Josep Trueta Research Articles

Antineutrophil cytoplasmic antibodies (pANCA) in sera from colectomized ulcerative colitis (UC) patients: [formula omitted], J Mallolas, J Klaassen, A Abad-Lacruz, F González-Huix, E Cabré, F Fernández-Bañares, X Bertrán, E Condon, J Marti-Ragué, MA Gassull. Hosp. “Germans Trias i Pujol”, Hosp. “Josep Trueta”, Hosp. “Sant LLorenç”, Hosp. “Princeps d'Espanya”, Catalonia, Spain

Antineutrophil cytoplasmic antibodies (pANCA) in sera from colectomized ulcerative colitis (UC) patients: [formula omitted], J Mallolas, J Klaassen, A Abad-Lacruz, F González-Huix, E Cabré, F Fernández-Bañares, X Bertrán, E Condon, J Marti-Ragué, MA Gassull. Hosp. “Germans Trias i Pujol”, Hosp. “Josep Trueta”, Hosp. “Sant LLorenç”, Hosp. “Princeps d'Espanya”, Catalonia, Spain

Solid neuroendocrine breast carcinomas: Incidence, clinico-pathological features and immunohistochemical profiling

Primary pure neuroendocrine breast carcinomas (NEBC) have been considered special features within conventional breast carcinomas until recently. Indeed, the actual incidence of NEBC in BC populations has remained largely unknown due to the lack of unambiguous diagnostic criteria. In 2003, the World Health Organization (WHO) classification of breast tumors definitely established that the immunohistochemical expression of NE markers in more than 50% of the tumor cell population is the unique requisite for NEBC diagnosis. Herein, we sought to determine the incidence, the clinico-pathological features and the immunohistochemical profile of NEBC in a large series of 1368 infiltrating breast tumors collected from 1989 to 2008 in our institution (Dr Josep Trueta University Hospital, Girona, Catalonia). Twelve cases were initially selected to fulfil histopathological patterns compatible with NEBC. Clinical data along with histological and immunohistochemical profiles were collected in all cases. The criterion inclusion was the presence of more than 50% tumor immunoreactivity for one of NE markers including chromogranin, synaptophysin and CD56. Only 7 tumors fully satisfied the NEBC criteria established by the WHO (0.5% prevalence). All the NECB were grade 2 ductal carcinoma infiltrating (DCI) with tumor sizes ranging from 7 to 55 mm. Lymphovascular tumoral emboli was present in 4 cases (57.1% of NEBC) and mucinous features occurred in 2 cases (28.5% of NEBC). Axillary lymph nodes were metastatic in 3 cases (42.8% of NEBC). A positive status for estrogen receptor (ER), progesterone receptor (PR) and synaptophysin was observed in 7 cases (100% of NEBC). None of the NEBC displayed HER2 overexpression. All the patients bearing NECB received hormone therapy and 4 of them underwent radiotherapy and/or chemotherapy. Of note, none of the NEBC patients died from BC-related causes after a median follow-up of 51 months. These findings revealed that: a) Pure solid NEBC do not significantly differ from other breast carcinomas in terms of general clinical features; b) NEBC do not exhibit an aggressive behavior despite the presence of adverse prognostic factors; and c) NEBC immunohistochemical profile mainly corresponds to that of the Luminal A BC subtype. Although it remains to be elucidated whether the good prognosis of NEBC relates to the intrinsic nature of the tumor and/or to a high rate of treatment responses, their immunohistochemical profile strongly suggest that NEBC belong to the Luminal A BC subtype. Forthcoming studies should definitely determine if the clinico-pathological features of NEBC indeed represent an independent good-prognosis subgroup of BC gene signature.

Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis F GONZALEZ‐HUIX, R FERNANDEZ‐BANARES, M. ESTEVE‐COMAS, ET AL Hospital “Josep Trueta,” Girona, Catalunya, Hospital Universitari “Germans Trias i Pujol,” Badalona, Catalyna, Spain

Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis F GONZALEZ‐HUIX, R FERNANDEZ‐BANARES, M. ESTEVE‐COMAS, ET AL Hospital “Josep Trueta,” Girona, Catalunya, Hospital Universitari “Germans Trias i Pujol,” Badalona, Catalyna, Spain

Josep Trueta, Trueta: surgeon in war and peace, translated by Amelia and Michael Stubell, London, Gollancz, 1980, 8vo, pp. 288, £9.95.

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REVIEWS OF BOOKS

British Journal of UrologyVolume 19, Issue 3 p. 178-179 REVIEWS OF BOOKS First published: September 1947 https://doi.org/10.1111/j.1464-410X.1947.tb10645.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Books reviewed in this article: Urology in General Practice. By N. F. Ockerblad Studies of the Renal Circulation. By Josep Trueta, M.D. Volume19, Issue3September 1947Pages 178-179 RelatedInformation