This presentation relates to the management, treatment, and end-results observed in a group of patients with carcinoma of the cervix uteri encountered on the Gynecological Ward Service at the Jefferson Medical College Hospital during the past two decades. More specifically it represents a follow-up study of the patients seen and treated between Sept. 1, 1921, and Sept. 1, 1937. Thus a sixteen-year survey is made available, showing both the present-day and the five-year survival rates obtained during that period of time. Five, ten, and fifteen year reports of our work have been published previously (1, 2, 3). Opportunity for organizing and developing this clinic was afforded by the writer's former chief, Dr. Brooke M. Anspach, Consulting Gynecologist and Emeritus Professor of Gynecology at Jefferson. The radium employed by the Department of Gynecology is supplied by the Lucy B. Henderson Radium Foundation, of which Dr. William S. Newcomet is Director. The x-ray therapy is administered by and in close co-operation with the Department of Roentgenology, of which Dr. Karl Kornblum is Chief. Reliance upon these sources of assistance is gratefully acknowledged. Patients Observed and Follow-Up Table I is self-explanatory. Seventeen patients were untreated, for various reasons. Nine presented disease so far advanced that no treatment was deemed advisable. Seven signed releases, and 3 of these were subsequently treated elsewhere. One patient, previously treated in a distant city, required no further treatment when she entered our clinic for observation. Six patients are untraced. Two, with advanced disease, were untreated; 3, with advanced disease, were treated, and all of these 5 patients are very probably dead. The sixth patient was alive and in good health when lost sight of eight years after treatment. The relatively high percentage of traced patients is the result of persistent and approved follow-up methods. These include personal attendance at the weekly Follow-up Clinic by the attending chiefs, an appointment system, contact by correspondence, visits by social workers, and co-operation of relatives and family physicians. Extent of Involvement The classification of the extent of disease, as proposed by the late Henry Schmitz, has been consistently followed ever since the establishment of the clinic. For practical purposes we consider it much more satisfactory than the relatively recent classification of the League of Nations, with the numerous subdivisions detailed in the published Atlas of the latter authority. The personal equation can never be entirely eliminated from any system of physical examination, but the probability of error is perhaps reduced when a less complicated scheme is consistently followed. The group to which a patient is assigned when first seen is maintained for the duration of her life. For instance, if a patient primarily classified as Group 3 shows marked regression of the lesion following treatment, we do not reclassify her as Group 2, on the assumption that the extent of the disease as first observed might have been of inflammatory origin, for if such a procedure were followed repeatedly, confusion would surely result. If reactivation of a lesion occurs after primary treatment, and further therapy is given, the initial classification is unchanged.