This paper seeks to use motivator-hygiene theory as a lens to investigate how job satisfaction influences turnover intentions of faculty of private university colleges in addition to how organizational commitment mediate the relationship between job satisfaction and turnover intentions of faculty of private university colleges. The study argues that job satisfaction has a negative relationship with turnover intentions and a positive relationship with organizational commitment. The model and hypothesized relationships developed in this study were examined using survey data from faculty of private university colleges affiliated to the Kwame Nkrumah University of Science and Technology (KNUST) in Ghana. The exploration of data gathered was done using the Statistical Package for Social Sciences Version 22. Test conducted include frequency test and regression analysis which was used to examine the developed hypothesis. The findings revealed that job satisfaction has a significant negative effect on organizational commitment.