Joint Structure Research Articles

Influence of tempering on structure and properties of welded joints of high-strength structural steel achieved by submerged arc welding

The paper describes mechanical properties and microstructure of weld metal of welded joints of high-strength structural steel AB3K made by automatic submerged arc welding with K-shaped edge cutting. The comparative analysis of the process using Sv-07KhN3MD wire and 48A3 flux subjected to heat treatment under four different modes is carried out.

Therapeutic potential of d-limonene in rheumatoid arthritis: Modulation of inflammatory, anti-inflammatory cytokines, and prostaglandin E2.

Rheumatoid arthritis (RA) is a persistent autoimmune disorder predominantly affecting the joint structures, eliciting inflammatory responses, and ultimately leading to degenerative changes without proper medical intervention. Ultimately, this can severely impair joint function and impact the patient's quality of life. Current treatment approaches include disease-modifying anti-rheumatic drugs, non-steroidal anti-inflammatory drug, corticosteroids, and biologic therapies for RA management. The current study contributes to the ongoing advancements in RA treatment. d-Limonene is a monocyclic monoterpene. It is present in essential oils of various aromatic plants, such as Lippia alba and Artemisia dracunculus, and in citrus fruits such as lemon and orange. It has reported anti-inflammatory and anti-nociceptive properties and was selected for the current study as a potential anti-arthritic candidate. It was administered at three dosages (25, 50, 100 mg/kg, b.w., p.o) in Complete Freund's adjuvant-induced arthritic rats over 28 days. The efficacy of the compound was compared to piroxicam, a widely used standard drug for treating RA. The anti-arthritic activity of the compound was assessed by measuring arthritic scoring and plethysmometry at both baseline and post-intervention stages. Additional confirmation of the investigation was sought by performing biochemical and hematological activities. Moreover, quantitative polymerase chain reaction was employed to determine the levels of messenger RNA expression for transcription factors such as tumor necrosis factor-α, interleukin (IL)-1β, nuclear factor-κB, matrix metalloproteinase-3, IL-6, and IL-4 in the blood. The levels of PGE2 were evaluated by enzyme-linked immunosorbent assay. The histopathological and radiographic studies were also carried out for further confirmation. The results of these findings supported our assertion regarding the anti-arthritic potential of the compound.

Numerical analyses of the influences of rock properties and joints on rock fragmentation in shaft sinking by drilling method

The mechanical rock-crushing efficiency is directly influenced by rock properties and joint structure. Tipped-hob is widely used in the construction of shafts. By analyzing the motion of tipped-hob and the mechanical properties of granite and sandstone, numerical rock samples with different mechanical properties were built to investigate the influences of rock properties and joint structure on rock-crushing efficiency using a single ring of tipped cutter. The results revealed correlations between compressive strength, tensile strength, hardness, brittleness, specific energy consumption, and the vibration of thrusting forces. It was suggested that the spacing, dip angle, and continuity of joints have a significant impact on the failure patterns and crack propagation in the process of rock fragmentation, as well as on the vibration frequency and amplitude of breaking-force of cutter and the specific energy consumption. This research is crucial for controlling the stability of drilling machine during shaft sinking by drilling method.

Atomistic insights into cold welding process of high-entropy alloy nanowires

This research applied molecular dynamics (MD) simulations to investigate the influences of contact pressure, temperature, crystal orientation, and chemical composition on the characteristics of the cold welding joints of CoNiCrFeMn high-entropy alloy (HEA) nanowires. The findings indicate that defect-free cold welded joints can be successfully formed within a contact pressure range of 10 to 10,000 Pa. In addition, changing the contact orientation could cause a significant change in the structure transformation level. The dislocation distribution is continuous when the top and lower blocks are oriented in the same direction. Dislocation lines, on the other hand, stop at the interfacial area and have a discontinuous shape when the weld joints are formed from different orientations. Furthermore, creating from the same orientations leads to a higher ultimate tensile strength (UTS) value than the different orientation cases. In the temperature range of 150 K–350 K, the deformation behaviors of the cold weld joint are stable. Besides, there was no noticeable change in the weld joint when the composition changed. Because of the strong crystal structure of the cold welding joints, the UTS values of the cold-welded joints range from 13.2 to 17.4 GPa, comparable to the bulk samples.

A Closure Contact Model of Self-Affine Rough Surfaces Considering Small-, Meso-, and Large-Scale Stage Without Adhesive

Contact interface is essential for the dynamic response of the bolted structures. To accurately predict the dynamic characteristics of bolted joint structures, a fractal extension of the segmented scale model, i.e., the JK model, is proposed in this paper to comprehensively analyze the dynamic contact performance of engineering surfaces and revisit the multi-scale model based on the concept of asperities. The influence of asperity geometry, dimensionless material properties, and the elastic, elastoplastic, and full plastic mechanical models of a single asperity is established considering the asperity–substrate interaction. Then, a segmented scale contact model of rough surfaces is proposed based on the island distribution function in a strict sense. The mechanical contact process of determining rough surfaces is divided into small-scale, medium-scale, and large-scale stages. Moreover, cross-scale boundary conditions, i.e., al1′, al2′, and al3′, are provided through strict mathematical deduction. The results show that the real contact area and contact stiffness are positively correlated with fractal dimension and negatively correlated with fractal roughness. On a small scale, the contact damping decreases with an increase in load. In meso-scale and large-scale stages, the contact damping increases with the load. Finally, the reliability of the proposed model is verified by setting up three groups of modal vibration experiments.

3D-printed modular platform for path-customizable liquids transport

Spontaneous liquid transport is increasingly being applied in various fields such as microfluidics, fuel cells, phase change heat transfer, water harvesting, etc. However, long-distance spontaneous liquid transport with path-customizable motion trajectories is still challenging. Drawing multi-inspirations from the wedge-shaped structures of iris petals, the continuous structures of bamboo joints, and the microgroove structures of Nepenthes mouth edge, we fabricate a modular, pump-free biomimetic liquid transport platform by 3D printing and surface modification. The platform is composed of sequential wedge notches, and a crescent-shaped groove is designed at the joint of every two connected wedge structures. The platform is characterized by path-customizable liquid transport trajectories and can be used to achieve long-distance liquid transport without the need of external energy fields, and the multi-level nested structures along the depth significantly facilitates the liquid transport. Experimental study and theoretical force analysis show that the crescent-shaped grooves enable the liquid to overcome joint barriers by converting potential energy accumulated at joints into kinetic energy, achieving a maximum velocity of 18 mm/s. Taking advantage of the flexibility of 3D printing and long-distance transport capability, the modular structure of the platform enables customization of the transport distance and trajectory. By assembling 14 bamboo-like wedge-shaped units in series, we realized a transport distance up to 350 mm, which could be further increased by connecting more units. Furthermore, we develop various modular and multifunctional liquid transport platforms for anti-gravity transport, liquid diversion, and customized transport trajectories, which demonstrate that our design strategy could be an available solution for path-customizable liquids transport in fields like bio-sensing, fuel cells, etc.

Targeting Synovial Macrophages with Astaxanthin-Loaded Liposomes for Antioxidant Treatment of Osteoarthritis.

Osteoarthritis (OA) is a chronic joint disease highly associated with an imbalance in the network of inflammatory factors and typically characterized by oxidative stress and cartilage damage. Moreover, the specificity of the joint structure makes it difficult for drugs to achieve good penetration and effective enrichment in the joint cavity. Therefore, therapeutic strategies that increase the specific targeting of drugs to inflammatory joint and incorporate antioxidative stress effects are important to improve the efficacy of OA. Here, we developed a folic acid-modified liposomal nanoparticle (AST@Lip-FA) loaded with the antioxidant astaxanthin (AST) to enhance the water solubility and stability of AST and to target the delivery of AST to the site of OA, leading to a significant improvement in therapeutic efficacy. In vitro experiments demonstrated that, due to the recognition by FA of the receptor folate receptor β on the surface of activated macrophages, the cellular uptake efficiency of AST@Lip-FA was increased. Meanwhile, intracellularly overexpressed inflammatory mediators such as reactive oxygen species and nitric oxide were efficiently removed by AST@Lip-FA. In addition, in the ACLT-induced OA mouse model, AST@Lip-FA was precisely enriched in the inflamed joints and achieved long-term retention, fully utilizing the anti-inflammatory, antioxidant, and cartilage-protecting effects of AST to effectively alleviate the progression of OA. In summary, AST@Lip-FA has an important prospect as a potential and effective therapeutic strategy for OA.

Fatigue life assessment and verification of turbine joints: current status and prospects

The research status of fatigue life assessment technology for turbine joint structures is introduced. The progress, shortcomings and development trends of existing research are discussed from the aspects of multi-field load analysis, crack initiation life assessment, crack propagation simulation and test technology. The evaluation methods of service life and damage tolerance of turbine joint structures are discussed in detail. The results show that the existing analysis and test methods can basically realize the fatigue life assessment of turbine joints, but due to various limitations, the engineering applicability needs to be improved urgently. Robust load reduction analysis methods, life assessment methods based on physical mechanisms and data-driven, load history-related crack propagation life assessment methods and test technologies under complex thermal environments are still needed to establish a fatigue life assessment and verification system for advanced aero-engine turbine joint structures.

Seismic Behavior of Concrete Beam-Column Joints Reinforced with Steel-Jacketed Grouting

Joints in frame structures often fail before beams and columns in an earthquake and are a key part of reinforcement. In this study, to enhance the seismic performance of concrete frame structures, a steel-jacketed grouting composite reinforcement method is proposed by combining reinforcement technology, steel cladding technology, and eco-efficient materials from grouting technology. This method effectively utilizes the advantages of various materials, avoids major demolition and construction, and reduces waste and resource consumption. In order to verify the feasibility and effectiveness of the reinforcement method, one of the original joint specimens with a scale of 1:3 and one of the reinforced joint specimens were designed and tested. The experiments involved reversed cyclic testing of beam–column to measure its seismic behavior. The seismic performance indexes such as failure characteristics, hysteretic properties, and the energy dissipation capacity of the specimens were analyzed, and the corresponding finite element model was established. The influence of key parameters such as reinforcement range, steel plate thickness, and grout strength on its seismic performance was explored. The research shows that the method can effectively improve the seismic performance of the joints, and seismic performance indexes such as bearing capacity, ductility, and energy consumption of the specimens are significantly improved. The test results of the established finite element model are in good agreement. The variable parameter analysis of the finite element shows that the thickness of the steel plate has little influence on its bearing capacity. With the increase in the reinforcement range of the clad steel and the strength of the grouting material, the bearing capacity of the specimen increases. The research results can provide a reference for the reinforcement of frame structure joints.

Aircraft joint structure lightweight design

PurposeThe purpose of this article is to carry out a lightweight design of the joint structure according to the service condition of the joint.Design/methodology/approachThe finite element analysis techniques are used along with the variable density structure topology optimization method, the multi-island genetic algorithm for structural dimension optimization and the fatigue life analysis method.FindingsUtilizing the topology optimization method and size optimization method, the mass of the optimized model for the A100 material model is 9.67 kg. Compared to the pre-optimized model, the mass decreases by 8.23 kg, representing a weight reduction of 46.0% in the optimized model; the fatigue life of the aircraft joint is predicted to be a maximum of 1,460,017 cycles.Originality/valueThe originality of this study is that it provides new design ideas for the lightweight design of aircraft load-bearing structures.

Offset-stoichiometric reflowable composite bonding method with adhesive for mitigating strict faying surface tolerances

Inherent susceptibility of adhesive bonds to miniscule quantities of contamination can cause undetectable weakened bonds. For this reason, the Federal Aviation Administration (FAA) places strict regulations on adhesively bonded joints in primary aircraft structures. To meet certification requirements aircraft manufactures resort to redundant load paths in the form of fasteners which inherently add weight to the structure and increase manufacturing time. In prior work, a secondary bonding technique called AERoBOND was developed, which utilized off-stoichiometric epoxy-matrix resins to facilitate reflow and diffusion of the resin within the joint interface during a secondary bonding/cure process, thus achieving a bond similar to a co-cured joint. However, the AERoBOND process required tight spatial tolerances between the two parts being joined. This study examined the utilization of conventional adhesive with the AERoBOND method to act as a filler in the joint line, effectively reducing the need for tight tolerances on the joining parts and serving as a flexible alternative for existing manufacturing processes. Ultrasonic inspection, optical microscopy, and ASTM International standard tests were performed to analyze the joints for defects and to quantify the mode-I and mode-II interlaminar fracture toughness and short beam strength of the proposed methodology with varying manufacturing parameters. The comprehensive results indicate that the AERoBOND+ method with and without surface preparation performs comparably to co-cured and conventional, adhesively bonded joints when secondary cured in an autoclave with 791 kPa of pressure. As an example, the AERoBOND+ panel without surface preparation bonded with 791 kPa of pressure (referred to as AB+3 throughout paper) had a mode-I fracture toughness (GIc) of 0.643 kJ/m2 and a mode-II fracture toughness (GIIc) of 4.000 kJ/m2 in the non-precracked condition and 4.218 kJ/m2 in the precracked condition at the adhesive-to-prepreg interface. These results were 96 %, 142 %, and 217 %, respectively, of a co-cured baseline panel (referred to as C1 throughout paper).

Void detection in structural adhesive joints using a k-Nearest Neighbors model with features from Electromechanical Impedance Spectroscopy

Electromechanical Impedance Spectroscopy (EMIS) is a promising Structural Health Monitoring (SHM) method which allows the early detection of defects by analyzing the structure response to an AC electrical signal swept through a range of high frequencies. In this work, EMIS measurements of pristine and damaged adhesive joints were performed, and features were extracted from the experimental measurements. These features were inputted to a k-Nearest Neighbors (kNN) model for damage detection. Results show that only one type of features is enough for damage detection. Furthermore, the use of the Manhattan Distance in the kNN enables a better classification.

Methotrexate promotes the release of granulocyte–macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling

BackgroundActivated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use of disease-modifying drugs, only about 50% of RA patients reach remission in real-world settings. We used an unbiased approach to investigate the effects of standard-of-care methotrexate (MTX) and a Janus kinase inhibitor, tofacitinib (TOFA), on gene expression in RA-FLS, in order to identify untargeted disease mediators.MethodsPrimary RA-FLS were activated by stimulation with interleukin-1β (IL-1β) or platelet-derived growth factor + IL-1β in the presence or absence of MTX or TOFA, with or without additional inhibitors. Co-cultures of synovial cells were performed in direct and indirect systems. Cells were collected for RNA sequencing or qPCR, and supernatants were analyzed for protein concentrations.ResultsSix thousand three hundred fifty genes were differentially expressed, the majority being upregulated, in MTX-treated activated RA-FLS and 970 genes, the majority being downregulated, in TOFA-treated samples. Pathway analysis showed that MTX had largest effects on ‘Molecular mechanisms of cancer’ and TOFA on ‘Interferon signaling’. Targeted analysis of disease-associated genes revealed that MTX increased the expression of cell cycle-regulating genes but also of pro-inflammatory mediators like IL-1α (IL1A) and granulocyte–macrophage colony-stimulating factor, GM-CSF (CSF2). The MTX-promoted expression of CSF2 in activated RA-FLS peaked at 48 h, could be mediated via either NF-κB or AP-1 transcription factors, and was abrogated by IL-1 inhibitors (IRAK4 inhibitor and anakinra). In a co-culture setting, MTX-treatment of activated RA-FLS induced IL1B expression in macrophages.ConclusionsMTX treatment induces secretion of IL-1 from activated RA-FLS which by autocrine signaling augments their release of GM-CSF. This unexpected effect of MTX might contribute to the persistence of synovitis.

Advances in diagnosing osteoarthritis: clinical applications of musculoskeletal ultrasonography

Background: Osteoarthritis (OA) is the most common arthritis globally. Besides cartilage loss, all surrounding structures of the joint, including the synovium, capsule, ligament, bone, nerve, and muscle, are affected by this disease, resulting in joint failure. The traditional diagnosis of OA depends on clinical symptoms, physical examination, and radiographic findings. Ultrasonography (US), computed tomography, and magnetic resonance imaging (MRI) are imaging modalities commonly used for assessing OA.Current Concepts: US findings of OA indicate synovitis, hyaline and fibrous cartilage damage, ligament and tendon changes, and bony abnormalities. US is clinically useful because it correlates with the clinical pain index and radiographic and MRI findings, differentiates the various causes of OA pain, helps diagnose early disease, predicts prognosis, and increases the accuracy and safety of intra-articular injections in OA joints.Discussion and Conclusion: Although US has some limitations as a tool for examining whole joint structures, its use is predicted to increase in the future because it is beneficial and easily accessible for assessing OA. To produce accurate US results, the examiner should have deep anatomical knowledge and skilled practice techniques, and a clinical diagnosis should be performed based on clinical symptoms and physical examination.

Thermal cycles, structure and properties of welded joints in structural steels during welding in extreme cold conditions

The article summarizes research on the thermal cycles, structure, and properties of welded joints made from low-alloy and low-carbon steels during arc welding in sub-zero temperatures. This review aims to analyze previous research to create solid recommendations for welding steel bridge structures during winter conditions. The results of a comparison of experimental measurements of thermal cycles of welding samples with different sizes made at room and subzero ambient air temperatures (down to minus 50 °C) are considered. It is shown that in small plates with dimensions of 200 × 250 × 10 mm, due to more intense heat reflection from the edges of the specimen, the thermal cycles of welding at different temperatures do not differ significantly. In more massive samples (sized 450 × 250 × 10 mm), an increase in the cooling rate of the overheated welded joint area is observed compared to room temperature welding. The impact of hydrogen on the development of cold cracks in low-alloy steels during welding at temperatures below freezing is examined. Metallographic analysis has revealed that the structural changes that occur during the welding of various steel grades are notably different and are influenced by the steel’s chemical composition as well as the thermal cycle parameters of the welding process. Dilatometric studies indicate that variations in the levels of alloying elements within different grades significantly influence the kinetics of austenite transformation. Therefore, to identify the best welding techniques for subzero temperatures, it is essential to consider not just how heat disperses in these conditions, but also the kinetics of phase changes and their effects on the structure and properties of the products resulting from austenite decomposition.

Bionic Design of High-Performance Joints: Differences in Failure Mechanisms Caused by the Different Structures of Beetle Femur-Tibial Joints.

Beetle femur-tibial joints can bear large loads, and the joint structure plays a crucial role. Differences in living habits will lead to differences in femur-tibial joint structure, resulting in different mechanical properties. Here, we determined the structural characteristics of the femur-tibial joints of three species of beetles with different living habits. The tibia of Scarabaeidae Protaetia brevitarsis and Cetoniidae Torynorrhina fulvopilosa slide through cashew-shaped bumps on both sides of the femur in a guide rail consisting of a ring and a cone bump. The femur-tibial joint of Buprestidae Chrysodema radians is composed of a conical convex tibia and a circular concave femur. A bionic structure design was developed out based on the characteristics of the structure of the femur-tibial joints. Differences in the failure of different joint models were obtained through experiments and finite element analysis. The experimental results show that although the spherical connection model can bear low loads, it can maintain partial integrity of the structure and avoid complete failure. The cuboid connection model shows a higher load-bearing capacity, but its failure mode is irreversible deformation. As key parts of rotatable mechanisms, the bionic models have the potential for wide application in the high-load engineering field.

Recent Insights and Clinical Status on Novel Mefenamic Acid Nanocarriers for the Treatment of Rheumatoid Arthritis

Abstract: Joint structure and performance can be compromised by the systemic inflammatory disorder rheumatoid arthritis, which destroys articular cartilage and erodes periarticular bone. However, due to their systemic processes, short half-lives, and poor bioavailability, the anti-inflammatory medicines and biological agents now utilized for the treatment of rheumatoid arthritis (RA) are unable to preferentially target inflamed joints. Anti-inflammatory medicines have made use of nanoparticle-mediated drug delivery methods. The role that inflammation plays in the genesis of disease has had far-reaching repercussions, including its ability to influence the development of disorders as diverse as inflammatory bowel disorder, RA, and osteoarthritis. In the treatment of RA, nanomaterials have the potential to both increase the absorption of the medication and selectively target the damaged joint tissue. Designer nanoparticles now have the ability to engage more thoroughly with their biological targets and a wider variety of diseases. These nanoparticles have a comparable size range and surface properties that can be modified. In this review, we have discussed the progress that has been made and the hurdles that remain in the use of nanomaterials in the treatment of RA, specifically in relation to mefenamic acid.

Corrosion behavior of dissimilar Al–Mg–Si alloys joint welded under hybrid CMT-laser oscillation welding

As the corrosion behavior of 6xxx series aluminum alloys depends on composition and microstructure, the microstructure and corrosion behavior of 6082 and a new 6xxx aluminum alloy weld joint are investigated under a standard corrosion test in this study. These results show the asymmetrical welding joint structure and a distribution of corrosion severity across the weld joint. Substantial differences were observed in the size and distribution of Mg2Si particles and Fe-bearing intermetallics in various regions of the weld joint. It was found that the equiaxed grain zone on new 6xxx aluminum side is not most susceptible to corrosion, contrary to previous results, but the narrow partially melted line on 6082 side is. Not all corrosion induced by Fe-bearing intermetallics originates from the Al matrix, adjacent Fe-bearing intermetallics and Mg2Si could also form galvanic microcells, resulting in preferential dissolution of Mg2Si over the Al matrix.

Experimental and numerical investigation of a novel passive energy dissipation system with viscoelastic damper and angle-reaction controller

Sharp and significant changes in the relative angle between beam and column during earthquakes often lead to failure of structural joints. This study proposed a novel passive Energy Dissipation system (PEDs) consisting of a viscoelastic damper (VED) and an angle-reaction controller (ARC). The ARC provides mutual support to the joint by establishing temporary supports in reinforced concrete or steel frames to allow for free-angle multilevel control in the case of excessive relative angle. This feature distinguishes the novel PEDs from previous systems as it allows the reaction force of the temporary support to compensate for the loss of joint rotational stiffness. The cyclic loading tests were conducted by constructing fundamental components, and then a mechanical model for the novel PEDs was established. Numerical simulations were performed to analyze parameter variations and to provide a comprehensive methodology for evaluating the seismic performance of the novel PEDs. The results demonstrated that two mechanisms were effectively incorporated into the novel PEDs: vibration energy dissipation and protection against excessive angles. The multistage flag hysteresis curve confirmed the reliability of our theoretical model in representing this novel PEDs. Therefore, supplementing rotational stiffness while achieving energy dissipation can be considered a new approach for enhancing seismic performance in frame structures.

Impact of Stabilization Splint Therapy on Orthodontic Diagnosis in Patients with Signs and Symptoms of Temporomandibular Disorder.

The relation between the orthopedic temporomandibular joint (TMJ) instability and temporomandibular disorder (TMD) most commonly remain unrecognized by orthodontists. In this study we aimed to evaluate the dentofacial characteristics and temporomandibular disorder symptomatology of patients with orthopedic instability before and after deprogramming with a stabilization splint. Sixty patients with the signs and symptoms of TMD were assessed using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and underwent stabilization splint therapy to place the condyles in a more stable musculoskeletal position. The extent of condylar displacement was evaluated using the condylar position indicator (CPI). Sixteen angular and linear hard tissue landmarks were traced and compared from lateral cephalograms taken in the maximum intercuspation (MI) position before, and in the centric relation (CR) position after, the splint therapy. Following the splint therapy, the signs and symptoms of TMD were significantly reduced or completely eliminated in more than 90% of patients. Compared with the values registered before the splint therapy, a significant reduction in the mean values of condylar displacement was observed on both sides of the vertical (p < 0.001), horizontal (p < 0.05), and transverse (p < 0.001) planes of space after the splint therapy. A comparison of pre- and post-splint lateral cephalograms revealed that, following the splint therapy, the mandible moved more posteriorly and rotated in a more clockwise direction. In patients with orthopedic instability and the signs and symptoms of TMD, muscle deprogramming with a stabilization splint therapy is highly recommended to improve the health of the temporomandibular joint and masticatory structures and contribute to a more correct orthodontic diagnosis.