Concepts: Diagnosis of sarcopenia can be confirmed based on low muscle mass accompanied by low muscle strength, or low physical performance. The European Working Group on Sarcopenia in Older People and the Asian Working Group for Sarcopenia guidelines are commonly used in clinical practice. Intrinsic factors associated with skeletal muscles, such as inflammation, anabolic resistance, mitochondria, and neuromuscular junctions, combined with extrinsic factors associated with the systemic environment, including decreased endocrine function, malnutrition, and immobilization all play a role in impaired muscle anabolism, muscle atrophy, and weakness. Currently, the Food and Drug Administration has not approved any specific medications for treatment of sarcopenia. Therefore, non-pharmacological interventions such as aerobic, resistance, and combined exercise and appropriate nutrition (protein and essential amino acids) are important for prevention and treatment of sarcopenia.Discussion and Conclusion: Sarcopenia is a manageable target for improvement of overall health outcomes. Exercise and nutrition are essential components of nonpharmacological management of sarcopenia. Future studies are needed to identify early diagnostic biomarkers and pharmacologic targets and to develop consistent pre-emptive management strategies and sensitive measures to predict effectiveness of sarcopenia management and treatment response.

Cell-Electrode Models for Impedance Analysis of Epithelial and Endothelial Monolayers Cultured on Microelectrodes.

Electric cell-substrate impedance sensing has been used to measure transepithelial and transendothelial impedances of cultured cell layers and extract cell parameters such as junctional resistance, cell-substrate separation, and membrane capacitance. Previously, a three-path cell-electrode model comprising two transcellular pathways and one paracellular pathway was developed for the impedance analysis of MDCK cells. By ignoring the resistances of the lateral intercellular spaces, we develop a simplified three-path model for the impedance analysis of epithelial cells and solve the model equations in a closed form. The calculated impedance values obtained from this simplified cell-electrode model at frequencies ranging from 31.25 Hz to 100 kHz agree well with the experimental data obtained from MDCK and OVCA429 cells. We also describe how the change in each model-fitting parameter influences the electrical impedance spectra of MDCK cell layers. By assuming that the junctional resistance is much smaller than the specific impedance through the lateral cell membrane, the simplified three-path model reduces to a two-path model, which can be used for the impedance analysis of endothelial cells and other disk-shaped cells with low junctional resistances. The measured impedance spectra of HUVEC and HaCaT cell monolayers nearly coincide with the impedance data calculated from the two-path model.

Understanding how junction resistances impact the conduction mechanism in nano-networks

Networks of nanowires, nanotubes, and nanosheets are important for many applications in printed electronics. However, the network conductivity and mobility are usually limited by the resistance between the particles, often referred to as the junction resistance. Minimising the junction resistance has proven to be challenging, partly because it is difficult to measure. Here, we develop a simple model for electrical conduction in networks of 1D or 2D nanomaterials that allows us to extract junction and nanoparticle resistances from particle-size-dependent DC network resistivity data. We find junction resistances in porous networks to scale with nanoparticle resistivity and vary from 5 Ω for silver nanosheets to 24 GΩ for WS2 nanosheets. Moreover, our model allows junction and nanoparticle resistances to be obtained simultaneously from AC impedance spectra of semiconducting nanosheet networks. Through our model, we use the impedance data to directly link the high mobility of aligned networks of electrochemically exfoliated MoS2 nanosheets (≈ 7 cm2 V−1 s−1) to low junction resistances of ∼2.3 MΩ. Temperature-dependent impedance measurements also allow us to comprehensively investigate transport mechanisms within the network and quantitatively differentiate intra-nanosheet phonon-limited bandlike transport from inter-nanosheet hopping.

Chemically doped, purified bulk multi-walled carbon nanotube conductors with enhanced AC conductivity to 40 GHz

Metals used in radio frequency (RF) communications technologies degrade in alternating current (AC) conductivity with frequency due to the skin effect. Bulk carbon nanotube (CNT) materials have demonstrated favorable trends such as constant or increasing AC conductivity, and are emerging as potential alternative conductors. However, the resistive inter-CNT junctions present in these bulk assemblies limit overall conductivity. In this work, a waveguide-based transmission technique is used to measure the AC conductivity from 10 to 40 GHz of a commercial multi-walled CNT (MWCNT) material modified by purification to remove carbon and iron impurities, and by chemical doping with potassium tetrabromoaurate (KAuBr4). Iron impurity removal yields a frequency-independent real AC conductivity. Laser thinning and solvent plying are employed to change transmission by altering the MWCNT sheet thickness, thus enabling accurate measurement of the KAuBr4-doped MWCNT samples. Doping of the purified MWCNTs yields enhanced real AC conductivity of ∼160 kS/m, which remains constant with frequency to 40 GHz and represents a 5–6 × improvement over the as-received material at 40 GHz. KAuBr4 doping is hypothesized to enhance AC conductivity by increasing carrier density, supported by the elevated plasma frequency determined from fitting of a generalized Drude conduction model to the AC conductivity data.

Bergapten enhances mitophagy to regulate intestinal barrier and Th17/Treg balance in mice with Crohn's disease-like colitis via PPARγ/NF-κB signaling pathway.

This study aimed to investigate whether bergapten (BG), a furanocoumarin phytohormone, holds promise for Crohn's disease (CD)-like colitis treatment and to preliminarily explore its potential mechanisms. 2,4,6-Trinitrobenzenesufonic acid (TNBS)-treated mice were applied to establish an in vivo research model, and BG was administered with different concentrations. The status of mice in each group was evaluated by disease activity index (DAI), and the severity was evaluated by pathological sections. The intestinal barrier was assessed by measuring in vivo intestinal permeability, peripheral blood intestinal fatty acid-binding protein (I-FABP) levels, epithelial resistance values, and tight junction protein levels. Markers were then used to assess Th17/Treg levels, mitophagy, and the peroxisome proliferator-activated receptor (PPAR)γ/ nuclear factor kappa B (NF-κB) signaling pathway. BG significantly reduced colon tissue damage in a concentration-dependent manner. DAI scores showed that the loose feces, occult blood, and weight loss of mice in the BG treatment were significantly reduced, and pathological section results revealed reduced inflammatory infiltration and fibrosis. Reduced serum FITC-dextran and I-FABP and increased levels of epithelial resistance and tight junction proteins support that the intestinal barrier was protected upon BG. The proportion of Th17 in mesenteric lymph nodes increased while Treg decreased in the model group. BG treatment effectively reduced the conversion of Treg to Th17. Additionally, BG was found to enhance mitophagy and activate the PPARγ/NF-κB signaling. BG demonstrates promising effects in ameliorating intestinal barrier damage and Th17/Treg imbalance in a murine model of CD-like colitis, while also promoting intracellular mitophagy. The PPARγ/NF-κB signaling pathway may serve as a key mediator of BG's regulatory mechanisms.

Current dependence of the low bias resistance of small capacitance Josephson junctions

The dc current-voltage characteristics of small Josephson junctions reveal features that are not observed in larger junctions, in particular, a switch to the finite voltage state at current values much less than the expected critical current of the junction and a finite resistance in the nominally superconducting regime. Both phenomena are due to the increased sensitivity to noise associated with the small capacitance of the Josephson junction and have been extensively studied a few decades ago. Here I focus on the current bias dependence of the differential resistance of the junction at low current bias in the nominally superconducting regime, using a quantum Langevin equation approach that enables a physically transparent incorporation of the noise environment of the junction. A similar approach might be useful in modeling the sensitivity of superconducting qubits to noise in the microwave regime.

High-Performance Airflow Sensors Based on Suspended Ultralong Carbon Nanotube Crossed Networks.

Airflow sensors are in huge demand in many fields such as the aerospace industry, weather forecasting, environmental monitoring, chemical and biological engineering, health monitoring, wearable smart devices, etc. However, traditional airflow sensors can hardly meet the requirements of these applications in the aspects of sensitivity, response speed, detection threshold, detection range, and power consumption. Herein, this work reports high-performance airflow sensors based on suspended ultralong carbon nanotube (CNT) crossed networks (SCNT-CNs). The unique topologies of SCNT-CNs with abundant X junctions can fully exhibit the extraordinary intrinsic properties of ultralong CNTs and significantly improve the sensing performance and robustness of SCNT-CNs-based airflow sensors, which simultaneously achieved high sensitivity, fast response speed, low detection threshold, and wide detection range. Moreover, the capability for encapsulation also guaranteed the practicality of SCNT-CNs, enabling their applications in respiratory monitoring, flow rate display and transient response analysis. Simulations were used to unveil the sensing mechanisms of SCNT-CNs, showing that the piezoresistive responses were mainly attributed to the variation of junction resistances. This work shows that SCNT-CNs have many superiorities in the fabrication of advanced airflow sensors as well as other related applications.

P‐1.6: Junction Resistance and Junction Diffusion Depth in InGaZnO‐based Thin Film Transistors (TFTs) with Thermally induced Source/Drain Region

P‐1.6: Junction Resistance and Junction Diffusion Depth in InGaZnO‐based Thin Film Transistors (TFTs) with Thermally induced Source/Drain Region

Anti-Inflammatory Effects of a Novel Acetonitrile-Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 Cells.

Natural compounds like flavonoids preserve intestinal mucosal integrity through their antioxidant, anti-inflammatory, and antimicrobial properties. Additionally, some flavonoids show prebiotic abilities, promoting the growth and activity of beneficial gut bacteria. This study investigates the protective impact of Lens culinaris extract (LE), which is abundant in flavonoids, on intestinal mucosal integrity during LPS-induced inflammation. Using Caco-2 cells as a model for the intestinal barrier, the study found that LE did not affect cell viability but played a cytoprotective role in the presence of LPS. LE improved transepithelial electrical resistance (TEER) and tight junction (TJ) protein levels, which are crucial for barrier integrity. It also countered the upregulation of pro-inflammatory genes TRPA1 and TRPV1 induced by LPS and reduced pro-inflammatory markers like TNF-α, NF-κB, IL-1β, and IL-8. Moreover, LE reversed the LPS-induced upregulation of AQP8 and TLR-4 expression. These findings emphasize the potential of natural compounds like LE to regulate the intestinal barrier and reduce inflammation's harmful effects on intestinal cells. More research is required to understand their mechanisms and explore therapeutic applications, especially for gastrointestinal inflammatory conditions.

5-HT1F receptor agonism induces mitochondrial biogenesis and increases cellular function in brain microvascular endothelial cells.

Vascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT1FR) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS. Lasmiditan is a selective 5-HT1FR agonist that is FDA-approved for the treatment of migraines. We have recently shown that lasmiditan treatment induces MB, promotes vascular recovery and improves locomotor function in a mouse model of spinal cord injury (SCI). To investigate the mechanism of this effect, primary cerebral microvascular endothelial cells from C57bl/6 mice (mBMEC) were used. Lasmiditan treatment increased the maximal oxygen consumption rate, mitochondrial proteins and mitochondrial density in mBMEC, indicative of MB induction. Lasmiditan also enhanced endothelial cell migration and tube formation, key components of angiogenesis. Trans-endothelial electrical resistance (TEER) and tight junction protein expression, including claudin-5, were also increased with lasmiditan, suggesting improved barrier function. Finally, lasmiditan treatment decreased phosphorylated VE-Cadherin and induced activation of the Akt-FoxO1 pathway, which decreases FoxO1-mediated inhibition of claudin-5 transcription. These data demonstrate that lasmiditan induces MB and enhances endothelial cell function, likely via the VE-Cadherin-Akt-FoxO1-claudin-5 signaling axis. Given the importance of mitochondrial and vascular dysfunction in neuropathologies, 5-HT1FR agonism may have broad therapeutic potential to address multiple facets of disease progression by promoting MB and vascular recovery.