The rock slope stability under blasting excavation disturbance is an important study content in the fields of hydropower, mining, transportation and other research field. Basing on a potential slip rock mass of the left slope of Jinping-Ⅰ Hydropower Station, using Sarma method of the limit equilibrium analysis and orthogonal experimental design, the paper analyzed the main factors which affect the slope stability, and studied the sensibilities of the slope stability to various factors under blasting disturbance. The results indicate that the slope stability under blasting disturb is very sensitive to the change of internal correlative of potential slip rock mass. The slope stability under blasting disturb is less sensitive to the change of external correlative factors which are result from the blasting.