BackgroundElectrocardiograms (ECGs) are vital for diagnosing cardiac conditions but obtaining clean signals in Left Ventricular Assist Device (LVAD) patients is hindered by electromagnetic interference (EMI). Traditional filters have limited efficacy. There is a current need for an easy and effective method. MethodsRaw ECG data obtained from 5 patients with LVADs. LVAD types included HeartMate II, III at multiple impeller speeds, and a case with HeartMate III and a ProtekDuo. ECG spectral profiles were examined ensuring the presence of diverse types of EMI in the study. ECGs were then processed with four denoising techniques: Moving Average Filter, Finite Impulse Response Filter, Fast Fourier Transform, and Discrete Wavelet Transform. ResultsDiscrete Wavelet Transform proved as the most promising method. It offered a one solution fits all, enabling automatic processing with minimal user input while preserving crucial high-frequency components and reducing LVAD EMI artifacts. ConclusionOur study demonstrates the practicality and efficiency of Discrete Wavelet Transform in obtaining high-fidelity ECGs in LVAD patients. This method could enhance clinical diagnosis and monitoring.