Event Abstract Back to Event Simulating the Development of the Superficial Patch System Roman Bauer1*, Frédéric Zubler1 and Rodney Douglas1 1 UZH / ETHZ, Institute of Neuroinformatics, Switzerland Injections of neural tracers into various mammalian neocortical areas reveal a common patchy motif of clustered axonal projections (Rockland et al., 1982, Muir et al., 2010). We have used the Java-based simulation framework CX3D (Zubler & Douglas, 2009) to investigate how this patchy connectivity could arise in a single layer (II/III) of neocortex. CX3D allows the simulation of cellular growth in a physical 3D environment that respects forces and diffusion of cellularly secreted substances which can act as guidance cues for axonal growth. Individual neurons in the cortical layer II/III expressed the activator-inhibitor components of a Gierer-Meinhardt reaction-diffusion system (Gierer & Meinhardt, 1972). The steady-state reaction-diffusion pattern across the neurons is approximately hexagonal, and for appropriate parameter settings we could reproduce the surprising linear relationship observed between average patch diameter and inter-patch spacing (Binzegger et al., 2007, Muir et al., 2011). The growth cones at the tips of extending axons used the morphogens secreted by intra-patch neurons as guidance cues to direct their growth and invoke arborization, so yielding a general patchy arborization across layer II/III. We conclude that a simple Gierer-Meinhardt system installed in the neurons of the developing neocortex is sufficient to explain the experimentally observed patchy connectivity. Keywords: computational neuroscience Conference: 4th INCF Congress of Neuroinformatics, Boston, United States, 4 Sep - 6 Sep, 2011. Presentation Type: Poster Presentation Topic: Computational neuroscience Citation: Bauer R, Zubler F and Douglas R (2011). Simulating the Development of the Superficial Patch System. Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics. doi: 10.3389/conf.fninf.2011.08.00068 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Oct 2011; Published Online: 19 Oct 2011. * Correspondence: Dr. Roman Bauer, UZH / ETHZ, Institute of Neuroinformatics, Zurich, Switzerland, bauerr@ini.phys.ethz.ch Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Roman Bauer Frédéric Zubler Rodney Douglas Google Roman Bauer Frédéric Zubler Rodney Douglas Google Scholar Roman Bauer Frédéric Zubler Rodney Douglas PubMed Roman Bauer Frédéric Zubler Rodney Douglas Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.