Junction Barrier Research Articles

Photoelectrochemical performance of spray-deposited Fe-doped ZnS0.2Se0.8 thin films

Binary and ternary II–VI group semiconductor compounds are materials with potential use in various optoelectronic applications, including photoelectrochemical (PEC) solar cells. Thin films of ZnS0.2Se0.8 with various Fe-doping concentrations were successfully deposited on fluorine-doped tin oxide-coated glass substrates at a deposition temperature of 275 °C using the chemical spray pyrolysis. PEC cells with Fe:ZnS0.2Se0.8 thin film/1 M polysulphide/C (graphite) configurations were designed, and the effect of Fe doping on the PEC performance was studied. The results showed that Fe doping in ZnS0.2Se0.8 enhanced the performance of the PEC cells significantly. The optimum concentration was 0.20 mol%. The flat band potential and junction barrier height were maximum at this concentration, with values of −1.18 V and 0.27 eV, respectively. The junction ideality factors of the 0.20 mol% Fe-doped ZnS0.2Se0.8 thin film-based PEC cell in the dark and under illumination were found to be 1.21 and 1.17, respectively. The photovoltaic power output characteristics were boosted by Fe doping with a concentration of 0.20 mol%, with the open circuit voltage being 320 mV and the short circuit current being 1.48 mA cm−2. The solar-to-electrical conversion and the fill factor of the 0.20 mol% Fe-doped ZnS0.2Se0.8 thin film-based PEC cells were superior, with values of 2.84% and 0.60, respectively. A PEC cell with a 0.20 mol% Fe-doped ZnS0.2Se0.8 photosensitive thin film had the highest spectral sensitivity, at a wavelength of 375 nm, with an optical band gap of 3.30 eV.

Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1–Deficient Mice

Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine glands of mammals, exhibit a form of polarized stratified epithelium equipped with tight junctions (TJs), and found that holocrine secretion occurred outside the TJ barriers. Sebaceous glands share characteristics of stratified epithelia with interfollicular epidermis, including basal-layer-restricted cell proliferation, TJ barrier formation at a specific single layer of cells with apico-basolateral plasma membrane polarity, and cell death outside the TJ barrier. Knockout of claudin-1, a transmembrane adhesive protein in TJs, in mice caused leakage of the TJ barrier in sebaceous glands and incomplete degradation of the plasma membrane and nuclei during holocrine secretion. Claudin-1 knockout resulted in the accumulation of incompletely degenerated sebocytes in sebaceous ducts, suggesting that the TJ barrier was necessary for differentiation of holocrine secretion. The redefinition of sebaceous glands as TJ-forming stratified epithelia provides an important framework to understand the molecular mechanism of holocrine secretion.

Phosphatidylcholine Passes by Paracellular Transport to the Apical Side of the Polarized Biliary Tumor Cell Line Mz-ChA-1

Phosphatidylcholine (PC) translocation into mucus of the intestine was shown to occur via a paracellular transport across the apical/lateral tight junction (TJ) barrier. In case this could also be operative in biliary epithelial cells, this may have implication for the pathogenesis of primary sclerosing cholangitis (PSC). We here evaluated the transport of PC across polarized cholangiocytes. Therefore, the biliary tumor cell line Mz-ChA-1 was grown to confluency. In transwell culture systems the translocation of PC to the apical compartment was analyzed. After 21 days in culture, polarized Mz-ChA-1 cells revealed a predominant apical translocation of choline containing phospholipids including PC with minimal intracellular accumulation. Transport was suppressed by TJ destruction employing chemical inhibitors and pretreatment with siRNA to TJ forming proteins as well as the apical transmembrane mucin 3 as PC acceptor. Apical translocation was dependent on a negative apical electrical potential created by the cystic fibrosis transmembrane conductance regulator (CFTR) and the anion exchange protein 2 (AE2). It was stimulated by apical application of secretory mucins. The results indicated the existence of a paracellular PC passage across apical/lateral TJ of the polarized biliary epithelial tumor cell line Mz-ChA-1. This has implication for the generation of a protective mucus barrier in the biliary tree.

Lucifer Yellow - A Robust Paracellular Permeability Marker in a Cell Model of the Human Blood-brain Barrier.

The blood-brain barrier BBB consists of endothelial cells that form a barrier between the systemic circulation and the brain to prevent the exchange of non-essential ions and toxic substances. Tight junctions (TJ) effectively seal the paracellular space in the monolayers resulting in an intact barrier. This study describes a LY-based fluorescence assay that can be used to determine its apparent permeability coefficient (Papp) and in turn can be used to determine the kinetics of the formation of confluent monolayers and the resulting tight junction barrier integrity in hCMEC/D3 monolayers. We further demonstrate an additional utility of this assay to determine TJ functional integrity in transfected cells. Our data from the LY Papp assay shows that the hCMEC/D3 cells seeded in a transwell setup effectively limit LY paracellular transport 7 days-post culture. As an additional utility of the presented assay, we also demonstrate that the DNA nanoparticle transfection does not alter LY paracellular transport in hCMEC/D3 monolayers.

Degradation in electrothermal characteristics of 4H-SiC junction barrier Schottky diodes under high temperature power cycling stress

The electrothermal characteristics and degradation mechanism of 4H-SiC JBS under high temperature power cycling (HTPC) stress were investigated based on thermal structure function, failure analysis and electrothermal simulation. Results show that, the HTPC stress at different temperature conditions (maximum junction temperature Tjmax = 150 °C and Tjmax = 200 °C) have different effects on the reverse breakdown voltage (Vbr), reverse leakage current and the on-resistance (Ron-sp). It was that the increased reverse leakage currents with HTPC stress are due to the Schottky barrier lowering at the beginning. However, as the heat concentration effect increased at the metal/4H-SiC interface, the contribution of tunneling to leakage current is the major components. So the heat flux path and thermal distribution are very crucial to the reliability of chip and package. It can be concluded that the degradations of die-attach, die surface and metal/SiC interface are the main reliability limiting factors of SiC JBS diodes under high temperature applications.

Stacked Josephson Junctions as Inductors for Single Flux Quantum Circuits

Large-scale integration of single flux quantum (SFQ) circuits requires components as compact as possible. In this paper, we study the feasibility of integrating vertically stacked Josephson inductors (VSJIs) fabricated with self-shunted Josephson junctions into our SFQ-based circuits, and use both dc and RF electrical measurements to verify the performance of these junction stacks as compact inductors. The VSJIs consist of three Josephson junctions stacked vertically and are inserted into test structures to validate their potential as compact alternatives to geometrical inductors. The VSJIs are designed to be non-switching junctions and are combined with smaller area, switching Josephson junctions fabricated with the same junction barrier process. The VSJIs have a designed critical current of approximately 50% greater than that of the switching junctions, and their observed behavior can be modeled correctly by including the known nonlinearity of the Josephson inductance. To confirm that this nonlinearity does not degrade the expected bias margins, we simulate two common types of SFQ cells with the geometrical inductors replaced by VSJIs. The results verify that incorporating VSJIs in SFQ circuits would increase circuit density with minimal impact on circuit margins.

Brazilian propolis extract reduces intestinal barrier defects and inflammation in a colitic mouse model

Brazilian propolis is rich in cinnamic acid derivatives and reportedly reduces intestinal inflammation in rodents; however, the underlying mechanisms remain unclear. We hypothesized that the regulation of tight junction (TJ) barrier, Th17 cell differentiation, and/or, macrophage activation by cinnamic acid derivatives were involved in the propolis-mediated anti-inflammatory effect. Mice were orally administered 2% dextran sodium sulfate (DSS) in combination with either the feeding control or a diet containing 0.3% ethanol extract of Brazilian propolis for 9 days. DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL-17a. Cinnamic acid derivatives, such as artepillin C and caffeic acid phenethyl ester, present in the propolis extract suppressed the IL-17 production from cultured murine splenocytes through decreased retinoic acid-related orphan receptor gT expression. Baccharin, drupanin, and culifolin, which are also present in Brazilian propolis, reduced the TNF-α and/or IL-6 production by suppressing inflammatory signaling in murine RAW 264.7 macrophages. Taken together, the regulation of Th17 differentiation and macrophage activation by cinnamic acid derivatives, at least in part, contribute to the anti-inflammatory effect mediated by Brazilian propolis.

Internalin AB-expressing recombinant Lactobacillus casei protects Caco-2 cells from Listeria monocytogenes-induced damages under simulated intestinal conditions.

BackgroundListeria monocytogenes is an intracellular foodborne pathogen that employs a number of strategies to survive challenging gastrointestinal conditions. It proliferates in the gut and subsequently causes listeriosis in high-risk individuals. Therefore, inhibition of its adherence to the intestinal receptors is crucial in controlling its infection. In this study, the effect of our previously developed recombinant Lactobacillus casei strain expressing invasion protein, Internalin AB of L. monocytogenes (LbcInlAB) on epithelial infection processes of the latter under simulated intestinal conditions was investigated.Materials and methodsThe confluent Caco-2 cell monolayer was pre-exposed to different L. casei strains at a multiplicity of exposure (MOE) of 10 for various periods before infection with L. monocytogenes at a multiplicity of infection (MOI) of 10 under simulated intestinal conditions. Subsequently, L. monocytogenes adhesion, invasion, and translocation, cytotoxicity and impact on tight junction integrity of the Caco-2 cells were analyzed.ResultsUnder the simulated gastrointestinal condition, LbcInlAB showed a significant increase (p<0.0001) in adherence to, invasion and translocation through the Caco-2 cells when compared with the wild type strain. Although LbcInlAB strain exhibited enhanced inhibition of L. monocytogenes, it was not able to displace L. monocytogenes cells already attached to the monolayer. Additionally, pre-exposure to LbcInlAB reduced L. monocytogenes-mediated cytotoxicity and protected the tight junction barrier function.ConclusionThe recombinant L. casei expressing InlAB shows potential for use as a prophylactic intervention strategy for targeted control of L. monocytogenes during the intestinal phase of infection.

Radiation Defects Created in n‐Type 4H‐SiC by Electron Irradiation in the Energy Range of 1–10 MeV

Radiation damage produced in 4H‐SiC n‐epilayers by electrons of different energies is presented. Junction barrier Schottky power SiC diodes are irradiated with 1.05, 2.1, 5, and 10 MeV electrons with doses up to 600 kGy. Radiation defects are characterized by capacitance deep‐level transient spectroscopy and capacitance‐to‐voltage (C–V) measurement. Results, which are compared with previous data obtained on 4.5 MeV electrons, show that the damage structure is very similar for all irradiation energies. Dominating is the generation of simple, thermally unstable defects evidenced by the presence of acceptor levels located at 0.25, 0.38, 0.60, and 0.72 eV below the 4H‐SiC conduction band edge. With increasing energy of electrons, the number of simple defects saturates, and the production of more complex, cluster‐related defects grow. Majority of introduced defects are acceptor centers, which compensate n‐type (nitrogen) doping of the epilayer. The carrier removal rate increases with electron energy and follows well the classical nonionization energy loss (NIEL) scaling for electrons in silicon. The stability of introduced defects and their effect on carrier lifetime reduction are discussed, as well.

Constructing functionalized plasmonic gold/titanium dioxide nanosheets with small gold nanoparticles for efficient photocatalytic hydrogen evolution

Small plasmonic Au nanoparticles (NPs)-decorated with TiO2 nanosheets were fabricated to improve the photocatalytic performance. The Au/TiO2 nanosheets with Au NPs of different sizes ranging from ∼3 nm to 28 nm were prepared by using hydrothermally obtained TiO2 nanosheets as substrate via urea and light reduction method. During synthesis, the obtained Au NPs through urea reduction treatment in different calcination temperatures possessed smaller size (∼3–13 nm) than those of the light reduction method (∼28 nm). The introduced Au NPs were tightly loaded on the surface of TiO2 nanosheets through in situ growth reduction process of chloroauric acid. The emergence of smaller Au NPs promoted the photocatalytic performance over Au/TiO2 nanosheets. The as-prepared Au/TiO2 nanosheets with small Au NP sizes of ∼3–5 nm showed the highest photocatalytic rate of hydrogen production (∼230 µmol·h−1) under xenon lamp illumination, exceeding more than twice that of Au/TiO2 nanosheets with loading of larger Au NPs (∼28 nm). The favorable constituents and combination of Au/TiO2 nanosheets provided large surface adsorptive sites for reactant adsorption, introduced plasmonic effects and formed Schottky barrier junction via surface plasmon resonance. The Schottky barrier height was lower due to the presence of smaller Au NPs, thereby enhancing the charge separation through the Schottky transfer hub to neighboring TiO2 nanosheets. The synergistic effect between the plasmonic hot carrier-driven Au NPs and TiO2 nanosheets was discussed. The photocatalytic mechanism was also proposed for the fabrication of visible light-restricted photocatalysts with smaller Au NPs.

Influence of Trench Design on the Electrical Properties of 650V 4H-SiC JBS Diodes

This work presents a design study of customized p+ arrays having influence on the electrical properties of manufactured 4H-SiC Junction Barrier Schottky (JBS) diodes with designated electrical characteristics of 5 A forward and 650 V blocking capabilities. The effect of the Schottky area consuming p+ grid on the forward voltage drop, the leakage current and therefore the breakdown voltage was investigated. A recessed p+ implantation, realized through trench etching before implanting the bottom of the trenches, results in a more effective shielding of the electrical field at the Schottky interface and therefore reduces the leakage current. Customizing the p+ grid array in combination with the trench structure, various JBS diode variants with active areas of 1.69 mm2 were fabricated whereas forward voltage drops of 1.58 V @ 5 A with blocking capabilities up to 1 kV were achieved.

Radiation Effects on 1.7kV Class 4H-SiC Power Devices: Development of Compact Simulation Models

Compact simulation models of two key silicon carbide power components, the Junction Barrier Schottky diode and the power MOSFET, which are taking into account the effect of irradiation by highenergy electrons, were developed. Two 1.7 kV class devices: the 14 A JBS diode C3D10170H and the 5 A SiC power MOSFETs C2M1000170D produced by Wolfspeed were irradiated by 4.5 MeV electrons in the dose range up to 2000 kGy. Electrical characteristics were measured prior to and after irradiation. Radiation defects were studied by deep level transient spectroscopy and the effect of irradiation on device characteristics was established. SPICE models taking into account the irradiation fluence were proposed and calibrated using the parameters extracted from experiment. Simulated characteristics show a very good agreement with reality.

Mechanisms and Characteristics of Large-Area High-Current-Density 4H-SiC Trench Junction Barrier Schottky Diodes

Mechanisms and characteristics of optimized main junction for 4H-SiC trench junction barrier Schottky (TMJBS) diodes were investigated by theories and experiments. From these simulation and experimental values, we can conclude that TMJBS device has better reverse performance, such as the best reverse blocking capability and lowest reverse surface leakage current than the conventional JBS and TJBS device while maintaining good forward characteristics. Furthermore, The large area TMJBS Diodes with high current density show the better reverse characteristics than the small area one at an acceptable forward characteristics. The TMJBS structure can significantly reduce the influence of the Schottky interface and is more suitable for manufacturing high current density and large area devices.

High-performance photodetector using urchin-like hollow spheres of vanadium pentoxide network device

This paper investigates the properties of the urchin-like hollow spheres of vanadium pentoxide (UHS V2O5) network device. The device exhibited high photocurrent of μA with 102 rectification ratio under illumination due to the formation of a network device structure that reduced junction barrier and providing more electronic paths in our photodetector. The photovoltaic characteristics near zero bias were also observed when the device irradiated by 450 nm of 29.8 mW/cm2. The calculated open circuit voltage and short-circuit current were 0.26 V and 0.105 μA, respectively. The key performing parameters responsivity and specific detectivity of the fabricated device were (7.18-0.91) A/W and (5.94 × 1011-7.5 × 1010) Jones, respectively under the bias voltage of −5 V and an illumination power from (3.3–29.8) mW/cm2. The high-performance is attributed to the high-quality well-distributed UHS V2O5 network device that has more active sites and a large area of illumination that facilitate oxygen adsorption and desorption at the V2O5 surface.

Enhanced Charge Collection in SiC Power MOSFETs Demonstrated by Pulse-Laser Two-Photon Absorption SEE Experiments

A two-photon absorption technique is used to understand the mechanisms of single-event effects (SEEs) in silicon carbide power metal–oxide–field-effect transistors (MOSFETs) and power junction barrier Schottky diodes. The MOSFETs and diodes have similar structures enabling the identification of effects associated specifically with the parasitic bipolar structure that is present in the MOSFETs, but not the diodes. The collected charge in the diodes varies only with laser depth, whereas it varies with depth and lateral position in the MOSFETs. Optical simulations demonstrate that the variations in collected charge observed are from the semiconductor device structure and not from metal/passivation-induced reflection. The difference in the spatial dependence of collected charge between the MOSFET and diode is explained by bipolar amplification of the charge carriers in the MOSFETs. Technology computer-aided design (TCAD) device simulations extend this analysis to heavy-ion-induced charge collection. In addition, there is discussion comparing this analysis with experimental results from prior works that show enhanced charge collection resulting from heavy-ion irradiation.

GH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery

The blood-brain barrier (BBB) regulates the traffic of molecules into the central nervous system (CNS) and also limits the drug delivery. Due to their flexible properties, liposomes are an attractive tool to deliver drugs across the BBB. We previously characterized gH625, a peptide derived from Herpes simplex virus 1. The present study investigates the efficiency of liposomes functionalized on their surface with gH625 to promote the brain uptake of neuroprotective peptide PACAP (pituitary adenylate cyclase-activating polypeptide). Using a rat in vitro BBB model, we showed that the liposomes preparations were non-toxic for the endothelial cells, as assessed by analysis of tight junction protein ZO1 organization and barrier integrity. Next, we found that gH625 improves the transfer of liposomes across endothelial cell monolayers, resulting in both low cellular uptake and increased transport of PACAP. Finally, in vivo results demonstrated that gH625 ameliorates the efficiency of liposomes to deliver PACAP to the mouse brain after intravenous administration. gH625-liposomes improve both PACAP reaching and crossing the BBB, as showed by the higher number of brain cells labelled with PACAP. gH625-liposomes represent a promising strategy to deliver therapeutic agents to CNS and to provide an effective imaging and diagnostic tool for the brain.

Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy.

Tight junction barrier is critical to intestinal homeostasis. Applying antibiotics to treat infections is common in clinical practice, which may affect intestinal microbiota. Intestinal microbiota dysbiosis is involved in the occurrence of some gastrointestinal diseases. Therefore, this study was aimed to investigate the influence of antibiotics on intestinal tight junction barrier and the possible underlying mechanisms. Healthy adult female C57BL/6 mice were treated with a broad-spectrum antibiotic cocktail for 14 days. 16S rDNA Illumina sequencing and headspace gas chromatography-mass spectrometry (HS-GC/MS) were respectively used to analyze microbial community and to detect short-chain fatty acids (SCFAs) contents. In vivo intestinal paracellular permeability to fluorescein isothiocyanate-dextran (FITC-dextran) was measured. Protein expression was determined by immunoblotting. Immunofluoresence was applied to observe the distributions of ZO-1, LC3B and ASC. Antibiotics remarkably altered intestinal microbiota composition in healthy mice, accompanying reduced SCFAs’ concentrations. In addition, the intestinal tight junction barrier was disrupted by antibiotic treatment, as evidenced by increased intestinal paracellular permeability to FITC-dextran, decreased tight junction protein expressions, and disrupted ZO-1 morphology. Furthermore, NLRP3 inflammasome and autophagy were activated by antibiotic treatment. In conclusion, intestinal epithelial tight junction barrier dysfunction induced by antibiotics is associated with intestinal microbiota dysbiosis, activated NLRP3 inflammasome and autophagy in mice.

UV-assisted chemiresistors made with gold-modified ZnO nanorods to detect ozone gas at room temperature.

Two kinds of flexible ozone (O3) sensors were obtained by placing pristine ZnO nanorods and gold-modified ZnO nanorods (NRs) on a bi-axially oriented poly(ethylene terephthalate) substrate. The chemiresistive sensor is operated at typically 1V at room temperature under the UV-light illumination. The ZnO nanorods were prepared via a hydrothermal route and have a highly crystalline wurtzite structure, with diameters ranging between 70 and 300nm and a length varying from 1 to 3μm. The ZnO NRs were then coated with a ca. 10nm gold layer whose presence was confirmed with microscopy analysis. This sensor is found to be superior to detect ozone at a room temperature. Typical figures of merit include (a) a sensor response of 108 at 30ppb ozone for gold-modified ZnO NRs, and (b) a linear range that extends from 30 to 570ppb. The sensor is stable, reproducible and selective for O3 compared to other oxidizing and reducing gases. The enhanced performance induced by the modification of ZnO nanorods with thin layer of gold is attributed to the increased reaction kinetics compared to pristine ZnO NRs. The sensing mechanism is assumed to be based on the formation of a nano-Schottky type barrier junction at the interface between gold and ZnO. Graphical abstract Room temperature, flexible UV-enhanced gold modified ZnO nanorods can detect ppb levels of ozone.

Role of Endoplasmic Reticulum Stress-Autophagy Axis in Severe Burn-Induced Intestinal Tight Junction Barrier Dysfunction in Mice.

Severe burn injury induces intestinal barrier dysfunction; however, the underlying mechanisms remain elusive. Our previous studies have shown that the intestinal epithelial tight junction (TJ) barrier dysfunction is associated with both endoplasmic reticulum (ER) stress and autophagy in severely burned mice, but the precise role of ER stress and autophagy in the burn-induced intestinal TJ barrier dysfunction needs to be determined. In this study, female C57/BL6 mice were assigned randomly to either sham burn or 30% total body surface area (TBSA) full-thickness burn. The effects of ER stress and autophagy on the intestinal epithelial TJ barrier were validated by inducing or inhibiting both ER stress and autophagy in mice treated with sham burn or burn injury. The intestinal permeability, expression, and localization of TJ proteins, ER stress, and autophagy were assessed by physiological, morphological, and biochemical analyses. The results showed that inducing ER stress with tunicamycin or thapsigargin caused the activation of autophagy, the increase of intestinal permeability, as well as the reduction and reorganization of TJ proteins in the sham-burned mice, and aggravated the burn-induced activation of autophagy, increase of intestinal permeability, as well as the reduction and reorganization of TJ proteins. In contrast, inhibiting ER stress with 4-phenylbutyrate alleviated the burn-induced activation of autophagy, increase of intestinal permeability, as well as the reduction and reorganization of TJ proteins. In addition, inducing autophagy with rapamycin resulted in the increase of intestinal permeability, as well as the reduction and reorganization of TJ proteins in the sham-burned mice, and aggravated the burn-induced increase of intestinal permeability as well as the reduction and reorganization of TJ proteins. However, inhibiting autophagy with 3-methyladenine attenuated the burn-induced increase of intestinal permeability, as well as the reduction and reorganization TJ proteins. It is suggested that the ER stress-autophagy axis contributes to the intestinal epithelial TJ barrier dysfunction after severe burn injury.

Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition.

In recent years, much new data on intestinal alkaline phosphatase (IAP) have been published, and major breakthroughs have been disclosed. The aim of the present review is to critically analyze the publications released over the last 5 years. These breakthroughs include, for example, the direct implication of IAP in intestinal tight junction integrity and barrier function maintenance; chronic intestinal challenge with low concentrations of Salmonella generating long-lasting depletion of IAP and increased susceptibility to inflammation; the suggestion that genetic mutations in the IAP gene in humans contribute to some forms of chronic inflammatory diseases and loss of functional IAP along the gut and in stools; stool IAP as an early biomarker of incipient diabetes in humans; and omega-3 fatty acids as direct inducers of IAP in intestinal tissue. Many recent papers have also explored the prophylactic and therapeutic potential of IAP and other alkaline phosphatase (AP) isoforms in various experimental settings and diseases. Remarkably, nearly all data confirm the potent anti-inflammatory properties of (I)AP and the negative consequences of its inhibition on health. A simplified model of the body AP system integrating the IAP compartment is provided. Finally, the list of nutrients and food components stimulating IAP has continued to grow, thus emphasizing nutrition as a potent lever for limiting inflammation.