Toxicology Journals Research Articles

Polycyclic Aromatic Hydrocarbons in Carcinogenesis

Polycyclic Aromatic Hydrocarbons in Carcinogenesis

Increased Level of TGF-p2 in Patients with Primary Open-Angle Glaucoma is Implicated in the Pathogenesis of the Disease

(1999). Increased Level of TGF-p2 in Patients with Primary Open-Angle Glaucoma is Implicated in the Pathogenesis of the Disease. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 18, No. 3, pp. 266-267.

Phototoxic Retinal Lesion Caused by Occupational Exposure to an Old-Style Movie Projector

(1999). Phototoxic Retinal Lesion Caused by Occupational Exposure to an Old-Style Movie Projector. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 18, No. 3, pp. 264-264.

Clinical and Histological Ocular Limbic Findings After Mercuric Chloride Administration in BN Rats

(1999). Clinical and Histological Ocular Limbic Findings After Mercuric Chloride Administration in BN Rats. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 18, No. 3, pp. 274-275.

A Review of the Epidemiological Data on the Use of Crude Coal Tar as a Medicament for Psoriasis, Atopy, and Seborrheic Dermatitis

(1999). A Review of the Epidemiological Data on the Use of Crude Coal Tar as a Medicament for Psoriasis, Atopy, and Seborrheic Dermatitis. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 18, No. 2, pp. 155-159.

The First International Conference on the Environmental Health and Safety of Jet Fuel

The First International Conference on the Environmental Health and Safety of Jet Fuel

No Safe Harbor

Research ArticleOpen AccessNo safe harbor. W C Holton W C Holton Search for more papers by this author Published:1 May 1998https://doi.org/10.1289/ehp.98106a228Cited by:1AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited By Belluck D, Benjamin S, Baveye P, Sampson J and Johnson B (2016) Widespread Arsenic Contamination of Soils in Residential Areas and Public Spaces: An Emerging Regulatory or Medical Crisis?, International Journal of Toxicology, 10.1080/10915810305087, 22:2, (109-128), Online publication date: 1-Mar-2003. Vol. 106, No. 5 May 1998Metrics About Article Metrics Publication History Originally published1 May 1998Published in print1 May 1998 Financial disclosures License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Smokable drugs: pharmacologic basis for consumer appeal

AddictionVolume 92, Issue 6 p. 691-692 Free Access Smokable drugs: pharmacologic basis for consumer appeal Wallace B. Pickworth, Wallace B. Pickworth Clinical Pharmacology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.Search for more papers by this authorJack E. Henningfield, Jack E. Henningfield Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Medicine, Behavioral Biology Research Center, Baltimore, MD and Pinney Associates, Bethesda, MD, USA.Search for more papers by this author Wallace B. Pickworth, Wallace B. Pickworth Clinical Pharmacology Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA.Search for more papers by this authorJack E. Henningfield, Jack E. Henningfield Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Medicine, Behavioral Biology Research Center, Baltimore, MD and Pinney Associates, Bethesda, MD, USA.Search for more papers by this author First published: 24 January 2006 https://doi.org/10.1111/j.1360-0443.1997.tb02934.xCitations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References Benowitz, N. L. (1990) Clinical pharmacology of inhaled drugs of abuse: implications in understanding nicotine dependence, NIDA Research Monograph No. 99. Research Findings on Smoking of Abused Substances, pp. 12 – 29 ( Washington , DC , US Government Printing Office). Cone, E. J. (1995) Pharmacokinetics and pharmacodynamics of cocaine. Journal of Analytical Toxicology, 19, 459 – 478. de Wit, H., Bodker, B. & Ambre, J. (1992) Rate of increase of plasma drug level influences subjective response in humans. Psychopharmacology, 107, 352 – 358. Hatsukami, D., Keenan, R., Carroll, M. et al. (1990) A method for delivery of precise doses of smoked cocaine-base to humans. Pharmacology Biochemistry and Behavior, 36, 1 – 7. Henningfield, J. E., Stapleton, J. M., Benowitz, N. L., Grayson, R. F. & London, E. D. (1993) Higher levels of nicotine in arterial than in venous blood after cigarette smoking. Drug and Alcohol Dependence, 33, 23 – 29. Henningfield, J. E. & Keenan, R. M. (1993) Nicotine delivery kinetics and abuse liability. Journal of Consulting and Clinical Psychology, 61, 743 – 750. Jenkins, A. J., Keenan, R. M., Henningfield, J. E. & Cone, E. J. (1994) Pharmacokinetics and pharmacodynamics of smoked heroin. Journal of Analytical Toxicology, 18, 317 – 330. Pickworth, W. B., Keenan, R. M. & Henningfield, J. E. (1995) Nicotine: effects and mechanisms in: L. W. Chang & R. S. Dyer, (Eds) Handbook of Neurotoxicology, pp. 801 – 824 (Marcel Decker, New York ). Rose, J. E. & Levin, E. D. (1991) Inter-relationships between conditioned and primary reinforcement in the maintenance of cigarette smoking. British Journal of Addiction, 86, 605 – 609. Strang, J., Griffiths, P. & Gossop, M. (1997) Heroin smoking by ‘chasing the dragon’: origins and history. Addiction, 92, 673 – 683. Wesson, D. R. & Washburn, P. (1990) Current patterns of drug abuse that involve smoking, NIDA Research Monograph No. 99. Research Findings on Smoking of Abused Substances, pp. 5 – 11 ( Washington , DC , US Government Printing Office). Citing Literature Volume92, Issue6June 1997Pages 691-692 ReferencesRelatedInformation

A New Commitment by the American Academy of Clinical Toxicology and the European Association of Poisons Centres and Clinical Toxicologists to theJournal of Toxicology-Clinical Toxicology

AbstractThe discipline of clinical toxicology has evolved from the art of identifying and managing common poisoning emergencies to an evidence-based specialty. In the main, the important early challenges which involved gastrointestinal decontamination and the specific treatment of medication-related poisonings (e.g., N-acetylcysteine for acetaminophen poisoning) have been met and have led to improvement in patient care. Clinical toxicologists must now begin to address the new challenges:namely, exposure to industrial, agricultural, and environmental chemicals. Thousands of new chemical compounds are developed each year. For many, we do not know the mechanism of toxicity, the long-term sequelae from exposure, or the appropriate management of toxicity.

Current status of conducting function tests in repeated dose toxicity studies in Japan.

It seems desirable to conduct as many function tests as possible in repeated dose toxicity studies, but is it practicable? The current status of conducting function tests in repeated dose toxicity studies in Japan was investigated by a literature survey of more than one thousand papers published in seven Japanese toxicology journals during the past 10 years and by a questionnaire survey directed to toxicologists among the Japan Pharmaceutical Manufacturers Association (JPMA) member companies. The function tests often carried out in repeated dose toxicity studies were, for example: 1) electro-retinography (ERG) and visually evoked potential (VEP) for visual test and tonometer for intraocular pressure; 2) auricular reflex, evoked response audiometry (ERA) and auditory brainstem response (ABR) to sound stimuli; 3) respiration and heart rate, electrocardiogram (ECG) and blood pressure by noninvasive cuff methods or using electronic devices such as telemetry; 4) body temperature, spontaneous motility and some adaptation tests (using rotarod and sloped plate in rats); 5) indocyanin (ICG) or bromosulfophtalein (BSP) for hepatic test; 6) phenolsulfonphtalein (PSP) and creatinine clearance for renal test; and 7) immunoglobulin, leukocyte phagocytosis, lymphocyte blastgenesis and natural killer cell (NK) for immuno-reaction test. Limitations to conducting function tests in repeated dose toxicity studies and issues to be resolved were discussed, based on questions and suggestions given by the respondents to the questionnaire. Although it certainly seemed desirable to conduct as many function tests as possible in repeated dose toxicity studies, most of the function tests so far introduced into toxicity studies were not satisfactory, because those tests could not be carried out under the restricted conditions of repeated dose toxicity studies, and not much reliable data from function tests were obtainable. A variety of function tests should firstly be incorporated into single dose toxicity studies together with development of a new concept for methodology in safety pharmacology.

Erratum

"Erratum." Journal of Toxicology and Environmental Health, 49(3), p. 339This article refers to:

Nicotine Poisoning as a Cause of Cardiac Arrest?

(1996). Nicotine Poisoning as a Cause of Cardiac Arrest? Journal of Toxicology: Clinical Toxicology: Vol. 34, No. 4, pp. 475-476.

Alternatives to Animal Testing

(1996). Alternatives to Animal Testing. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 15, No. 1, pp. 29-31.

Naturally Occurring Teratogens

(1996). Naturally Occurring Teratogens. Journal of Toxicology: Toxin Reviews: Vol. 15, No. 4, pp. 369-391.

Acute Dystonia in a Child Associated with Therapeutic Ingestion of a Dextromethorphan Containing Cough and Cold Syrup

(1996). Acute Dystonia in a Child Associated with Therapeutic Ingestion of a Dextromethorphan Containing Cough and Cold Syrup. Journal of Toxicology: Clinical Toxicology: Vol. 34, No. 3, pp. 351-352.

Role of Chelating Agents for Prevention, Intervention, and Treatment of Exposures to Toxic Metals

Role of Chelating Agents for Prevention, Intervention, and Treatment of Exposures to Toxic Metals

Symposium on estrogens in the environment, III.

Symposium on estrogens in the environment, III.

Itch: Mechanisms and Management of Pruritus, edited by J. D. Bernhard, McGraw Hill, New York, 1994. 454 pages, soft cover, $52.00

(1995). Itch: Mechanisms and Management of Pruritus, edited by J. D. Bernhard, McGraw Hill, New York, 1994. 454 pages, soft cover, $52.00. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 14, No. 4, pp. 309-310.

Toxicology Elsewhere

The purpose of this section in Human and Experimental Toxicology is to draw attention to papers that are of significance to toxicologists but may be missed because, in the main, they have not been published in mainstream toxicology journals. In addition the papers selected attempt to reflect topics of the liveliest current research interest as well as those which impinge upon the professional practice of toxicology. In order to assist the assimilation of such new material an expert commentary is provided and because these aim to focus succinctly on the advance made they should also serve as mini-reviews to keep us all abreast of our rapidly developing, multi-disciplinary, subject. In this issue the focus is upon animal models which may advance knowledge of mechanisms of chemical carcinogenesis.

Toxicology Elsewhere

The purpose of this section in Human and Experimental Toxicology is to draw attention to papers that are of significance to toxicologists but may be missed because, in the main, they have not been published in mainstream toxicology journals. In addition the papers selected attempt to reflect topics of the liveliest current research interest as well as those which impinge upon the professional practice of toxicology. In order to assist the assimilation of such new material an expert commentary is provided and because these aim to focus succinctly on the advance made they should also serve as mini-reviews to keep us all abreast of our rapidly developing, multi-disciplinary, subject.