Leaf Extract Of Jatropha Curcas Research Articles

IN VIVO TESTING OF ANTIPYRETIC LEAVES OF FENCE (JATROPHA CURCAS L) ORIGIN GORONTALO

Jatropha (Jatropha Curcas L) is a plant that has been used empirically as a fever reducer. Fever is one of the symptoms of the disease which is characterized by a significant increase in body temperature. The novelty of this study was due to the effectiveness of Jatropha Curca L. leaf extract as an antipyretic. The purpose of this study was to determine the dose of antipyretic effectiveness of Jatropha Curcas (Jatropha Curcas L) Leaf Extract in Male Mice (Mus Musculus). Extraction by maceration using 96% ethanol solvent. 15 male mice (Mus Musculus) were divided into 5 groups, namely negative control (Na-cmc 1%), positive control (Paracetamol), and the treatment group given Jatropha leaf extract with doses of 150, 200, 250 mg/kgBW. Peptone 10% 1 ml orally as a fever inducer. And observed at 30, 60, 90 and 120 minutes after treatment. The data obtained were analyzed using one-way ANNOVA followed by the LSD test to determine differences between groups. The results showed that the leaf extract of Jatropha Curcas (Jatropha Curcas L) had an antipyretic effect where the most effective dose was at a dose of 250 mg/kgBW because it has a very stable temperature reducing power and effectiveness is comparable to Paracetamol. The conclusion of this study is that Jatropha Curcas L extract at a dose of 250 mg/kg can be used as an antipyretic.

Efficacy of Jatropha curcas Leaf Extract on Some Isolates Associated with Surgical Wounds

Aim: The aim of this study is to determine the antibacterial efficacy of Jatropha curcas leaf extract against some isolates associated with surgical wounds.
 Study Design: This was a hospital-based study conducted in 2017 in the Department of medical microbiology unit of Bingham university teaching hospital and the national veterinary research institute (NVRI) both institutions are located in Jos Plateau State Nigeria.
 Methodology: A total of twenty (20) isolates from clinical specimens of surgical wounds were used. The following bacteria were identified using biochemical analysis: Staphylococcus aureus (15), Pseudomonas aeruginosa (2), and Klebsiella pneumoniae (3). Using standard methods of ethanol and aqueous extraction techniques, the leaves of the Jatropha curcas were examined for phytochemical content. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the isolate were determined using the broth dilution method, while the antibacterial activity of the isolate was observed using the agar well diffusion techniques.
 Results: The result of the phytochemical extraction shows the presence of the following Alkaloids (secondary metabolite) Saponins, Tannins, glycosides, Flavonoids, Oxalate, Terpenoids, Resins and steroids. The ethanol extract of Jatropha curcas exhibited antimicrobial activity against all the test bacteria with higher activity recorded with Staphylococcus aureus (15 mm) followed by Klebsiella pneumonia (12 mm) and Pseudomonas aeruginosa (10 mm). Aqueous extract of Jatropha curcas leaves did not exhibit significant antimicrobial activity against all the test isolates when compared to Ethanol Extraction However Aqueous extract of Jatropha curcas had a slight antimicrobial activity against only Staphylococcus aureus in the range of (5 mm to 7 mm). The MIC value for the ethanol extract of Jatropha curcas ranged from 100mg/ml to 200mg/ml while the MIC value for the aqueous extract was 200mg/ml. 
 Conclusion: The result of the present study shows that the ethanol and aqueous extracts of Jatropha Curcas leaves possess some antibacterial activities. The ethanol extract had higher antimicrobial activity than the aqueous extract on surgical wounds. It could therefore be inferred that these leaves contain bioactive constituents which can effectively inhibit the growth of some microorganisms. The plant could be used as an alternative therapy in the treatment of surgical wounds.

Evaluation of wound healing potential of Jatropha curcas leaf extracts ointment based on wound infection in Wistar rats model

This research study was conducted to evaluate the wound healing potential of ointment formulated with Jatropha curcas leaf extracts based on wistrar rat model. The therapeutic activities of the plant extracts were determined by topical application of the herbal ointment. Wound healing rate took place on the 16th day of post treatment with 1.0 g of J. curcas ointment formulation and 12th day with 2.0 g of the ointment, was similar compared with standard drug Gentamicin ointment (12 days). The control untreated group (62.3±0.51%) rate of wound closure observed persisted beyond the 19th day of post-wounding. The haematological parameters of the infected rats treated with herbal ointment and the control group untreated were not significant different (p>0.05). Significant increase in white blood cell (WBC) count in untreated group was recorded when compared with the treated group. However, treatment with the formulated ointments significantly increase the elevated WBC count in the treated group. The toxicological parameters in the serum of the rats are useful makers for the assessment of tissue damage. The serum Aspartate Transaminase (AST) and Alanine Transaminase (ALT) activities in the treated and untreated experimental groups were not significantly (p>0.05) different. The phytochemical components found in J. curcas leaves contain some useful potential antimicrobial agents that possess wound healing properties when formulated into a topical ointment for topical application.

Synthesis, Characterization and Antibacterial Activity Studies of Eco-Friendly Silver Nanoparticles from the Leaf Extract of Jatropha Curcas

Production of environmentally amenable silver nanoparticles (AgNPs) has earned the interest of the scientific community owing to their broad applications, primarily in the field of optronics, sensing, and extensively in pharmaceuticals as promising antioxidant, antimicrobial and anticancer agents. Conventionally silver nanoparticles are synthesized by a chemical method using chemicals as reducing agents which later become accountable for various biological risks due to their general toxicity; engendering the serious concern to develop environment-friendly processes. This study explored the production of eco-friendly AgNPs and the investigation of their antibacterial activity using ethanolic leaf extract of Jatropha curcas (LEJC) as the reducing agent and aqueous silver nitrate as the precursor. The characteristics of the synthesized LEJC-AgNPs were studied by ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform Infrared (FTIR) and Scanning Electron Microscope (SEM). The LEJC-AgNPs formation was observed from the colour change of the mixture from dark-yellow to colloidal brown. A distinctive absorption maximum with surface Plasmon resonance at 425 nm confirmed the formation of LEJC-AgNPs and data on SEM analysis have shown that the synthesized nanoparticles were in the nano range and predominantly irregular and spherical in shape. FTIR identified the functional groups present in the extract for the formation of the LEJC-AgNPs. This green synthesis provides an economic, eco-friendly, and clean synthetic route to AgNPs. The assessed antibacterial activity of the LEJC-AgNPs obtained depicts activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Klebsiella Pneumonia (Gram-negative) at 20, 40, and 80 mg/mL respectively. This data is reflective of the role of LEJC-AgNPs as a potential and promising antimicrobial agent against bacterial infections.

Phytochemical Studies and Identification of Bioactive Compounds using High-performance Liquid Chromatography and Gas Chromatography- Mass Spectrometry of Leaf Extract of Jatropha curcas

Chronic, recurring, and remitting inflammatory disease with an unknown cause is inflammatory bowel disease (IBD). It is a condition that affects people throughout their lives and has many consequences because it is clinically common. Numerous risk factors are still unknown, and the pathophysiology of IBD is still not fully understood. There are a variety of side effects associated with conventional ulcerative colitis treatment. Globally, there is a rise in the use of herbal therapy for IBD. The medicinal plant Jatropha curcas (L.) belongs to the Euphorbiaceae family. It is a biofuel plant with a few pharmacological effects that have been researched. The study’s purpose was to discover and investigate the bioactive components in an ethanolic extract of J. curcas. The leaves of L. J. curcas were gathered, shade dried, crushed up, and gradually extracted with ethanol using the soxhlet percolation method. By using fourier-transform infrared spectroscopy (FTIR) and high-performance liquid chromatography (HPLC), the phytoconstituents in the Jatropha leaf extract were confirmed. Along with the interpretation of mass spectra, the isolated chemicals were identified by contrasting their peak areas and retention times. Due to the discovery of possible, bioactive components as a result of the current inquiry, we are now able to investigate biological activity. After that, gas chromatography-mass spectrometry (GC-MS) was used to analyze the crude extracts. A large variety of secondary metabolites were detected in the extracts’ profile, which was then spectroscopically described. The presence of phytoconstituents, including flavonoids, tannins, and triterpenoids significantly reduces internal inflammation and lessens damage to the intestinal mucosa. Herbal treatments work through a variety of processes, including immunological control and antioxidant activities.

Silver Nanoparticles’ Biosynthesis and Characterization with the Extract of Jatropha curcas Leaf: Analysis of Corrosion Inhibition Activity

The plant-mediated nanoparticles synthesis process is gaining popularity because of its effective cost, eco-friendliness, and nontoxic nature. The current study presents the silver nanoparticles (AgNPs) which synthesized with AgNO3 as precursor salt and Jatropha curcas leaf extract. J. curcas leaf extract has phytochemicals that could reduce the precursor metal salt to nanoparticles and act as a capping agent surround the nanoparticles to enhance its stability. Phytochemical screening on J. curcas leaf extract showed that alkaloids, saponins, tannins, flavanoids, steroids, philobatannins, phenols, and cardiac glycosides are contained in the sample. The biosynthesized nanoparticles were investigated by UV-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). UV-vis spectroscopy confirmed the fabrication of AgNPs at 250–400 nm. The solutions’ change of color from pale yellow to reddish brown indicated that AgNPs is formed. XRD analysis revealed that the synthesized AgNPs average crystal size was 36.4 nm. FTIR analysis indicated that the organic residues covered the nanoparticles. The inhibitory properties of the solution of the synthesized nanoparticles and the bulk extract were evaluated using medium carbon steel. The solution of the synthesized nanoparticles (10 ml) showed better corrosion inhibition efficiency of 87.10 % compared with the bulk extract.

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The study was conducted to test the antifungal efficacy of J. curcas leaf extracts against Phaeoisariopsis personata (causal pathogen for groundnut late leaf spot disease) under in vivo conditions, and to identify important phytochemical constituents exhibiting antifungal properties. The results showed that the greatest reduction of late leaf spot disease incidence was achieved by all the Jatropha curcas leaf extracts at the highest concentration (0.5 mg mL-1) as 36.89, 36.59 and 24.67% for chloroform, ethyl acetate and methanolic extracts, respectively. Subsequently, J. curcas leaf extracts treatments enhanced the growth and yield of groundnut compared with the control (untreated). The antifungal effects of J. curcas were supported by the presence of phytochemical constituents identified by GC-MS. Hexadecane; n-hexadecanoic acid; phenol, 2, 4 bis (-dimethylethyl); phytol and hexadecanoic methyl ester were detected as major phytocompounds in J. curcas leaf extracts that were possibly responsible for the antifungal activity. © 2021 Friends Science Publishers

Experimental Investigation on the Performance of a Solar Still Using SiO2 Nanoparticles /Jatropha curcas L

Now, enticing systematic civic since everywhere the world is used in green synthesis and benefit of the simple is eco-friendly with an emergent method of producing nanoparticles (NPs). The aim of a single slope single basin solar still (SBSS) has been synthesized using Silicon dioxide (SiO2) nanoparticles (NPs)/leaf extract of Jatropha curcas L. (JCL) and the productivity enhancements to an evaluation for the photocatalytic treatment of the system. The synthesized SiO2 NPs/JCL has been characterized by XRD (X-ray Diffraction), SEM (Scanning Electron Microscopy) prepared through EDS (X-ray Energy Dispersive Spectroscopy), studied FT-IR (Fourier Transform Infrared) spectroscopy, UV-Vis (UV-Visible spectrophotometer) verified. The SiO2 NPs/JGL was established anatase, and phase phytochemicals involved stabilizing the potential SBSS process. An effect of SBSS is 82.26% during the treatment with synthesizing SiO2 NPs/JCL successfully active for the solar still process. The SBSS has been produced the total summer distillate yield of 8.79 L/day (SiO2 NPs /JCL), winter is 6.49, L/day (SiO2 NPs) to over all of the system at 24 h cycle in the local climatic condition at Vijayawada, Andhra Pradesh, India. The yield of the SBSS using SiO2 NPs/JCL is enhanced due to an energy absorption increased with the nighttime performance process is risen by distillation. Then, the results are absorbed in the basin area and established to the thermal energy with use in a clean-green treatment solution.

Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats

Jatropha curcas Leaf Extract and Fractions Attenuate Hyperglycemia, Tissue Oxidation, and Kidney Dysfunction in Diabetic Rats

One step hydrothermal green approach of CuO/Ag nanocomposites: analysis of structural, biological activities

In this present investigation, CuO/Ag Nanocomposites (NCs) were prepared by one step hydrothermal green method. The Jatropha curcas leaf extract was act as the reducing as well ascapping agent for synthesis of CuO/Ag NCs. The powder x-ray diffraction (PXRD) studies were investigated the crystal phase structure of CuO and Ag nanomaterials. The presence of oxygen vacancies and Cu interstitial defects in the synthesized material was determined by photo luminescence and Raman analysis. The CuO/Ag NCs was evidenced by TEM analysis and elemental composition of the prepared material was identified by EDAX analysis. The green synthesized CuO/Ag NCs exhibited excellent antimicrobial activity and better antioxidant DPPH free radical scavenging activity. The cytotoxicity of CuO/Ag NCs was assayed against osteoblast MC3t3-E1 and able to inhibit the cell growth by dose-dependent manner.

Antimicrobial Activity of Leaves extracts of Jatropha curcas

The present study was carried out to screen and evaluate antimicrobial activity of leaf extract of Jatropha curcas. Aqueous extract of leaves of Jatropha curcas was tested against Escherichia coli, Staphylococcus aureus, Bacillus spp., Pseudomonas aeruginosa which are known to be resistant to various antibiotics. A Jatropha curcas material which was used during this study collected from Sangli district. In this study, we examined the in-vitro effect of extracts of Jatropha curcas on Escherichia coli, Staphylococcus aureus, Bacillus spp., Pseudomonas aeruginosa. Aqueous extracts was prepared from fresh Jatropha curcas leaves. The susceptibility of tested bacteria to extract was determined by measuring the diameter of inhibition zones formed around well in plate. The results showed that the Jatropha curcas leaves possess antimicrobial activity.

Green synthesis of TiO2 nanoparticles using leaf extract of Jatropha curcas L. for photocatalytic degradation of tannery wastewater

Green synthesis is a simple, eco-friendly and emerging approach of synthesizing nanoparticles (NPs) and currently, attracting scientific community from around the world. The objective of the present study was to synthesize green titanium dioxide (TiO2) NPs and evaluate its performance for the photocatalytic treatment of TWW after the secondary (biological) treatment process. TiO2 NPs was synthesized using leaf extract of the biodiesel plant, Jatropha curcas L. in a one-step at room temperature to examine its treatability for tannery wastewater (TWW). Moreover, the green synthesized TiO2 NPs was further characterized by UV–Visible spectrophotometer, Field Emission Scanning Electron Microscopy (FESEM), X-ray Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared (FT-IR) spectroscopy, X-ray Diffraction (XRD), Dynamic Light Scattering (DLS), Brunauer-Emmett-Teller (BET) and Barret-Joyner-Halenda (BJH) analysis. Results confirmed the synthesis and anatase phase of the spherical TiO2 NPs and also unfold the presence of phytochemicals in leaf extract, which might involve in the capping/stabilization of NPs. Further, the green synthesized TiO2 NPs was applied for the first time to testify its potential for the simultaneous removal of chemical oxygen demand (COD) and chromium (Cr) from secondary treated TWW. During the photocatalytic treatment of wastewater in a self-designed and fabricated Parabolic Trough Reactor (PTR), 82.26% removal of COD and 76.48% removal of Cr from TWW was achieved upon the treatment with green synthesize TiO2 NPs, and thus, successfully employed for the wastewater treatment. Overall, the green synthesized TiO2 NPs demonstrated the astounding potential for the in-situ treatment of TWW as an alternative clean-green treatment solution.

Antibacterial Potential of Jatropha curcas Synthesized Silver Nanoparticles against Food Borne Pathogens.

The aqueous leaf extract of Jatropha curcas was used for the synthesis of silver nanoparticles (Jc-AgNps) which were further evaluated for its antibacterial potential against food borne pathogens. J. curcas leaf extract could synthesize stable silver nanoparticles (Zeta potential: -23.4 mV) with absorption band at 430 nm. Fourier transform infrared spectroscopy indicated various biological compounds responsible for capping and stabilizing Jc-AgNps in suspension, while the presence of silver was authenticated by scanning electron microscopy (SEM) equipped with energy-dispersive X-ray. Jc-AgNps were confirmed to be uniform in shape, size and behavior through dynamic light scattering, transmission electron microscopy (TEM), X-ray diffraction, SEM, and atomic force microscopy (AFM) analysis. To investigate the antibacterial activity, disk diffusion and microplate dilution assays were performed and zone of inhibition (ZOI) as well as minimum inhibitory/bactericidal concentrations (MIC/MBCs) were evaluated against selected bacterial strains. Overall results showed that Escherichia coli (ZOI: 23 mm, MBC: 0.010 mg/ml) was the most sensitive organism, whereas Staphylococcus aureus (ZOI: 14.66 mm, MBC: 0.041 mg/ml) and Salmonella enterica (ZOI: 16.66 mm, MBC: 0.041 mg/ml) were the least sensitive against Jc-AgNps. The detailed microscopic investigations using SEM, TEM, and AFM were performed to understand the antibacterial impacts of Jc-AgNps against Listeria monocytogenes. SEM and TEM analysis showed the clear deformation and disintegration of treated L. monocytogenes cells, whereas AFM established a decrease in the height and cell surface roughness (root mean square value) in the treated L. monocytogenes.

Phytochemical Screening and Antimicrobial Activity of Leaf Extract of Jatropha curcas

Phytochemical Screening and Antimicrobial Activity of Leaf Extract of Jatropha curcas

Tumoricidal Activation of Macrophages using Jatropha curcas Leaf Extract: As a Proxy for the Treatment of Cancer

Abstract Background: Jatropha curcas (J. curcas) is a plant rich in methanolic. Macrophages can be activated to become tumoricidal through interactions with immunomodulators. The aim of this study was to investigate the effect of J. curcas leaf extracts on the phagocytic activity of macrophages. Methods: Peritoneal-derived macrophages from male BALB/c mice were obtained using the method of Colligan et al. with some modifications. Latex was added as an antigen to cultures of BALB/c mice macrophages treated with two different concentrations of J. curcas extract and the cultures were observed every 30 minutes for 2 hours. Results: Macrophage latex vacuoles were observed after treatment with 15 μg/mL J. curcas leaf extract, with a mean latex vacuole count of 7.2 vacuoles/cell and a phagocytic index (PI) of 369. Macrophage treatment with 250 μg/mL J. curcas leaf extract produced a mean latex vacuole count of 8.1 vacuoles/cell and a PI of 785. Conclusion: Treatment with J. curcas leaf extracts increased the phagocytic activity of mice macrophages.

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Cocoyam (Colocasia esculenta) also referred to as taro is an herbaceous root crop and its non availability throughout the year has implicated lack of good storage methods. Survey and storage experiments were therefore, conducted at the Department of Crop Science, University of Nigeria, Nsukka to establish the scientific basis for adopting the indigenous technologies by the farmers and indentify the best among the technologies. The experiments were carried out in two phases. Phase (1) involved collection of farm level information on the existing fresh cocoyam preservation practices from the farmers through questionnaire interview while phase (2) involved the storage of cocoyam using some of the technologies based on their frequency of application by the communities. The storage experiment was laid out as 3 x 2 x 4 factorial in completely randomized design (CRD) and replicated four times. The storage techniques (treatments) were Pit + Casia alata + soil, Pit + Jatropha curcas leaf extracts + soil and no extract control. Twenty-four pits of each 0.7 m deep and 0.33 x 0.33 m2 were dug at the experimental field under plantain and banana shades. Out of the 720 farmers sampled, 34.7% used Pit + C. alata leaf + soil to store their cocoyams while only 11% represent those who did not add botanicals. Weight loss from cocoyams treated with C. alata leaf extracts inside storage pits was significantly (P ≤ 0.05) lower than those treated with J. curcas and no treatment control. Similarly, treatment of cocoyams with both J. curcas and C. alata siginificantly (P ≤ 0.05) reduced rot incidence compared to no treatment control but there was no significant effects of these botanicals sprout weight. Among the leaves used for storage of cocoyam in the study area, J. curcas and C. alata leaf extracts outstandingly reduced post-harvest losses of cocoyam suggesting that these botanicals posses some anti fungal or anti bacterial properties that reduced rots in the stored cocoyam.   Key words: Cocoyam, botanical extracts, pit, shade, storage.

Acute Toxicity and Hepatocurative Effect of Aqueous Leaf Extract of Jatropha curcas in Rats

Acute toxicity and effect of aqueous leaf extract of Jatropha curcas (ALEOJC) on carbon tetrachloride (CCl 4) induced hepatotoxicity in albino rats was evaluated. The rats (60) were divided into five groups designated as; I, II, III, IV and Vof which groups I and II has 15 rats each while, group III, IV and V have 10 rats each. Groups II to V were induced with hepato-toxicity using 150 mg/kg body weight CCl 4 intramuscularly. Serum liver marker enzymes were assayed 48hrs after induction of liver injury followed by 2 nd and 4 th weeksof treatment with ALEOJC and Livolin. Oral LD 50 of ALEOJC was found to be 2,792.85 mg/kg. Serum levels of alanine amino transferase (ALT), Aspartate amino transferase (AST), Alkaline Phosphatase (ALP) and bilirubin level were significantly (P<0.05) increased in group II (untreated rats) compared to group I (normal control). Following treatment with ALEOJC {10 mg/kg (Group III) and 1000 mg/kg (Group IV)} orally, once daily for 4 weeks, a significant hepatocurative effect was observed as evident by decreased level of the serum liver marker enzymes, total bilirubin and direct bilirubin and increase in serum albumin. The hepatocurative effect of ALEOJC is comparable to the standard drug livolin (Group V

Dietary Inclusion of Ethanolic Extracts of Jatropha curcas on the Performance and Carcass Characteristics of Broiler Chickens

A study was conducted to evaluate the effect of Jatropha curcas leaf extract on the performance and carcass characteristics of broiler chickens. One hundred and fifty day old Arbor Acre broiler chicks were used. They were divided into five treatments and each treatment was replicated five times. Treatment one, (Negati ve control, no antibiotics), Treatment two (positive control, with antibiotics) while treatments three, four and five had varying inclusion levels of the Jatropha curcas leaf extract (0.25 g/100 kg, 0.50 g/100 kg and 0.75 g/100 kg of feed respectively). Th e birds were raised for a total number forty two days during which, they were fed ad libitum on a deep litter system of management. Weekly weight gained and feed consumed were recorded. Evisceration of carcass was done after forty two days; each part was w eighed and recorded. Performance characteristics indicated no significant (P>0.05) difference in feed consumed and feed conversion ratio, but treatment 4 with 0.50 g/100 kg of Jatropha curcas extract has the best feed conversion ratio, but there were signi ficant (P<0.05) differences in total weight gain.

Hepatoprotective potentials of the methanolic leaf extract of Jatropha curcas (LINN) on cadmium induced toxicity in rabbit

This study was carried out to investigate the possible hepatoprotective potentials of methanolic leaf extract of Jatropha curcas Linn on cadmium induced hepatotoxicity and oxidative stress in rabbits. Sixteen matured rabbits were used for the study; they were divided into four groups and treated as follows: Group I (control) was treated with normal saline (0.85% w/v NaCl) at 2 ml/kg body weight per day. Group II were treated with only cadmium chloride at 1.25 mg/kg body weight per day. Groups III and IV were pre-treated with 300 mg/kg body weight per day of Jatropha curcas extract and vitamin E respectively, one hour later, cadmium chloride was administered to them at 1.25 mg/kg body weight. All the animals were treated orally for 10 days. The animals were sacrificed on day 11, blood, liver and kidneys were removed and preserved for biochemical analyses. The liver samples were digested with mixture of concentrated trioxonitrate (V) acid (HNO3) and hydrochloric acid (HCl) (1:4 v/v). Cadmium concentrations in the liver were determined by atomic absorption spectroscopy (AAS). The concentrations of total plasma protein, albumin, uric acid and the activities of hepatic marker enzymes; alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyltransferase (GGT) were determined in the plasma and liver homogenates by standard procedures. The result of phytochemical screening revealed that flavonoids, tannins, terpenoids steroids, phlobatanins and saponins were present in the extract. The analysis by atomic absorption spectroscopy of the liver revealed that there were traces of cadmium (0.01 μg/g) in the liver of animals pre-treated with vitamin E and Jatropha curcas extract while the concentration of cadmium in the liver of only cadmium group was 0.14 µg/g. Additionally, the activities of hepatic marker enzymes (AST, ALT, GGT) were elevated in cadmium only treated group but pretreatment with methanolic extract of Jatropha curcas reduced significantly (p<0.05) the activities of these enzymes. The total protein and uric acid concentrations were also significantly reduced in cadmium treated group when compared with the extract pre-treated group. Comparison of the activities of hepatic marker enzymes (ALT, AST and GGT) in vitamin E and Jatropha curcas extract pre-treated groups revealed that ALT, AST and GGT activities were not significantly different in these groups. Also, albumin and uric acid concentrations were not significantly different between the groups. The results of biochemical studies of blood samples and liver homogenates revealed significant increase in the levels of maker enzymes reflecting liver injury caused by cadmium while pre-treatment with Jatropha curcas extract reduced the activities of the enzymes. Oral administration of methanolic extract of Jatropha curcas at 300 mg/kg body weight in this study was able to reduce the hepatotoxic effects of cadmium toxicity at 1.25 mg/kg body weight. This suggests that methanolic leaf extract of Jatropha curcas might possess hepatoprotective effect. The results of this investigation has further confirmed the inherent therapeutic properties of Jatropha curcas and also justified its uses in traditional medicine to cure various ailments in

Evaluation of Antidiabetic and the Effect of Methanolic Leaf Extract of Jatropha curcas on Some Biochemical Parameters in Alloxan-induced Diabetic Male Albino Rats

Evaluation of Antidiabetic and the Effect of Methanolic Leaf Extract of Jatropha curcas on Some Biochemical Parameters in Alloxan-induced Diabetic Male Albino Rats