BackgroundPartial squats are a part of many rehabilitation programs. Progress to deeper squats can only be performed through the partial squat position. However, squats safety, onset time, and rational depth are still controversial. Most previous studies have not considered the influence of posterior tibial slope (PTS) and anterolateral ligament (ALL) on the stress on the knee anatomical elements in partial squats. MethodsWe have created the new comprehensive knee computer models, which considered muscle exertions while weight bearing 75, 100, 125, and 150 kg in partial squats, included the ALL, two variants of PTS (5° and 13.9°), and two variants of anterior cruciate ligament (ACL) (a native 6 mm double-bundle ACL and an 8 mm single-bundle ACL graft). Using the finite element analysis, we have analyzed stresses in 14 anatomical elements in each model in partial squats (55° knee flexion and 10° anterior tibia tilt). ResultsPTS change from 5° to 13.9° in a partial squat increases stress 1.2–1.3 times on the native ACL and 1.3–1.4 times on the ALL. In the case of single-bundle ACL reconstruction, PTS growth from 5° to 13.9° results in stress increasing 1.2–1.3 times on the graft and 1.3–1.4 times on the ALL. Thus, increased PTS is a significant risk factor, especially in the early postoperative period. Weight-bearing predictably increases stress on the ACL, ALL, and other joint elements proportional to the weight growth.Patients with thinner grafts after the ACL reconstruction may already reach the risk level for graft rupture in a single load in partial squatting if they weigh 125 kg or more. The risk rises with increasing PTS angle or the patient's weight. Because of the reduction of the graft strength by six weeks after surgery by 27%, partial squats in six weeks are associated with forces that may exceed the maximal ACL load even in patients with 75 kg of weight without additional load. ConclusionIn the early postoperative period, partial squats can put the ACL graft at risk of failure. This risk is proportional to the patient's weight and PTS angle, and inversely proportional to the graft thickness. The choice of physical therapy strategies after ACL reconstruction, exercises, and their initiation timing is complex and cannot be standardized for all patients. Factors like the thickness of the graft, the method of fixation, the patient's weight, the ALL insufficiency, the PTS angle, and the patient's goals in the short and long term should be considered when planning the rehabilitation program.