Pulse-activated transitions from the metastable to the running state and vice versa have been observed in a stacked double tunnel Nb-based Josephson system. Experimental results are compared with numerical simulations based on the Sine–Gordon model of the stacked junctions by injecting pulses with variable amplitude in one of the junctions of the stack, and observing the voltage response of the other junction. Both experimental and numerical results show the possibility to induce both direct and back-switching transitions from the metastable to the running state simply by changing the amplitude of the electronic pulses injected across the stack device.