Journal Of Medicine Research Articles

Abstracts from international Emergency Medicine journals

Editor’s note: EMJ has partnered with the journals of multiple international emergency medicine societies to share from each a highlighted research study, as selected by their editors. This edition will...

Left Atrial Low Voltage Areas Predicts Recurrence of Atrial Fibrillation after Catheter Ablation: A Meta-Analysis.

Low voltage areas (LVAs) on left atrial (LA) voltage mapping correlate with atrial fibrosis. However, there is no uniform standard for the definition of LVAs, or mapping techniques and mapping rhythms, so that the predictive value of left atrial LVAs for recurrence of atrial fibrillation (AF) is uncertain. This study aimed to explore the relationship between the presence of pre-ablation left atrial LVAs and the risk of recurrent AF after catheter ablation. The databases of PubMed, Embase, Web of science, Cochrane library, Scopus, Wanfang Datebase, China National Knowledge Infrastructure, China Biology Medicine and China Scientific Journal Datebase were searched from inception to 31 July 2023. Relevant studies regarding left atrial LVAs prior to ablation to predict postoperative recurrence of AF were identified and analyzed. The efficacy endpoints were defined as the recurrence of atrial arrhythmia lasting over 30 s. A total of 12 studies with 1070 patients were included. We found the presence of pre-ablation left atrial LVAs correlated with the risk of recurrent AF after ablation (hazard ratio (HR) = 2.87, 95% confidence interval (CI): 2.33-3.52). The presence of pre-ablation left atrial LVAs can predict the risk of recurrent AF after ablation both in the follow-up duration ≤12 months group and follow-up duration >12 months group (follow-up duration ≤12 months: HR = 2.93, 95% CI: 2.20-3.90; follow-up duration >12 months: HR = 2.80, 95% CI: 2.09-3.77). The presence of pre-ablation left atrial LVAs correlated with the risk of recurrent AF after ablation in paroxysmal AF (HR = 2.89, 95% CI: 1.97-4.24). The presence of pre-ablation left atrial LVAs correlate with the risk of recurrent AF after catheter ablation.

Atezolizumab and bevacizumab in combination with TACE for patients with BCLC B HCC.

TPS584 Background: The combination of atezolizumab and bevacizumab (AB) is an effective regimen for patients with advanced HCC1. Moving effective systemic therapy to earlier stages of HCC is a priority in improving outcomes. Assessing the safety of the combination of AB and TACE is essential to evaluating this regimen. Methods: This is an open-label, single arm pilot study. The primary objective of this study is to examine the safety and tolerability of AB with TACE. The secondary objectives are response rate, time to progression, overall survival, time to TACE progression (TTTP), and time to untaceable progression. Approximately 24 patients will be enrolled. AB will be given every 3 weeks (A: 1200 mg; 15 mg/kg) weeks and TACE will be planned for each patient to be completed in up to 4 treatments. B will be held for cycles that are within 4 weeks before or after each TACE. Imaging will be every 8 weeks for the first year, then every 12 weeks for the second year. Based on data from the GO30140 and the IMbrave 150 studies, we assume the rate of grade 3 or higher AEs is approximately 55% for AB and will likely be higher with the addition of TACE. Safety will be continuously monitored using the Bayesian Predictive Probability (PP) approach2. The PP that the rate of grade 3 or higher AEs is related to the combination is greater than 70% by the end of the trial based on toxicity data in the current stage will be continuously updated. Inclusion criteria includes patients over 18 years old with an ECOG PS of 0 or 1, no cirrhosis or Child-Pugh A cirrhosis, diagnosis of HCC by imaging or biopsy, and EGD within 6 months with no evidence of gastroesophageal varices with bleeding or high risk of bleeding unless treated. Patients are excluded if they are candidates for curative intent therapy, have had hepatic encephalopathy in the last 12 months, have occlusion of the hepatic artery or main portal vein, or have history of significant autoimmune disease. 1. Finn, Richard S., et al. New England Journal of Medicine 382.20 (2020): 1894-1905. 2 Lee J and Liu D. Clinical Trials. 2008; 5(2): 93-106. Clinical trial information: NCT05776875 .

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Fair Use of Augmented Intelligence and Artificial Intelligence in the Preparation and Review of Submissions to the Society of Critical Care Medicine Journals: Critical Care Medicine, Pediatric Critical Care Medicine, and Critical Care Explorations.

Thoracic and abdominal aortic dissection in a hypertensive hyperthyroid cat

Aortic dissection is an uncommon finding in both dogs and cats. The precise pathophysiological mechanisms responsible for the development of aortic dissection remain unclear. In humans, aortic dissection is usually secondary to another systemic disease, such as systemic arterial hypertension, an abnormality of connective tissues or a parietal trauma. This is a case of an aortic dissection in a hypertensive hyperthyroid cat, presenting with haemorrhagic pericardial effusion. The dissection affected both thoracic and abdominal aorta, with histopathological confirmation. This case is an example of the utility of both thoracic and abdominal ultrasound for the diagnosis of aortic dissection in cats and it highlights the importance of rigorous clinical examination. Aortic dissection should be considered in the differential diagnosis of pericardial effusion in cats. Further investigations are fundamental to understand how dissections develop and extend to achieve good clinical results.
 REFERENCES
 
 Braverman et al. (2012) Diseases of the aorta. In: Braunwald’s Heart Disease. A textbook of cardiovascular medicine. 9th Eds Bonow R, Mann D, Zipes D, Libby P. Elsevier Saunders, Philadelphia, pp 1319-1331.
 Chetboul et al. (2006) Quantitative assessment of velocities of the annulus of the left atrioventricular valve and left ventricular free wall in healthy cats by use of two-dimensional colour tissue Doppler imaging. Am. J. Vet. Res. 2006, 67: 250-258.
 Cojocaru et al. (2013) Evaluation of oxidative stress in patients with acute ischemic stroke. Romanian Journal of Internal Medicine. 51(2):97-106.
 D’Ancona et al. (2014) Computational analysis to predict false-lumen perfusion and outcome of type B aortic dissection. The Journal of Thoracic and Cardiovascular Surgery. 148 (4):1756-1758.
 Gouni et al. (2018) Aortic dissecting aneurysm associated with systemic arterial hypertension in a cat. Schweiz Arch Tierheilkd. 160(5):320-324.
 Liao et al. (2008) A proteomic study of the aortic media in human thoracic aortic dissection: implication for oxidative stress. Journal of Thoracic and Cardiovascular Surgery. 136(1):65-72.
 Liu et al. (2016) Ursodeoxycholic acid attenuates acute aortic dissection formation in angiotensin II-infused apolipoprotein E-deficient mice associated with reduced ROS and increased Nrf2 levels. Cellular Physiology and Biochemistry. 38(4): 1391-1405.
 Phillippi et al. (2009) Basal and oxidative stress-induced expression of metallothionein is decreased in ascending aortic aneurysms of bicuspid aortic valve patients. Circulation. 119(18):2498-2506.
 Qin et al. (2016) Dynamic monitoring of platelet activation and its role in post-dissection inflammation in a canine model of acute type A aortic dissection. Journal of Cardiothoracic Surgery. 11(1):86.
 Qing et al. (2012) Ex-vivo haemodynamic models for the study of Stanford type B aortic dissection in isolated porcine aorta. European Journal of Vascular and Endovascular Surgery. 44(4):399-405.
 Waldrop et al. (2003) Aortic dissection associated with aortic aneurysms and posterior paresis in a dog. Journal of Veterinary Internal Medicine. 17(2):223-229.
 Wang et al. (2013) An experimental model of Stanford type B aortic dissection with intravenous epinephrine injection. Kaohsiung Journal of Medical Sciences. 29(4):194-199.
 Wey AC, Atkins CE (2000). Aortic dissection and congestive heart failure associated with systemic hypertension in a cat. Journal of Veterinary Internal Medicine. 14(2):208-213.

A Brief Guide to Citation Practices for Authors at the Malaysian Journal of Medicine and Health Sciences Submissions

No abstarct available

Study: Counterfeits/fentanyl making drug use more deadly for adolescents

As Scott E. Hadland, M.D., senior author of a dramatic paper published last week in the New England Journal of Medicine puts it, drug use among adolescents is not getting more common — it's at its lowest in almost 50 years. But it's getting more deadly, due to fentanyl. In “The Overdose Crisis among U.S. Adolescents,” by Hadland and lead author Joseph Friedman, Ph.D., the problem is laid out clearly: After guns and car crashes, overdose (OD) deaths are now the third leading cause of death among adolescents.

Evaluating GPT-4-based ChatGPT's clinical potential on the NEJM quiz

BackgroundGPT-4-based ChatGPT demonstrates significant potential in various industries; however, its potential clinical applications remain largely unexplored.MethodsWe employed the New England Journal of Medicine (NEJM) quiz “Image Challenge” from October 2021 to March 2023 to assess ChatGPT's clinical capabilities. The quiz, designed for healthcare professionals, tests the ability to analyze clinical scenarios and make appropriate decisions. We evaluated ChatGPT's performance on the NEJM quiz, analyzing its accuracy rate by questioning type and specialty after excluding quizzes which were impossible to answer without images. ChatGPT was first asked to answer without the five multiple-choice options, and then after being given the options.ResultsChatGPT achieved an 87% (54/62) accuracy without choices and a 97% (60/62) accuracy with choices, after excluding 16 image-based quizzes. Upon analyzing performance by quiz type, ChatGPT excelled in the Diagnosis category, attaining 89% (49/55) accuracy without choices and 98% (54/55) with choices. Although other categories featured fewer cases, ChatGPT's performance remained consistent. It demonstrated strong performance across the majority of medical specialties; however, Genetics had the lowest accuracy at 67% (2/3).ConclusionChatGPT demonstrates potential for diagnostic applications, suggesting its usefulness in supporting healthcare professionals in making differential diagnoses and enhancing AI-driven healthcare.

Clinical Research in Renal Transplantation: A Bibliometric Perspective on a Half-century of Innovation and Progress.

Groundbreaking biomedical research has transformed renal transplantation (RT) into a widespread clinical procedure that represents the mainstay of treatment for end-stage kidney failure today. Here, we aimed to provide a comprehensive bibliometric perspective on the last half-century of innovation in clinical RT. The Web of Science Core Collection was used for a comprehensive screening yielding 123 303 research items during a 50-y period (January 1973-October 2022). The final data set of the 200 most-cited articles was selected on the basis of a citation-based strategy aiming to minimize bias. Studies on clinical and immunological outcomes (n = 63 and 48), registry-based epi research (n = 38), and randomized controlled trials (n = 35) dominated the data set. Lead US authors have signed 110 of 200 articles. The overall level of evidence was high, with 84% of level1 and -2 reports. Highest numbers of these articles were published in New England Journal of Medicine , Transplantation , and American Journal of Transplantation. Increasing trend was observed in the number of female authors in the postmillennial era (26% versus 7%). This study highlights important trends in RT research of the past half-century. This bibliometric perspective identifies the most intensively researched areas and shift of research interests over time; however, it also describes important imbalances in distribution of academic prolificacy based on topic, geographical aspects, and gender.

The LEAP checklist for laboratory evaluation and analytical performance characteristics reporting of clinical measurement procedures

Reporting a measurement procedure and its analytical performance following method evaluation in a peer-reviewed journal is an important means for clinical laboratory practitioners to share their findings. It also represents an important source of evidence base to help others make informed decisions about their practice. At present, there are significant variations in the information reported in laboratory medicine journal publications describing the analytical performance of measurement procedures. These variations also challenge authors, readers, reviewers, and editors in deciding the quality of a submitted manuscript.The International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Method Evaluation Protocols (IFCC WG-MEP) developed a checklist and recommends its adoption to enable a consistent approach to reporting method evaluation and analytical performance characteristics of measurement procedures in laboratory medicine journals. It is envisioned that the LEAP checklist will improve the standardisation of journal publications describing method evaluation and analytical performance characteristics, improving the quality of the evidence base that is relied upon by practitioners.

In Case You Haven't Heard…

Can a wearable device change depression care? About one third of U.S. adults use a wearable device (for example, a smartwatch) to track their health and fitness, according to an APA Psychiatric News Alert news release. These devices — also known as “wearables”— capture a large amount of information that could be used one day to enhance how depression is diagnosed, monitored and treated, wrote Szymon Fedor, Ph.D., of the MIT Media Lab and colleagues from Massachusetts General Hospital in a review article in The New England Journal of Medicine. As the authors explained, the diagnosis and monitoring of depression today is based largely on symptoms reported by patients, which is subjective. However, wearables provide objective information by passively collecting physiological and behavioral information, that is, users do not need to input this information. “Complementing patient self‐reports, … measurements [from wearables] increase the information available for differential diagnosis or treatment planning,” they wrote. Additionally, “longitudinal measurements help establish patient‐specific behavioral and physiological baselines and support identification of personalized factors that result in deviations from these norms.” Data obtained from a patient's wearable could also influence how clinicians structure their time during visits with the patient, they continued. “In this proposed scenario, clinicians could use their limited time with patients more efficiently, gathering insights not provided by a wearable, thus forming a better therapeutic relationship and delivering personalized treatment.”

The Journal of Physical Fitness and Sports Medicine, Vol. 13, No. 3

The Journal of Physical Fitness and Sports Medicine, Vol. 13, No. 3

Ab. No. 148 Global Research Trends on Gait Rehabilitation in Individuals With Spinal Cord Injury- A Bibliometric Analysis

Introduction: This bibliometric analysis aims to comprehensively assess the literature related to gait rehabilitation for individuals with spinal cord injury (SCI) to identify significant contributors, and to explore the collaborations and emerging themes in the field. This study helps to assess the scientific evolution of the field that occurs with technological advancements. Gait rehabilitation following SCI requires a multi-disciplinary approach and the current analysis will assess the global collaborations and provide insights for policymakers, funders, publishers, and future researchers. Methods: The Clarivate Web of Science Citation Index Expanded database was searched using the keywords (“gait” OR “walking” OR “locomot* OR “Ambulat*”) AND (Spinal cord injur*)” for all original and review English articles that were published from the inception of the database till date. The data from the selected articles were imported into R software, and bibliometric indicators were assessed to determine author contributions, country affiliations, journal sources, and thematic trends. Results: A total of 1313 pertinent articles were found, with the USA leading in contributions to SCI gait rehabilitation research. Other notable contributors include Canada and Switzerland. Key journals include Spinal Cord, Archives of Physical Medicine and Rehabilitation, Journal of Spinal Cord Medicine, Journal of NeuroEngineering, and Journal of Neurotrauma. Leading contributors are Northwestern University, the University of Miami, and the University of Alberta. The analysis indicates a growing interest in gait rehabilitation research post-2000, emphasizing interdisciplinary approaches and emerging technologies such as robotics, exoskeletons, and neuromodulation. Conclusion: The analysis underscores the significance of collaborative and interdisciplinary research in gait rehabilitation, revealing a shift from traditional methods to technology integration. Notably, publications from the USA and Europe have a substantial impact, emphasizing the increasing focus on technology-driven approaches and understanding neuroplasticity in gait rehabilitation.

The Journal of Respiratory Biology and Translational Medicine, a Versatile Platform for Basic and Clinical Science

The Journal of Respiratory Biology and Translational Medicine, a Versatile Platform for Basic and Clinical Science

Global Research Trends on Exosome in Cardiovascular Diseases: A Bibliometric-Based Visual Analysis.

Exosomes in cardiovascular diseases (CVDs) have attracted huge attention with substantial value and potential. Our bibliometrics is based on literature from the field of cardiovascular exosomes over the past 30 years, which has been visualized to display the development process, research hotspots, and cutting-edge trends of clinical practices, mechanisms, and management strategies related to psych cardiology. We selected articles and reviews on exosomes in CVDs from the core collection of Web of Science, and generated visual charts by using CiteSpace and VOSviewer software. Our research included 1613 publications. The number of exosome articles in CVD fluctuates slightly, but overall shows an increasing trend. The main research institutions were Tongji University and Nanjing Medical University. The International Journal of Molecular Sciences has the highest publication volume, while the Journal of Cellular and Molecular Medicine has the highest citation count. Among all the authors, Eduardo Marban ranks first in terms of publication volume and H-index. The most common keywords are exosome, extracellular vesicles, and angiogenesis. This is a bibliometric study on the research hotspots and trends of exosomes in CVD. Exosome research in the field of cardiovascular medicine is on the rise. Some exosome treatment methods may become the focus of future research.

A list of articles in the past issues of ABC journal of emergency medicine

A list of articles in the past issues of ABC journal of emergency medicine

The Journal of Physical Fitness and Sports Medicine, Vol. 13, No. 5

The Journal of Physical Fitness and Sports Medicine, Vol. 13, No. 5

Global trends and performances of infrared imaging technology studies on acupuncture: a bibliometric analysis.

To summarize development processes and research hotspots of infrared imaging technology research on acupuncture and to provide new insights for researchers in future studies. Publications regarding infrared imaging technology in acupuncture from 2008 to 2023 were downloaded from the Web of Science Core Collection (WoSCC). VOSviewer 1.6.19, CiteSpace 6.2.R4, Scimago Graphica, and Microsoft Excel software were used for bibliometric analyses. The main analyses include collaboration analyses between countries, institutions, authors, and journals, as well as analyses on keywords and references. A total of 346 publications were retrieved from 2008 to 2023. The quantity of yearly publications increased steadily, with some fluctuations over the past 15 years. "Evidence-Based Complementary and Alternative Medicine" and "American Journal of Chinese Medicine" were the top-cited journals in frequency and centrality. China has the largest number of publications, with the Shanghai University of Traditional Chinese Medicine being the most prolific institution. Among authors, Litscher Gerhard from Austria (currently Swiss University of Traditional Chinese Medicine, Switzerland) in Europe, was the most published and most cited author. The article published by Rojas RF was the most discussed among the cited references. Common keywords included "Acupuncture," "Near infrared spectroscopy," and "Temperature," among others. Explore the relationship between acupoints and temperature through infrared thermography technology (IRT), evaluate pain objectively by functional near-infrared spectroscopy (fNIRS), and explore acupuncture for functional connectivity between brain regions were the hotspots and frontier trends in this field. This study is the first to use bibliometric methods to explore the hotspots and cutting-edge issues in the application of infrared imaging technology in the field of acupuncture. It offers a fresh perspective on infrared imaging technology research on acupuncture and gives scholars useful data to determine the field's hotspots, present state of affairs, and frontier trends.