Background: The sustainability and strength of an organization strongly depends on the mental, physical, and physiological health of its employees. The purpose of this study is to investigate the effect of fatigue and stress on the incidence of musculoskeletal disorders, job performance and their relationship considering some demographic variables in this society. Methods: This cross-sectional analytical study was conducted in 2017. The study populations were administrative employees of the power plant, and sampling was done by census method. Three standard questionnaires about job fatigue and job performance and Nordic questionnaire were distributed among 62 employees. Data were analyzed by SPSS 20; descriptive statistics and Pearson correlation test. Results: All 62 samples were male, and the mean and standard deviation of their age were 41.52 (7.71) years and the mean of work experience was 12.13 (6.25) years. According to the results, 53% of the samples showed high and very high fatigue; the fatigue score was 3.96 that indicated the moderate level. The job performance score was 38.3, which was considered at the low level. Also, there was an inverse and significant relationship between fatigue and job performance (P = 0.03, r = -0.37), and there was a significant relationship between fatigue, performance and neck and back areas (p <0.05).
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