DURING the active phase of the chronic nephrotic syndrome loss of protein in the urine is a factor in lowering the plasma proteins to the edema level (1). Another possibile cause is partial failure of albumin production (2). Careful attention to dietary protein and caloric intake, when supplemented by judicious restriction of salt and water, may do much to improve general nutrition (3–6) and control edema. Such measures are not very effective in maintaining an adequate level of plasma albumin but do offset serious inroads on tissue proteins. In seeking for more active stimulation of the protein anabolism of these individuals, one's attention is naturally drawn to certain remarkable effects of some of the androgenic steroids. It is now a well-established fact that testosterone acetate or propionate will cause retention of considerable amounts of nitrogen in the dog (7,8) and also in man (9–12). In some experiments of our own (unpublished data) this effect has continued for as long as 80 days and the retent...