The pathologist Franz Xaver Lucksch (1872–1952) seems to have been in many ways a rather distinctive personality within the academic landscape of German medicine and medical research in Bohemia. As a member of the generation that grew up during the belle époque, he witnessed all the dramatic turnovers of Central Europe in the twentieth century. A man of considerable scientific ambitions, he became assistant professor (1904) and extraordinary professor (1914) at the Institute of Pathology (Institut für Pathologie) of the German Medical Faculty in Prague under Professor Hans Chiari (1851–1916). Having researched pellagra endemics in Romania in 1910, he returned there in the late 1930s thanks to the support of the Rockefeller Foundation. To the best of our knowledge, he published 48 academic contributions in his lifetime, infectious diseases (including tuberculosis) being the most frequent subject. Lucksch fought in the First World War, ending his military service as a lieutenant colonel of the Austro-Hungarian imperial army. Although he at first considered a professional military career in Austria even after 1918, he eventually returned from Vienna to Prague in 1919. There, he continued his medical work and research as a first assistant, which was the position he held for many years. In public life, he was active in spreading awareness of public health issues – probably in reaction to the autopsies he was carrying out. He emphasised the importance of nutrition and prevention of tuberculosis, a disease highly prevalent in Czechoslovakia at the time. But above all, he focused on physical training (Leibesübungen). In 1929–36, he headed the University Physical Training Centre (Hochschulzentrale für Leibesübungen) at the German University in Prague and the German Educational Course for Physical Training of Teachers. Aside from that, he was also a member of the German Association of Gymnasts. This is how Lucksch became acquainted and rather unfortunately politically involved with Konrad Henlein (1898–1945) and his Nazi movement among the Sudeten Germans of Czechoslovakia. At first, he was an active member but shortly after the German occupation of Bohemia and Moravia in March 1939, he found himself in a rather awkward position when the political movement he had previously endorsed started making problems for his Jewish wife and two children. His son, Franz Lucksch Jr. (1916–1966), became also a physician and made a notable scientific career after 1945. In 1936, Lucksch was appointed interim director of the Institute of Pathology. In the spring of 1939, he retired. As an emeritus, he had two part-time jobs: aside from publishing, he still did some teaching and research at the Institute during the academic year, and, in the remaining period, he worked as a pathologist at the Provincial Institute for the Mentally Ill (Landesanstalt für Geisteskranke) in Kosmonosy (Kosmanos), 65km from Prague. At this institution he performed autopsies of patients who died mainly due to extremely bad conditions. After the war, Lucksch was allowed to stay in Prague, but under rather difficult conditions, including financial issues. In connection with the prosecution of Nazi ‘euthanasia’ crimes in the 1960s, a suspicion emerged that he may have conduced tuberculosis experiments on psychiatric patients. Given the particular circumstances, however, this was highly improbable, neither has anything of that kind been proved in connection with Lucksch.