It were analyzed 25 cases of pemphigus vulgaris (PV) and 11 cases of benign pemphigoid of mucous membranes (PBMM), in relation to clinical and demographic characteristics, treatment and management. This is a descriptive study, in which the information was collected from the medical records of patients and through a clinical follow-up record. The mean sample age was 41.64 years, female gender was the most frequent (n = 26; 72.22%) and the jugal mucosa the most affected anatomic site (n = 20; 27.40%). Eight patients (22.22%) showed lesions on the skin located in the arms, scalp and perioral region and 7 (19.44%) showed lesions in the genital mucosa, nasal, ocular conjunctiva and pharyngeal. Eight patients (22.22%) were clinically reevaluated, 5 cases of PV and 3 cases of PBMM. Prednisone (systemic 10 to 60 mg/day) associated with Clobetasol propionate (0.05%) (topical) were therapies of choice for 7 patients. The follow-up ranged from 5 months to 5 years. The PV and PBMM are autoimmune lesions which often present the oral cavity as a first clinical manifestation site. Thus, studies investigating clinical features, diagnosis and management are of great importance for better optimization of its treatments.