The 2016 recommended childhood and adolescent immunization schedule has been approved by the American Academy of Pediatrics, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention, the American Academy of Family Physicians, and the American College of Obstetricians and Gynecologists. The 2016 format is similar to the 2015 schedule, with a single schedule for people from birth through 18 years of age. The yellow bars indicate the recommended age range for all children and contain a notation indicating the recommended dose number by age. The green bars indicate the ages for recommended catch-up. The purple bars designate the recommended ages for immunization for certain groups at high risk. A blue bar has been added for the first time and indicates the range of recommended ages for people in non–high-risk groups who may receive a vaccine, subject to individual decision-making. The combined green and purple bar indicates the recommended age when vaccine catch-up is encouraged for certain high-risk groups. The white boxes show the ages when a vaccine is not recommended routinely. The catch-up schedule offers recommendations for children and adolescents 4 months through 18 years of age who start vaccinations late or are >1 month behind.The immunization schedule will not be published in Pediatrics. Readers are referred to the American Academy of Pediatrics Web site (http://redbook.solutions.aap.org/SS/Immunization_Schedules.aspx) or the Centers for Disease Control and Prevention Web site (http://www.cdc.gov/vaccines/schedules/hcp/child-adolescent.html) for the most recent version of the immunization schedule, the full set of footnotes, and the catch-up schedule. This method will ensure that providers have the most current recommendations. In addition, the Web sites include tables (job aids) to assist in clarification of recommended use of Haemophilus influenzae type b vaccine, pneumococcal- and pertussis-containing vaccines as a function of age, the number of doses previously administered, and the time interval since the last dose.Footnotes contain recommendations for routine vaccination, for catch-up vaccination, and for vaccination of children and adolescents with high-risk conditions or in special circumstances. A parent-friendly vaccine schedule for children and adolescents is available at http://www.cdc.gov/vaccines/schedules/index.html. An adult immunization schedule is available at www.cdc.gov/vaccines.These schedules are revised annually to reflect current recommendations for use of vaccines licensed by the US Food and Drug Administration and include the following specific changes from last year:Clinically significant adverse events that follow immunization should be reported to the Vaccine Adverse Event Reporting System. Guidance about how to obtain and complete a form for this system can be obtained at www.vaers.hhs.gov or by calling 800-822-7967. Additional information can be found in the Red Book and at Red Book Online (http://aapredbook.aappublications.org/). Statements from the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention that contain details of recommendations for individual vaccines, including recommendations for children with high-risk conditions, are available at www.cdc.gov/vaccines/pubs/ACIP-list.htm. Information on new vaccine releases, vaccine supplies, and interim recommendations resulting from vaccine shortages and statements on specific vaccines can be found at www.aapredbook.org/news/vaccstatus.shtml and www.cdc.gov/vaccines/pubs/ACIP-list.htm.Carrie L. Byington, MD, FAAP, ChairpersonYvonne A. Maldonado, MD, FAAP, Vice ChairpersonElizabeth D. Barnett, MD, FAAPH. Dele Davies, MD, MS, MHCM, FAAPKathryn M. Edwards, MD, FAAPRuth Lynfield, MD, FAAPFlor M. Munoz, MD, FAAPDawn Nolt, MD, MPH, FAAPAnn-Christine Nyquist, MD, MSPH, FAAPMobeen H. Rathore, MD, FAAPMark H. Sawyer, MD, FAAPWilliam J. Steinbach, MD, FAAPTina Q. Tan, MD, FAAPTheoklis E. Zaoutis, MD, MSCE, FAAPDavid W. Kimberlin, MD, FAAP – Red Book EditorMichael T. Brady, MD, FAAP – Red Book Associate EditorMary Anne Jackson, MD, FAAP – Red Book Associate EditorSarah S. Long, MD, FAAP – Red Book Associate EditorHenry H. Bernstein, DO, MHCM, FAAP – Red Book Online Associate EditorH. Cody Meissner, MD, FAAP – Visual Red Book Associate EditorDouglas Campos-Outcalt, MD, MPA – American Academy of Family PhysiciansKaren M. Farizo, MD – US Food and Drug AdministrationMarc Fischer, MD, FAAP – Centers for Disease Control and PreventionBruce G. Gellin, MD, MPH – National Vaccine Program OfficeRichard L. Gorman, MD, FAAP – National Institutes of HealthNatasha Halasa, MD, MPH, FAAP – Pediatric Infectious Diseases SocietyJoan L. Robinson, MD – Canadian Paediatric SocietyJaime Deseda-Tous, MD, FAAP – Sociedad Latinoamericana de Infectologia PediatricaJane F. Seward, MBBS, MPH, FAAP – Centers for Disease Control and PreventionGeoffrey R. Simon, MD, FAAP – Committee on Practice Ambulatory MedicineJeffrey R. Starke, MD, FAAP – American Thoracic SocietyJennifer M. Frantz, MPH