Joint Preservation Research Articles

Corrective Distal Tibio-Fibular Osteotomy for Medial Ankle Osteoarthritis: Consecutive 67 Cases, Prognostic Factors and 3B Cases Outcomes Evaluation

Category: Ankle Arthritis; Ankle Introduction/Purpose: Supramalleolar osteotomy is a considerable technique for medial compartment ankle arthritis as a joint preservation and has been shown to be effective in several studies The indication for supramalleolar osteotomy is generally presented as early and mid-stage arthritis (Takakura stage 2 or 3A), and there is much arguments about the application of stage 3B. This study analyzes the results of suprmalleolar osteotomy performed in patients with Takakura stage 3B arthritis and seeks to identify factors that influence clinical outcomes. Methods: From August 2007 to May 2021, a total of 67 cases in which tibio-fibula osteotomy were performed for medial compartment arthritis of the ankle joint. We analyzed 67 cases and 19 cases of 3B stage before surgery which were possible for at least on year follow-up. Clinical assessments assessed VAS score, AOFAS score, and ROM, and radiological assessment assessed TAS angle, TLS angle, Talar tilt, and Contact surface percentage. Results: VAS pain scores improved from 6.6(3-9) to 2.3(0-6), AOFAS scores improved from 56.6(20-87) to 85.1(66-100), and ROM DF/PF improved from 15.3/30.6 to 16.7/34.6 degrees, which was not significantly different from the Takakura stage 2 or 3A group performed in this center at the same time. The preoperative and final follow-up TAS angle was 2.5 degrees overcorrection, from 84.7 to 97.2, and the TLS angle changed from 77.6 to 81.5. The talus tilt improved from 9.1 to 6.8 degrees, which was higher than in the Takakura stage 2 or 3A patient group. Except one case, All cases obtained bone union, with an average duration of 7.5 (3-12) months. And we found contact surface percentage help us anticipate possibility of correction and clinical outcomes. Conclusion: Compared to stage 2 or 3A, the results of supramalleolar osteotomy in Takakura stage 3B patients showed radiologically TAS overcorrection and higher talar tilt angles, but clinically there was no significant difference and showed good results. Therefore, it is believed that even in advanced medial compartment ankle arthritis at stage 3B, it may be a selectively good indication for supralleolar osteotomy.

Lower Limb Alignment in Patients with Primary Valgus Ankle Arthritis: A Comparative Analysis with Patients with Varus Ankle Arthritis and Controls

Category: Ankle Arthritis; Ankle Introduction/Purpose: A comprehensive analysis of lower limb alignment may be a critical component of successful ankle joint preservation surgery. Although it is widely recognized that the combined effect of lower limb orientation and ankle and hindfoot alignment plays a fundamental role in ankle arthritis, supramalleolar/lower limb alignment has received less attention in valgus ankle arthritis. This study aims to analyze the lower limb alignment of patients with valgus ankle arthritis with primary origin, compared to those with varus ankle arthritis and normal controls. We hypothesize that patients with valgus ankle arthritis will exhibit the opposite pattern of lower limb alignment to those with varus ankle arthritis: valgus mechanical axis, valgus distal tibial plafond, and valgus hindfoot alignment. Methods: A retrospective radiographic analysis was conducted on 61 patients (62 ankles, mean age: 59.2 years) with valgus ankle arthritis with primary origin was performed. Preoperative weightbearing radiographs were used to measure seven radiographic parameters: Talar tilt angle, medial distal tibial angle (MDTA), talar center migration (TCM), anterior distal tibial angle (ADTA), talo-first metatarsal (Meary’s) angle, hindfoot moment arm (HMA), and mechanical axis deviation (MAD). For comparative radiographic analysis, a varus arthritis group with primary origin (n=55, mean age: 59.7 years) and a control group (n=58, mean age: 29.3 years) were included. Subgroup analyses of lower limb alignment were performed in the valgus arthritis group based on the MDTA (greater or less than 90 degrees, subgroup analysis 1) and Meary's angle (greater or less than -20 degrees, subgroup analysis 2). Results: The valgus group had a significantly lower mean MDTA than the control group (p < 0.0001, Figure 1), indicating a varus distal tibial plafond in comparison to the control group. Meary's angle and HMA were significantly lower in the valgus group compared to the varus group (p < 0.05 and p< 0.0001, respectively). On whole limb radiographs, the valgus group showed a greater MAD than the control group (p < 0.05), indicating a varus lower limb alignment. However, there was no significant difference in MAD between the valgus and varus groups (p=0.7031). Subgroup analysis 1 revealed that the MAD was varus- angulated regardless of the MDTA. Subgroup analysis 2 showed that both groups had comparable MDTA (p=0.8504); however, patients with a lower Meary’s angle had a significantly greater MAD. Conclusion: Our findings indicate that a significant proportion of ankles with primary valgus arthritis have a varus tibial plafond and a varus lower limb mechanical axis, which contradicts our current understanding. The similar lower limb and distal tibia orientation and different foot and hindfoot alignment between the valgus and varus group suggest that foot and hindfoot alignment may play an important role in the development of both types of arthritis. This study adds to our understanding of primary valgus ankle arthritis and suggests that lower limb alignment should be analyzed and considered throughout valgus ankle arthritis realignment procedures.

Saving Stabilizing Structure Treatment With Bilateral-Contralateral Decompression for Spinal Stenosis in Degenerative Spondylolisthesis Using Unilateral Biportal Endoscopy.

This study aimed to evaluate the treatment of spinal stenosis with spondylolisthesis using bilateral-contralateral unilateral biportal endoscopic (UBE) decompression to minimize facet joint damage. We retrospectively evaluated 42 patients with grade 1 spondylolisthesis who underwent bilateral-contralateral UBE decompression between July 2018 and September 2019. To identify segmental instability, static and dynamic images from preoperative and postoperative procedures and final follow-up radiographs were reviewed. Lateral radiograph slippage ratio, sagittal motion, and facet joint preservation were evaluated. Clinical assessments were conducted using the visual analogue scale (VAS), Oswestry Disability Index (ODI), and modified MacNab criteria. The average final follow-up period was 26.5 ± 1.3 months. The average preoperative slip percentage was 15.70% ± 5.25%, which worsened to 18.80% ± 5.41% at the final follow-up (p < 0.005). The facet joint preservation rate was 95.6% ± 4.1% on the contralateral side. Improvements in the VAS scores (leg pain: from 7.9 ± 2.2 to 3.1 ± 0.7; p < 0.005; back pain: from 7.2 ± 3.0 to 2.8 ± 1.0; p < 0.005) were observed at the final follow-up. The mean preoperative ODI was 26.19 ± 3.42, which improved to 9.6 ± 1.0 (p < 0.005). Thirteen patients exhibited delayed focal segmental instability following decompression. Despite the absence of symptoms or improvement with conservative treatment in the majority of patients with delayed instability, two patients required fusion surgery to address the instability. Additionally, 2 patients developed facet synovial cysts, while 2 experienced spinous process fractures. Bilateral decompression with a contralateral UBE approach could be an effective and alternative treatment method to reduce instability in spinal stenosis with grade 1 spondylolisthesis.

Periacetabular Osteotomy with a Modified Fixation Technique Using K-Wires Shows Clinical Results Comparable to Screw Fixation at Mid-Term Follow-Up.

The optimal fixation technique in periacetabular osteotomy (PAO) remains controversial. Modified fixation with Kirschner wires (K-wires) was described as a feasible and safe alternative. However, clinical follow-up of patients treated with this technique is lacking. To assess patient-reported outcomes (PROMs) in patients treated with PAO with the K-wire fixation technique and to compare it with the screw fixation technique. We conducted an analysis of 202 consecutive PAOs at a single university center between January 2015 and June 2017. A total of 120 cases with complete datasets were included in the final analysis. PAOs with K-wire fixation (n = 63) were compared with screw fixation (n = 57). Mean follow-up was 63 ± 10 months. PROMs assessed included the International Hip Outcome Tool (iHOT 12), Subjective Hip Value (SHV), and UCLA activity score (UCLA). Pain and patient satisfaction (NRS) were evaluated. Joint preservation was defined as non-conversion to total hip arthroplasty (THA). Preoperative baseline PROMs in both fixation groups were similar. In both groups, PROMs (p = <0.001) and pain (p = <0.001) improved significantly. Postoperative functional outcome was similar in both groups: iHOT 12 (71.8 ± 25.1 vs. 73 ± 21.1; p = 0.789), SHV (77.9 ± 21.2 vs. 82.4 ± 13.1; p = 0.192), UCLA (6.9 ± 1.6 vs. 6.9 ± 1.9; p = 0.909), and pain (2.4 ± 2.1 vs. 2.0 ± 2.1; p = 0.302). Patient satisfaction did not differ significantly (7.6 ± 2.6 vs. 8.2 ± 2.2; p = 0.170). Conversion to THA was low in both groups (two vs. none; p = 0.497). Periacetabular osteotomy with K-wire fixation provided good clinical results at mid-term follow-up, comparable to those of screw fixation. The technique can therefore be considered a viable option when deciding on the fixation technique in PAO.

Analysis of predictive factors for post-traumatic osteoarthritis and poor outcomes in acetabular fractures treated surgically.

The aims of this study were (i) to assess the radiological and functional outcomes of surgically treated displaced acetabular fractures and (ii) to analyze the predictive factors of poor outcomes following surgery. A total of 119 patients (24 female, 95 male) who were operated between 2009 and 2019 were included in the study. The mean age was 47.5 years (range=18-61). The mean follow-up was 92.3 months (range=24-120). Failure to preserve the biological hip joint, as treated with total hip replacement or the Girdlestone procedure, was defined as a poor outcome. Patients' demographic information, comorbidities, fracture types, surgical approach, concomitant injuries, reduction quality, and complications were analyzed. Computed tomography was utilized to evaluate the fracture type and quality of reduction. Factors affecting poor outcomes were analyzed by logistic regression analysis. The modified Harris Hip Score was also used to evaluate the functional status. The poor outcome rate was 10.1%. Multivariate logistic regression analysis revealed that dislocation (odds ratio: 44.87, confi- dence interval: 3.18-633.22, P=.005), wound site problems (odds ratio: 9.09, confidence interval: 1.01-81.12, P=.04), reduction quality (odds ratio: 77.88, confidence interval: 5.95-1019.07, P = .001), and diabetes (odds ratio: 7.29, confidence interval: 1.01-52.07, P = .04) were associated with poor outcomes. Eight of the 12 patients with poor outcomes had a fair Harris Hip Score, and 4 had a poor Harris Hip Score. The relationship between poor outcomes and Harris Hip Score was found to be significant (P < .001). For a favorable functional outcome in acetabular fractures, preservation of the biological hip joint should be a top priority. The accompanying dislocation and the patient's diabetes appear to be uncontrollable factors for the poor prognosis. Good reduction qual- ity and wound infection protection are modifiable factors. Level IV, Therapeutic Study.

Delaying anterior cruciate ligament reconstruction increases the rate and severity of medial chondral injuries.

The aim of this study was to evaluate the association between chondral injury and interval from anterior cruciate ligament (ACL) tear to surgical reconstruction (ACLr). Between January 2012 and January 2022, 1,840 consecutive ACLrs were performed and included in a single-centre retrospective cohort. Exclusion criteria were partial tears, multiligament knee injuries, prior ipsilateral knee surgery, concomitant unicompartmental knee arthroplasty or high tibial osteotomy, ACL agenesis, and unknown date of tear. A total of 1,317 patients were included in the final analysis, with a median age of 29 years (interquartile range (IQR) 23 to 38). The median preoperative Tegner Activity Score (TAS) was 6 (IQR 6 to 7). Patients were categorized into four groups according to the delay to ACLr: < three months (427; 32%), three to six months (388; 29%), > six to 12 months (248; 19%), and > 12 months (254; 19%). Chondral injury was assessed during arthroscopy using the International Cartilage Regeneration and Joint Preservation Society classification, and its association with delay to ACLr was analyzed using multivariable analysis. In the medial compartment, delaying ACLr for more than 12 months was associated with an increased rate (odds ratio (OR) 1.93 (95% confidence interval (CI) 1.27 to 2.95); p = 0.002) and severity (OR 1.23 (95% CI 1.08 to 1.40); p = 0.002) of chondral injuries, compared with < three months, with no association in patients aged > 50 years old. No association was found for shorter delays, but the overall dose-effect analysis was significant for the rate (p = 0.015) and severity (p = 0.026) of medial chondral injuries. Increased TAS was associated with a significantly reduced rate (OR 0.88 (95% CI 0.78 to 0.99); p = 0.036) and severity (OR 0.96 (95% CI 0.92 to 0.99); p = 0.017) of medial chondral injuries. In the lateral compartment, no association was found between delay and chondral injuries. Delay was associated with an increased rate and severity of medial chondral injuries in a dose-effect fashion, in particular for delays > 12 months. Younger patients seem to be at higher risk of chondral injury when delaying surgery. The timing of ACLr should be optimally reduced in this population.

High Tibial Osteotomy for knee joint preservation: “Old but Gold”!

High Tibial Osteotomy for knee joint preservation: “Old but Gold”!

The Principles of Knee Joint Preservation: Operative Treatment Strategies.

➤ Joint alignment, meniscal status, and ligament stability are codependent factors involved in knee joint preservation, and any injury or imbalance can impact the knee articular cartilage status and can result in adverse clinical outcomes.➤ Cartilage preservation procedures in the knee will not result in optimal outcomes if there is joint malalignment, meniscal deficiency, or ligamentous instability.➤ Lower-extremity varus or valgus malalignment is a risk factor for the failure of an anterior cruciate ligament (ACL) reconstruction. It represents an indication for a high tibial osteotomy or distal femoral osteotomy in the setting of failed ACL reconstruction, and may even be considered in patients who have an initial ACL injury and severe malalignment.➤ An elevated posterior tibial slope increases the risk of failure of ACL reconstruction, whereas a decreased posterior tibial slope increases the risk of failure of posterior cruciate ligament reconstruction.

Superior Capsular Reconstruction for Massive Irreparable Cuff Tears: A Systematic Review for Clinical &amp; Functional &amp; Radiological Outcomes

Background Massive rotator cuff tears (MRCT) are defined as a full-thickness tear of at least two tendons or measuring greater than five centimeters in diameter in the coronal plane. They represent about 20% of all rotator cuff tears and 80% of recurrent tears. Aim of the Work The treatment of massive irreparable cuff tears (MIRCT) is considered a consistent challenge for the orthopedic surgeons regarding the best management and the postoperative outcomes. Patients and Methods Search were conducted using the following databases: MEDLINE database, PubMed, Cochrane Bone and Muscle Trauma Group Specialized Register, Cochrane Register of Controlled Trails (The Cochrane Library). Data will be independently extracted by two reviewers and cross-checked. Results In radiological parameters, this review makes radiological assessment based on acromiohumeral distance and MRI graft integrity. AHD showed significant improvement in mean change postoperatively rather than preoperatively. As regarding MRI graft integrity, despite this high failure rate (20%) most patients still experienced improved functional outcome scores with two studies reporting no significant differences in functional scores between the intact and re-tear group. but on the other hand Denard et al. demonstrated that 100% of patients with healed grafts had a successful outcome compared to 45.5% when the graft did not heal (p = 0.009). Conclusion Not all patients with massive cuff tears are appropriate candidates for complex joint preservation surgery such as SCR because of age, comorbidities, and ability to participate in the lengthy postoperative rehabilitation, so rTSA is an optimal option for elderly, low-demand patients who can benefit from the speed of surgery and rehabilitation with rTSA for massive rotator cuff tears without arthritis.

Unicompartmental Knee Arthroplasty Provides Superior Clinical and Radiological Outcomes Compared to High Tibial Osteotomy at a Follow-Up of 5-8 Years.

Knee Osteoarthritis (OA) is a debilitating disease. Initially, the medial compartments are affected in most cases. For this pathology, joint preservation is preferable. Two surgical procedures aim to meet this goal: high-tibial osteotomy (HTO) and unicompartmental knee arthroplasty (UKA). The aim was to compare clinical and radiological outcomes of HTO versus UKA in patients with unicompartmental, medial OA. Retrospective case series. A total of 86 (61 UKA, 25 HTO) patients that received either treatment at a single, specialized center were assessed pre-operatively and at a single follow-up examination at 77.13 months (±8.170). The Knee Society Score (KSS), range of motion (ROM), SF36 questionnaire and the Tegner score were used. The Kellgren-Lawrence score was assessed pre- and post-surgically. Survivorship with the endpoint "revision" was assessed. The UKA group showed significantly better improvements in KSS scores for pain (p < 0.006) and function (p < 0.001). OA progression (p < 0.02) and survivorship (p < 0.018) differed, significantly favoring UKA. ROM, SF36 and Tegner score did not differ significantly. The presented mid-to long-term data suggest that UKA provides superior results in selected outcomes. Nevertheless, significant differences in the demographics of treatments indicate the challenge of comparing these two treatments.

Histomorphological Investigation of Microfracture Location in a Rabbit Osteochondral Defect Model.

Microfracture is the most common treatment for cartilage defects of the knee. In microfracture surgery, holes are randomly drilled into the subchondral bone. The effect of the hole's location on its interaction with the cartilage defect site and its influence on the healing process is currently uncertain. To investigate the effects of different microfracture locations on healing in a rabbit knee osteochondral defect model. Controlled laboratory study. A total of 29 adult New Zealand White rabbits were divided into 5 groups. In the healthy cartilage control group (n = 5), no surgical procedure was performed. Cylindrical full-thickness cartilage defects (5 × 3 mm) were created in the patellar groove of the remaining 24 rabbits. In the defect control group (n = 6), only the defect was created. A microfracture was performed at the 12-o'clock position (group peripheral single; n = 6), centrally (group central; n = 6), and at the 12- and 6-o'clock positions (group peripheral double; n = 6) of the defect. The animals were sacrificed after 8 weeks. Cartilage healing was evaluated by International Cartilage Regeneration & Joint Preservation Society (ICRS) score, modified O'Driscoll score, immunohistochemical analysis (type 1 collagen, type 2 collagen, and aggrecan), and scanning electron microscopy analysis. In group peripheral double, better cartilage healing was observed in all parameters compared with the other groups (P < .05). Group peripheral double had the greatest amount of filling, with 79% of the defect area filled with fibrocartilage repair tissue. Group peripheral single demonstrated filling of 73% of the defect area, group central 56%, and the defect control group 45%. The ICRS score was significantly higher in group peripheral single compared with group central and the defect control group. Type 2 collagen and aggrecan immunoreactivity were significantly stronger in group central than group peripheral single and the defect control group (P < .05). Microfracture performed at the peripheral margin of the defect had better filling characteristics in a rabbit model. This study suggests that interaction of pluripotent cells released from the microfracture site with the intact cartilage may enhance the quality of the repair tissue. The location of microfracture holes in relation to the peripheral border of the osteochondral defect (to the intact cartilage) is important in both the quality and the quantity of the newly formed repair tissue.

A Retrospective Study Assessing the Clinical Outcomes After Cheilectomy and Subchondroplasty for Hallux Rigidus.

Introduction Hallux rigidus (HR) refers to osteoarthritis of the first metatarsal phalangeal joint, resulting in stiffness, pain, and limitation in daily function. Surgery of HR is indicated in those who have failed a trial of non-operative managementand is typically divided into joint-preserving (JP)and joint-sacrificing procedures. Cheilectomy is the most commonly practiced JP procedure, often done in conjunction with associated procedures for HR. Our paper aims to report the clinical outcomes after cheilectomyand cheilectomy done with subchondroplasty (SCP)performed for HR. Methods All patients who underwent cheilectomy for HR between 2017 and 2022 were identifiedand had their outcomes evaluated at the time of this review. The patients had their pre-operative radiographs and clinical and operative notes analyzed for the grading of HR. Functional outcomes were assessed with the use of the visual analogscale (VAS) and American Orthopaedic Foot and Ankle Society (AOFAS) scores, as well as comparing the pre-operative and post-operative degree of dorsiflexion of the affected first metatarsophalangeal joint. This study was approved by the SingHealth Institutional Review Board (IRB) Institutionwith approval number 2021/2629. Results A total of 19 patientsand 20 feetwere included in our study at a mean follow-up of 29.8 months. There was an increase in dorsiflexion of the first MTP joint by 27.2 degrees (p-value = <0.0001). Patients who underwent cheilectomy alone (Group 1) had a mean improvement in VAS scores of 5.46 (p-value = <0.0001). Patients who underwent SCPof the first metatarsal head along with cheilectomy (Group 2) had an improvement in VAS scores by 5.78 (p-value = 0.0007). There was a mean improvement in AOFAS scores of 25.6 (p-value = <0.0001) for patients in Group 1. Patients in Group 2 had a mean improvement in AOFAS scores of 31.0 (p-value = 0.0003). Conclusion Both cheilectomy and cheilectomy performed with SCP for HR showgood outcomes at short-term follow-up (mean 29.8 months). Cheilectomy is a viable alternative to arthrodesis for the surgical treatment of HR even in patients with higher grades. The use of SCP should be further explored as an adjunct in the surgical treatment of HR.

Evaluation of muscle strength recovery following superior capsular reconstruction using a tensor fascia lata graft: A comparison with the unaffected side.

Superior capsular reconstruction (SCR) using a tensor fascia lata graft has been performed in patients with irreparable rotator cuff tears and shoulder pseudoparalysis (PPS), and good clinical results have been reported. This procedure can be indicated for younger patients who are highly active in sports and manual labor from the viewpoint of joint preservation. However, this procedure supplements the defect with a graft that has no muscle contractility; therefore, the extent to which shoulder muscle strength is recovered after SCR remains unclear. We hypothesized that the recovery of muscle strength after SCR would not be normalized and would be only approximately 50% of that of the healthy (unaffected) side. This study aimed to evaluate muscle strength after SCR in patients with PPS due to irreparable rotator cuff tears and the extent of recovery by comparing with that of the unaffected side. In total, 20 patients who underwent SCR for PPS using a tensor fascia lata graft with a minimum 2-year follow-up were included. Shoulder muscle strength in abduction, internal rotation, and external rotation was evaluated using a handheld dynamometer. Muscle strength was compared to that on the unaffected side, and the affected/unaffected ratio was measured. Shoulder range of motion (ROM) and acromiohumeral distance (AHD) were also evaluated. The postoperative ROMs and AHD (4.0 ± 1.4 mm vs. 8.4 ± 1.9 mm, P < .001) were significantly improved compared to those preoperatively. In external and internal rotation, the muscle strength of the affected side was recovered by approximately 80% compared to that of the unaffected side. However, in abduction, the muscle strength of the affected side (2.9 ± 1.5 kg) could not reach 50% (48.0 ± 15.9%, range: 25.0-76.5%) of that of the unaffected side (5.9 ± 1.8 kg). Abduction strength was not sufficiently restored after SCR when compared to that on the unaffected side.

Managing Difficult Problems in Small Joint Arthroplasty: Challenges, Complications, and Revisions.

Small joint arthroplasty of the hand has been an established means of joint preservation and pain relief for over a half a century. Despite this, metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joint arthroplasty has not achieved the long-term success seen with hip and knee arthroplasty. Problems following MCP, PIP, and carpometacarpal (CMC) joint arthroplasty can include intraoperative fracture, postoperative dislocation, recurrent pain, limitation of motion, and instability. The hand surgeon needs to be prepared for these problems and their management. This article addresses the management of the most common complications seen following MCP, PIP, and CMC arthroplasty.

Single-step ultra-purified alginate gel implantation in patients with knee chondral defects.

Implantation of ultra-purified alginate (UPAL) gel is safe and effective in animal osteochondral defect models. This study aimed to examine the applicability of UPAL gel implantation to acellular therapy in humans with cartilage injury. A total of 12 patients (12 knees) with symptomatic, post-traumatic, full-thickness cartilage lesions (1.0 to 4.0 cm2) were included in this study. UPAL gel was implanted into chondral defects after performing bone marrow stimulation technique, and assessed for up to three years postoperatively. The primary outcomes were the feasibility and safety of the procedure. The secondary outcomes were self-assessed clinical scores, arthroscopic scores, tissue biopsies, and MRI-based estimations. No obvious adverse events related to UPAL gel implantation were observed. Self-assessed clinical scores, including pain, symptoms, activities of daily living, sports activity, and quality of life, were improved significantly at three years after surgery. Defect filling was confirmed using second-look arthroscopy at 72 weeks. Significantly improved MRI scores were observed from 12 to 144 weeks postoperatively. Histological examination of biopsy specimens obtained at 72 weeks after implantation revealed an extracellular matrix rich in glycosaminoglycan and type II collagen in the reparative tissue. Histological assessment yielded a mean overall International Cartilage Regeneration & Joint Preservation Society II score of 69.1 points (SD 10.4; 50 to 80). This study provides evidence supporting the safety of acellular UPAL gel implantation in facilitating cartilage repair. Despite being a single-arm study, it demonstrated the efficacy of UPAL gel implantation, suggesting it is an easy-to-use, one-step method of cartilage tissue repair circumventing the need to harvest donor cells.

Clinical Outcomes After Joint-Preserving and Joint-Sacrificing Surgery for Hallux Rigidus.

Introduction Hallux rigidus (HR) is a degenerative condition affecting the first metatarsal phalangeal joint, causing stiffness and pain. Surgery is indicated for those who have failed a trial of conservative management. The purpose of this paper is to evaluate the functional outcomes at short and medium term after surgery for HR. Methods All patients who underwent surgical treatment for HR between 2017 and 2022 at the time of this study were identified and invited to return for a follow-up evaluation. Outcomes were assessed by comparison of pre-operative and post-operative visual analogue scale (VAS) and American Orthopaedic Foot and Ankle Society (AOFAS) scores. Results A total of 26 patients were included in our study with a mean follow-up of 31 months. There was a mean improvement in VAS score by 5.6 (p-value < 0.0001) and 5.7 (p-value = 0.0012) in patients who underwent joint-preserving (JP) and joint-sacrificing (JS) surgery, respectively. Patients who underwent JP surgery had a mean increase of 28.1 points (p-value < 0.0001) in the AOFAS Hallux score, while patients who underwent JS surgery had a mean increase of 27.29 points (p-value = 0.0066). Conclusion Functional outcomes after surgical management for HR are good at short- and medium-term follow-up. Good outcomes are seen with both JP and JS procedures. JP procedures should be considered as a first-line surgical option for HR as it allows revision procedures if required.

Poster 270: Joint Preservation and Complications of Tibial Tubercle Osteotomy at a Minimum of 5- Year Follow-up

Objectives: To report the incidence of complications after TTO at a minimum of 5-year follow-up. As a secondary outcome, we aimed to identify predictors of postoperative complications. As a tertiary outcome, we aimed to report the rate of progression of knee osteoarthritis. We hypothesized that recurrent instability following TTO is rare and the rate of progression of knee osteoarthritis is slow Methods: Patients undergoing primary TTO between January 1, 2010, and December 31, 2015, and having a minimum of 5-year clinical follow-up data were included. Exclusion criteria were patients with shorter than 5-year follow-up, revision TTO, TTO following total knee arthroplasty, concomitant anterior cruciate ligament reconstruction, history of or concomitant distal femoral osteotomy, history of soft tissue procedures or trochleaplasty for patellar instability, congenital patella dislocation or patellar instability secondary to a congenital disorder/syndrome. Clinical and radiographic outcomes were collected on a RedCAP database. Risk factors for complications were identified using multivariable logistic regression analysis. Results: A total of 72 (50 female/22 male) patients were included in the analysis. The median age was 22.0 years. The mean follow-up period was 104.8 months (67-138). Sixty-four patients underwent anteromedialization TTO and 8 underwent medialization TTO. The median BMI was 26.4 kg/m2. Sixty-six patients had isolated TTO, and 11 patients had TTO and concomitant medial patellofemoral ligament reconstruction. One screw was used in 5 patients and 2 screws in 67 patients. Tibial tubercle was distalized in 25 patients and not distalized in 47 patients. Fifty-six patients reported they never smoked before their surgery and 15 patients reported they smoked at some point in their lives before the surgery. The overall complication rate was 30.5% (22/72). The incidence of major complications was 6.9%. Univariate logistic regression analysis on complications revealed patients who ever smoked are more likely to experience a postoperative complication (OR=4.33 (1.29, 14.53), p-value = 0.018). Multivariable model for complication, using TTO Procedure as the main predictor revealed TTO procedure (TTO vs TTO+STP), number of screws, and distalization didn’t affect complication rates. Multivariable model for complication, using TTO Technique (AMZ vs MZ) as the main predictor, revealed no difference in TTO technique. The mean radiographic follow-up was 67 moths. The preoperative rate of patients with Kellgren-Lawrence grade III-IV increased from 11.7% to 18.8% at the last follow-up. The rate of patients with an osteophyte on knee radiographs was 33.3% before surgery and increased to 39.1% at the last follow up. Of 72 patients, 12 were athlete. Rate of return to sports was 91.6% (11/12) after TTO procedure. Mean time to return to sports was 27.6±10.2 weeks. Conclusions: Tibial tubercle osteotomy is a viable option for the treatment of patellar instability with low recurrence and major complication rates at mid and long-term follow-up. It successfully prevents and slows the progression of knee osteoarthritis by changing the contact biomechanics. Patients who smoke should be counseled about the increased risks of complications before the surgery. [Table: see text][Table: see text][Table: see text][Table: see text]

Poster 300: A Novel Magnetic Resonance Imaging (MRI) Scoring System to Evaluate Patellofemoral Osteoarthritis

Objectives: Knee osteoarthritis (OA) is a common degenerative or post-traumatic condition, and may affect one or more compartments, including the medial and lateral tibiofemoral or patellofemoral articulations. Isolated patellofemoral osteoarthritis (PFOA) has been reported in 24% of women and 11% of men aged &gt; 55 years presenting for evaluation of knee pain. PFOA is a result of abnormal mechanical loading across the patellofemoral joint, often related to prior instability, trauma, malalignment or post- surgical changes. Treatment of PFOA typically includes a trial of conservative management, including physical therapy, injections and activity modification. Operative treatment involves joint preservation (i.e., cartilage restoration procedures, tibial tubercle osteotomy, or lateral lengthening) and joint replacement (patellofemoral arthroplasty) procedures. In contrast to the tibiofemoral compartments, the current literature lacks a reliable magnetic resonance imaging (MRI) scoring system to quantitatively evaluate patellofemoral cartilage degeneration. The present study aims to describe, apply and assess the inter-observer reliability of a novel MRI scoring system for assessment of the patellofemoral cartilage. Methods: We conducted a query of an institutional database to identify all patients who underwent patellofemoral arthroplasty by the senior surgeon (S.M.S.) between January 2012 and December 2021. Patients with poor quality or lacking preoperative knee MRI were excluded. MRI scans were performed on 1.5 or 3.0-Tesla magnets utilizing dedicated extremity coils and standardized clinical imaging protocols consistent with International Cartilage Regeneration and Joint Preservation Society (ICRS) guidelines for the assessment of articular cartilage. Preoperative MRI scans were reviewed and patellofemoral cartilage was scored by a fellowship-trained musculoskeletal radiologist and a fellowship- trained orthopedic knee surgeon using our novel MRI scoring system. The novel semi-quantitative MRI patellofemoral scoring system includes assessment of patellar and trochlear cartilage, bony architecture, patellofemoral alignment, and synovitis (Table 1). For statistical analysis, inter-observer agreement was assessed using Cohen-Kappa coefficient for categorical variables, and intraclass correlation coefficient (ICC) for the total score. The measurement agreement for reach variable and total score was interpreted according to the Landis and Koch criteria: 0 - 0.2, slight; 0.21 - 0.4, fair; 0.41 - 0.6, moderate; 0.61 - 0.80, substantial; 0.81 - 1.0, almost perfect. Results: A total of 72 patients were included in the final analysis. The mean (± standard deviation) age and body mass index (BMI) of all patients was 53.30±7.72 years and 27.3±5.37 kg/m, respectively. Patellar bone edema and patellar cysts demonstrated moderate inter-observer agreement. All cartilage features, trochlear bone edema and cysts, osteophytes, subchondral remodeling, patellar height, and synovitis demonstrated substantial inter-observer agreement. Patellofemoral alignment and total score demonstrated almost perfect inter-observer agreement (Table 2 and Figure 1). Conclusions: The novel MRI scoring system for PFOA proposed by the authors is an attempt to develop a comprehensive method to assess patellofemoral joint cartilage degeneration, including evaluation of patellar and trochlear cartilage changes, bony architecture, patellofemoral alignment, and synovitis. Importantly, all features of the scoring system demonstrated at least moderate inter-observer agreement, with the majority of variables and total score demonstrating substantial to near perfect agreement. Future studies should aim to validate this scoring system in patients with and without patellofemoral arthritis and attempt to correlate scores with clinical outcomes. [Table: see text][Table: see text]

Paper 52: Pre- and Post-operative Patient Management by an Integrated Care Team Reduces Postoperative Failure Rates Following Osteochondral Allograft Transplantation in the Knee

Objectives: To assess the effects of an integrated care team including a health behavior psychologist on postoperative adherence and associated outcomes for patients undergoing osteochondral and/or meniscus allograft transplantation in the knee. Methods: With IRB approval and documented informed consent, patients were prospectively enrolled into a registry dedicated to following outcomes after OCA and meniscus allograft transplantation surgery between January of 2016 and April of 2021. Patients undergoing primary osteochondral and/or meniscus allograft transplantation to address symptomatic full-thickness cartilage loss and/or meniscus deficiency were included. Patient adherence rates and outcomes were compared based on two cohorts: patients that did not see a behavioral health psychologist preoperatively, and patients that met preoperatively identify potential barriers to adherence, set expectations for postoperative protocols, and identify a plan to moderate risk factors to non-adherence. Patients in both cohorts met preoperatively with the rest of the integrated care team specializing in joint preservation. Data were collected preoperatively, and at all follow-up visits at 3 months, 6 months, and yearly post-operatively. Visual analog scale (VAS) pain scores, International Knee Documentation Committee scores, PROMIS Global Health, and PROMIS Pain interference scores were collected. Treatment failure was defined as any reoperation to revise any of the osteochondral and/or meniscus allografts (revision) or for conversion to arthroplasty in the affected knee. Functional survival (success) was defined as patient- reported pain and function scores improved from pre-operative levels without need for revision or arthroplasty. Patients were categorized as nonadherent when documented evidence of a break from the physical therapy protocol was recounted to a member of the healthcare team by the patient or their physical therapy provider. Data were included for analyses when applicable registry data were available for at least one year following surgery. Chi-square or Fisher’s exact tests were used to analyze differences in proportions, while unpaired t-Tests, one-way analysis of variance tests, or rank sum tests were used to assess significant differences in variables with continuous data. Significance was set a priori at p &lt; 0.05. Results: For patients in the study (n=213), 23.4% were documented to be nonadherent. Of those who were nonadherent, 4 (8.0%) were in the Health Psych cohort versus 46 (92.0%) who were not. Patients in the No Health Psych cohort were significantly more likely to be nonadherent to postoperative rehabilitation protocols (p = .023, OR = 3.4). Tobacco use (p&lt;.001, OR = 7.9), higher preoperative PROMIS Pain Interference score (p&lt;.001), lower preoperative PROMIS Mental Health score (p&lt;.001), older age (p&lt;.001) and higher BMI (p&lt;.001) were also significantly associated with nonadherence. 81.6% of adherent patients had successful outcomes (mean final follow-up 46.7 months, range 12-75), while 40% of nonadherent patients required revision or total knee arthroplasty during the study period, such that nonadherent patients were 3x more likely (p = .004) to experience treatment failure. In this cohort of patients, male sex (p&lt;.001, OR = 3.4) and bipolar OCA transplantation surgeries (p&lt;.001, OR = 5.0) were also significantly associated with increased risk for treatment failure. Conclusions: Preoperative education and postoperative support for patients provided by an integrated care team including a health psychologist can significantly improve adherence and outcomes following osteochondral and meniscal allograft transplantation in the knee.

Decreased Synovial Fluid Ghrelin Level Is Associated With Acute Cartilage Injury in Patients With Anterior Cruciate Ligament Tear.

Ghrelin, an amino acid hormone secreted primarily from the stomach, can regulate bone metabolism, regulate inflammation via suppressing proinflammatory cytokines, and suppress expression of matrix metalloproteinases (MMPs). To measure synovial fluid levels of ghrelin in young patients with anterior cruciate ligament (ACL) tear to assess the role of ghrelin as a potential biomarker for cartilage injury. Controlled laboratory study. This study included 120 patients who underwent ACL reconstructionbetween January 1, 2016, and May 31, 2021. We categorized 60 patients with acute cartilage injury (International Cartilage Regeneration & Joint Preservation Society grade 2 or 3) as the acute group and 60 patients with no acute cartilage injury as the nonacute group, with the healthy contralateral knee of each patient acting as the control group (n = 120). Synovial fluid samples were collected from the knees in the operating room before ACL reconstruction. We assessed the inflammatory biomarkers interleukin (IL)-6, MMP-1, MMP-9, and MMP-13, as well as serum ghrelin level and Mankin score, and results were compared between the 3 study groups with the Mann-Whitney U test. Lower serum ghrelin levels in the synovial fluid were found in the acute group compared with the nonacute group and healthy controls (232.4 vs 434.4 vs 421.5 pg/mL, respectively; P < .001). Ghrelin level in the synovial fluid was significantly and positively correlated with IL-6 (r = 0.4223; P < .0001), MMP-13 (r = 0.3402; P < .0001), and Mankin score (r = 0.1453; P = .0244). In patients with ACL injury, ghrelin synovial fluid was significantly differently expressed in patients with cartilage injury and no cartilage injury. Ghrelin synovial fluid has the potential to be a biomarker to predict acute cartilage injury in patients with ACL injury.