Journal Of Cognitive Neuroscience Research Articles

Perceptual Training as Means to Assess the Effect of Alpha Frequency on Temporal Binding Window.

For decades, it has been shown that alpha frequency is related to temporal binding window, and currently, such is the mainstream viewpoint [Noguchi, Y. Individual differences in beta frequency correlate with the audio-visual fusion illusion. Psychophysiology, 59, e14041, 2022; Gray, M. J., & Emmanouil, T. A. Individual alpha frequency increases during a task but is unchanged by alpha-band flicker. Psychophysiology, 57, e13480, 2020; Hirst, R. J., McGovern, D. P., Setti, A., Shams, L., & Newell, F. N. What you see is what you hear: Twenty years of research using the sound-induced flash illusion. Neuroscience & Biobehavioral Reviews, 118, 759-774, 2020; Keil, J. Double flash illusions: Current findings and future directions. Frontiers in Neuroscience, 14, 298, 2020; Migliorati, D., Zappasodi, F., Perrucci, M. G., Donno, B., Northoff, G., Romei, V., & Costantini, M. Individual alpha frequency predicts perceived visuotactile simultaneity. Journal of Cognitive Neuroscience, 32, 1-11, 2020; Keil, J., & Senkowski, D. Individual alpha frequency relates to the sound-induced flash illusion. Multisensory Research, 30, 565-578, 2017; Minami, S., & Amano, K. Illusory jitter perceived at the frequency of alpha oscillations. Current Biology, 27, 2344-2351, 2017; Cecere, R., Rees, G., & Romei, V. Individual differences in alpha frequency drive crossmodal illusory perception. Current Biology, 25, 231-235, 2015]. However, recently, this stance has been challenged [Buergers, S., & Noppeney, U. The role of alpha oscillations in temporal binding within and across the senses. Nature Human Behaviour, 6, 732-742, 2022]. Moreover, both stances appear to have their limitations regarding the reliability of results. Therefore, it is of paramount importance to develop new methodology to gain more reliable results. Perceptual training seems to be such a method that also offers significant practical implications.

Multiple mechanisms of visual prediction as revealed by the timecourse of scene-object facilitation.

Not only semantic, but also recently learned arbitrary associations have the potential to facilitate visual processing in everyday life-for example, knowledge of a (moveable) object's location at a specific time may facilitate visual processing of that object. In our prior work, we showed that previewing a scene can facilitate processing of recently associated objects at the level of visual analysis (Smith and Federmeier in Journal of Cognitive Neuroscience, 32(5):783-803, 2020). In the current study, we assess how rapidly this facilitation unfolds by manipulating scene preview duration. We then compare our results to studies using well-learned object-scene associations in a first-pass assessment of whether systems consolidation might speed up high-level visual prediction. In two ERP experiments (N = 60), we had participants study categorically organized novel object-scene pairs in an explicit paired associate learning task. At test, we varied contextual pre-exposure duration, both between (200 vs. 2500 ms) and within subjects (0-2500 ms). We examined the N300, an event-related potential component linked to high-level visual processing of objects and scenes and found that N300 effects of scene congruity increase with longer scene previews, up to approximately 1-2 s. Similar results were obtained for response times and in a separate component-neutral ERP analysis of visual template matching. Our findings contrast with prior evidence that scenes can rapidly facilitate visual processing of commonly associated objects. This raises the possibility that systems consolidation might mediate different kinds of predictive processing with different temporal profiles.

Memory Consolidation during Ultra-short Offline States.

Traditionally, neuroscience and psychology have studied the human brain during periods of "online" attention to the environment, while participants actively engage in processing sensory stimuli. However, emerging evidence shows that the waking brain also intermittently enters an "offline" state, during which sensory processing is inhibited and our attention shifts inward. In fact, humans may spend up to half of their waking hours offline [Wamsley, E. J., & Summer, T. Spontaneous entry into an "offline" state during wakefulness: A mechanism of memory consolidation? Journal of Cognitive Neuroscience, 32, 1714-1734, 2020; Killingsworth, M. A., & Gilbert, D. T. A wandering mind is an unhappy mind. Science, 330, 932, 2010]. The function of alternating between online and offline forms of wakefulness remains unknown. We hypothesized that rapidly switching between online and offline states enables the brain to alternate between the competing demands of encoding new information and consolidating already-encoded information. A total of 46 participants (34 female) trained on a memory task just before a 30-min retention interval, during which they completed a simple attention task while undergoing simultaneous high-density EEG and pupillometry recording. We used a data-driven method to parse this retention interval into a sequence of discrete online and offline states, with a 5-sec temporal resolution. We found evidence for three distinct states, one of which was an offline state with features well-suited to support memory consolidation, including increased EEG slow oscillation power, reduced attention to the external environment, and increased pupil diameter (a proxy for increased norepinephrine). Participants who spent more time in this offline state following encoding showed improved memory at delayed test. These observations are consistent with the hypothesis that even brief, seconds-long entry into an offline state may support the early stages of memory consolidation.

Disentangling Some Conceptual Knots.

Disentangling Some Conceptual Knots.

Promoting inclusion, diversity, and equity in pain science.

Promoting inclusion, diversity, and equity in pain science.

Promoting Inclusion, Diversity, and Equity in Pain Science.

Promoting Inclusion, Diversity, and Equity in Pain Science.

Promoting inclusion, diversity, and equity in pain science

Promoting inclusion, diversity, and equity in pain science

Foreground and Background in Mental Models.

Foreground and Background in Mental Models.

Developments in Transcranial Magnetic Stimulation to Study Human Cognition.

Developments in Transcranial Magnetic Stimulation to Study Human Cognition.

Get Stoke(s)d! Introduction to the Special Focus.

Get Stoke(s)d! Introduction to the Special Focus.

What the Flip? What the P-N Flip Can Tell Us about Proactive Suppression.

It has been debated whether salient distractors in visual search can be proactively suppressed to completely prevent attentional capture, as the occurrence of proactive suppression implies that the initial shift of attention is not entirely driven by physical salience. While the presence of a Pd component in the EEG (associated with suppression) without a preceding N2pc component (associated with selection) has been used as evidence for proactive suppression, the link between these ERPs and the underlying mechanisms is not always clear. This is exemplified in two recent articles that observed the same waveform pattern, where an early Pd-like component flipped to a N2pc-like component, but provided vastly different interpretations (Drisdelle, B. L., & Eimer, E. PD components and distractor inhibition in visual search: New evidence for the signal suppression hypothesis. Psychophysiology, 58, e13898, 2021; Kerzel, D., & Burra, N. Capture by context elements, not attentional suppression of distractors, explains the PD with small search displays. Journal of Cognitive Neuroscience, 32, 1170-1183, 2020). Using RAGNAROC (Wyble et al., Understanding visual attention with RAGNAROC: A Reflexive Attention Gradient through Neural AttRactOr Competition. Psychological Review, 127, 1163-1198, 2020), a computational model of reflexive attention, we successfully simulated this ERP pattern with minimal changes to its existing architecture, providing a parsimonious and mechanistic explanation for this flip in the EEG that is unique from both of the previous interpretations. Our account supports the occurrence of proactive suppression and demonstrates the benefits of incorporating computational modeling into theory building.

Assessing the Degree of Ecological Validity of Your Study: Introducing the Multidimensional Assessment of Research in Context (MARC) Tool

ABSTRACTIn cognitive neurosciences, fundamental principles of mental processes and functional brain organization have been established with highly controlled tasks and testing environments. Recent technical advances allowed the investigation of these functions and their brain mechanisms in naturalistic settings. The diversity in those approaches have been recently (Matusz, P. J., Dikker, S., Huth, A. G., & Perrodin, C. (2019). Are we ready for real‐world neuroscience? Journal of Cognitive Neuroscience, 31(3), 327–338. doi:10.1162/jocn_e_01276) classified via a three‐category cycle, including controlled laboratory, partially naturalistic laboratory, and naturalistic real‐world research. Based on this model, we developed the Multidimensional Assessment of Research in Context (MARC) tool to easily delineate the approach researchers have taken in their study. MARC provides means to describe the degree of ecological validity for each component of a study (e.g., sample, stimuli, measures, etc.), and the study's location on the cycle. The tool comprises seven questions concerning a study's characteristics. It outputs a summary of those and a compass plot, which can be used for presentations, preregistration, grant proposals, and papers. It aims to improve drawing conclusions across studies and raise awareness about the generalizability of research findings.

Effects of tDCS on the attentional blink revisited: A statistical evaluation of a replication attempt.

The attentional blink (AB) phenomenon reveals a bottleneck of human information processing: the second of two targets is often missed when they are presented in rapid succession among distractors. In our previous work, we showed that the size of the AB can be changed by applying transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) (London & Slagter, Journal of Cognitive Neuroscience, 33, 756-68, 2021). Although AB size at the group level remained unchanged, the effects of anodal and cathodal tDCS were negatively correlated: if a given individual's AB size decreased from baseline during anodal tDCS, their AB size would increase during cathodal tDCS, and vice versa. Here, we attempted to replicate this finding. We found no group effects of tDCS, as in the original study, but we no longer found a significant negative correlation. We present a series of statistical measures of replication success, all of which confirm that both studies are not in agreement. First, the correlation here is significantly smaller than a conservative estimate of the original correlation. Second, the difference between the correlations is greater than expected due to sampling error, and our data are more consistent with a zero-effect than with the original estimate. Finally, the overall effect when combining both studies is small and not significant. Our findings thus indicate that the effects of lDPLFC-tDCS on the AB are less substantial than observed in our initial study. Although this should be quite a common scenario, null findings can be difficult to interpret and are still under-represented in the brain stimulation and cognitive neuroscience literatures. An important auxiliary goal of this paper is therefore to provide a tutorial for other researchers, to maximize the evidential value from null findings.

A Commentary on “Can Neuroscience Provide a New Foundation for the Rorschach Variables?” (Jimura et al., 2021)

A Commentary on “Can Neuroscience Provide a New Foundation for the Rorschach Variables?” (Jimura et al., 2021)

Statement of Retraction: London, R. E. and Slagter, H. A. Effects of Transcranial Direct Current Stimulation over Left Dorsolateral pFC on the Attentional Blink Depend on Individual Baseline Performance.

By the request of the authors, the following research article will be retracted from the Journal of Cognitive Neuroscience:London, R. E., & Slagter, H. A. (2015). “Effects of transcranial direct current stimulation over left dorsolateral pFC on the attentional blink depend on individual baseline performance” published in the Journal of Cognitive Neuroscience, 27(12), 2382–2393. https://doi.org/10.1162/jocn_a_00867While attempting to replicate and extend the original work, an error was discovered in the routine that implemented the analysis used to assess whether the relationship between an independent variable and a dependent variable is driven by regression to the mean (Mrytek & Foerster, 1986). After the error was corrected and the analysis was rerun, it was found that one of the main results—an influence of baseline level of performance on anodal tDCS-induced change in the attentional blink, presented in Figure 3—no longer held. Given that this finding was also expressed in the title of the article, the authors requested the article to be retracted. The complete set of results from this study, now with the corrected analysis, will be published as London R. E., & Slagter, H. A. “No effect of transcranial direct current stimulation over left dorsolateral prefrontal cortex on temporal attention” in the Journal of Cognitive Neuroscience, https://doi.org/10.1162/jocn_a_01679.

Right lateralized alpha desynchronization increases with the proportion of symmetry in the stimulus.

Research into the neural basis of symmetry perception has intensified in the last two decades; however, the functional role of neural oscillations remains unclear. In previous work Makin et al. (2014, Journal of Vision, 14, 1-12) and Wright et al. (2015, Psychophysiology, 52, 638-647) examined occipital alpha event-related desynchronization (alpha ERD). It was concluded that alpha ERD is right lateralized during active regularity discrimination but not during a secondary task. Furthermore, alpha ERD was unaffected by stimulus properties, such as the type of regularity. These conclusions are refuted by new time-frequency analysis on an electroencephalography (EEG) data set first introduced by Makin et al. (2020, Journal of Cognitive Neuroscience, 32, 353-366). We compared alpha ERD across five tasks. First, we found that right lateralization of alpha ERD was evident in all tasks, not just active regularity discrimination. This was caused by hemispheric differences in alpha power during prestimulus baseline (left<right), which equalized after stimulus onset (left=right). Second, we found that Alpha ERD increased with the proportion of symmetric elements in the image (PSYMM). Sensitivity to PSYMM was stronger on the right. These findings suggest that known extrastriate symmetry activations are accompanied by reduced alpha power.

Shifting Attention in Feature Space: Fast Facilitation of the To-Be-Attended Feature Is Followed by Slow Inhibition of the To-Be-Ignored Feature.

In an explorative study, we investigated the time course of attentional selection shifts in feature-based attention in early visual cortex by means of steady-state visual evoked potentials (SSVEPs). To this end, we presented four flickering random dot kinematograms with red/blue, horizontal/vertical bars, respectively. Given the oscillatory nature of SSVEPs, we were able to investigate neural temporal dynamics of facilitation and inhibition/suppression when participants shifted attention either within (i.e., color to color) or between feature dimensions (i.e., color to orientation). Extending a previous study of our laboratory [Müller, M. M., Trautmann, M., & Keitel, C. Early visual cortex dynamics during top-down modulated shifts of feature-selective attention. Journal of Cognitive Neuroscience, 28, 643-655, 2016] to a full factorial design, we replicated a critical finding of our previous study: Facilitation of color was quickest, regardless of the origin of the shift (from color or orientation). Furthermore, facilitation of the newly to-be-attended and inhibition/suppression of the then to-be-ignored feature is not a time-invariant process that occurs instantaneously, but a biphasic one with longer time delays between the two processes. Interestingly, inhibition/suppression of the to-be-ignored feature after the shifting cue had a much longer latency with between- compared to within-dimensional shifts (by about 130-150 msec). The exploratory nature of our study is reasoned by two limiting factors: (a) Identical to our precursor study, we found no attentional SSVEP amplitude time course modulation for orientation, and (b) the signal-to-noise ratio for single trials was too poor to allow for reliable statistical testing of the latencies that were obtained with running t tests of averaged data.

An Important Step toward Understanding the Role of Body-based Cues on Human Spatial Memory for Large-Scale Environments

Moving our body through space is fundamental to human navigation; however, technical and physical limitations have hindered our ability to study the role of these body-based cues experimentally. We recently designed an experiment using novel immersive virtual-reality technology, which allowed us to tightly control the availability of body-based cues to determine how these cues influence human spatial memory [Huffman, D. J., & Ekstrom, A. D. A modality-independent network underlies the retrieval of large-scale spatial environments in the human brain. Neuron, 104, 611-622, 2019]. Our analysis of behavior and fMRI data revealed a similar pattern of results across a range of body-based cues conditions, thus suggesting that participants likely relied primarily on vision to form and retrieve abstract, holistic representations of the large-scale environments in our experiment. We ended our paper by discussing a number of caveats and future directions for research on the role of body-based cues in human spatial memory. Here, we reiterate and expand on this discussion, and we use a commentary in this issue by A. Steel, C. E. Robertson, and J. S. Taube (Current promises and limitations of combined virtual reality and functional magnetic resonance imaging research in humans: A commentary on Huffman and Ekstrom (2019). Journal of Cognitive Neuroscience, 2020) as a helpful discussion point regarding some of the questions that we think will be the most interesting in the coming years. We highlight the exciting possibility of taking a more naturalistic approach to study the behavior, cognition, and neuroscience of navigation. Moreover, we share the hope that researchers who study navigation in humans and nonhuman animals will synergize to provide more rapid advancements in our understanding of cognition and the brain.

Gender (Im)balance in Citation Practices in Cognitive Neuroscience.

In the field of neuroscience, despite the fact that the proportion of peer-reviewed publications authored by women has increased in recent decades, the proportion of citations of women-led publications has not seen a commensurate increase: In five broad-scope journals, citations of papers first- and/or last-authored by women have been shown to be fewer than would be expected if gender was not a factor in citation decisions [Dworkin, J. D., Linn, K. A., Teich, E. G., Zurn, P., Shinohara, R. T., & Bassett, D. S. The extent and drivers of gender imbalance in neuroscience reference lists. Nature Neuroscience, 23, 918-926, 2020]. Given the important implications that such underrepresentation may have on the careers of women researchers, it is important to determine whether this same trend is true in subdisciplines of the field, where interventions might be more targeted. Here, we report the results of an extension of the analyses carried out by Dworkin et al. (2020) to citation patterns in the Journal of Cognitive Neuroscience. The results indicate that the underrepresentation of women-led publications in reference sections is also characteristic of papers published in Journal of Cognitive Neuroscience over the past decade. Furthermore, this pattern of citation imbalances is present regardless of author gender, implicating systemic factors. These results contribute to the growing body of evidence that intentional action is needed to address inequities in the way that we carry out and communicate our science.

Processing Speech and Thoughts during Silent Reading: Direct Reference Effects for Speech by Fictional Characters in Voice-Selective Auditory Cortex and a Theory-of-Mind Network.

Stories transport readers into vivid imaginative worlds, but understanding how readers create such worlds-populating them with characters, objects, and events-presents serious challenges across disciplines. Auditory imagery is thought to play a prominent role in this process, especially when representing characters' voices. Previous research has shown that direct reference to speech in stories (e.g., He said, "I'm over here") may prompt spontaneous activation of voice-selective auditory cortex more than indirect speech [Yao, B., Belin, P., & Scheepers, C. Silent reading of direct versus indirect speech activates voice-selective areas in the auditory cortex. Journal of Cognitive Neuroscience, 23, 3146-3152, 2011]. However, it is unclear whether this effect reflects differential processing of speech or differences in linguistic content, source memory, or grammar. One way to test this is to compare direct reference effects for characters speaking and thinking in a story. Here, we present a multidisciplinary fMRI study of 21 readers' responses to characters' speech and thoughts during silent reading of short fictional stories. Activations relating to direct and indirect references were compared for both speaking and thinking. Eye-tracking and independent localizer tasks (auditory cortex and theory of mind [ToM]) established ROIs in which responses to stories could be tracked for individuals. Evidence of elevated auditory cortex responses to direct speech over indirect speech was observed, replicating previously reported effects; no reference effect was observed for thoughts. Moreover, a direct reference effect specific to speech was also evident in regions previously associated with inferring intentions from communication. Implications are discussed for the spontaneous representation of fictional characters and the potential roles of inner speech and ToM in this process.