Jackfruit Research Articles

Nutritional composition and anti-nutritional properties of wild edible fruits of northeast India

Forageable fruits are an untapped wealth of nutrients and minerals, and huge numbers are found in the vast wilderness of northeast India, including the hilly state of Mizoram. However, their nutritional properties still need to be explored. Hence, the present study was carried to assess the nutritional and anti-nutritional aspects along with the mineral contents of seven selected wild edible fruits, viz. jackfruit (Artocarpus heterophyllus), rough lemon (Citrus jambhiri), false mangosteen (Garcinia xanthocymus), mulberry (Morus nigra), thereju (Prunus jenkinsiii), wild raspberry (Rubus treutleri) and wild ber (Zizyphus mauritiana) to uncover their immense nutritional values, which could solidify their promising potential for an alternate source of nutrition and increase their economic importance. The research demonstrates that Garcinia xanthocymus contains significant amount of total sugars, reducing sugars, and vitamin E. Artocarpus heterophyllus exhibited higher levels of non-reducing sugar, total soluble solids, chlorophyll, carbohydrate and starch. Citrus jambhiri is rich in moisture, vitamin C, acidity, N, and P. Prunus jenkinsii has high anthocyanin, total carotenoid, K and Mn. Rubus treutleri is a rich source of crude fibre, Mg, Na, Co, Cu, and Fe. Ziziphus mauritiana has higher protein. The Morus nigra has higher fat, energy, Ca, and Zn. These findings suggest that all examined wild edible fruits are rich in vitamins and minerals, which makes them vital in combating malnutrition and highlights their potential for use in the nutraceutical and pharmaceutical sectors in futuristic research works. The outcomes of this present study will provide a database about the nutritional composition, potential health benefits, and economic values of these fruits and raise public consciousness about the conservation and enrichment of biodiversity.

CAN THE APPLICATION OF AGROFORESTRY AT MONOCULTURAL FOOD CROP AREAS SUPPORT MANUFACTURER CHEMICAL FERTILIZER REDUCTION PROGRAMS WITHOUT SACRIFICING FARMERS' INCOME?

In an agroforestry system, nutrients from the subsoil can be made available to food plants through the absorption process by trees with deep roots. However, shade from canopy tree plants can suppress photosynthesis and reduce food crop production and farmer income [INCM]. This antagonism needs to be evaluated when introducing agroforestry programs into monoculture food crop areas to reduce manufactured chemical fertilizers application. This research was carried out from June to August 2023 at Natar District, South Lampung Regency to determine the effect of tree strata (teak, acacia, and albizia), multi-proposed tree species or MPTS (Parkia speciosa, avocado, and jack fruit), shrubs (coffee and cacao), and ground cover (vegetables, peanut, and soybean) to [INCM]. Interviewing forty respondents who were still retaining one or more of these tree strata among food crops including upland rice, corn, and cassava. The OLS (ordinary least square) model was employed at 90% confidence level. To eliminate the model error, the variables ownership of productive assets (upland, cattle, sheep, and cock), fertilizer application (urea, ponska, KCl and liquid fertilizer), compost, and pesticide use were also incorporated in the model. The results suggest the significant effects: (1) that positive ones are acacia, teak, vegetables, peanuts, and, soybeans, respectively USD 86.4 (P=0.000); 88.3 (P=0.000); 109,5 (P=0.000); 114.6 (P =0.000); 145.1 (P=0.000); and (2) which negative were Albizia falcataria, Parkia speciosa, avocado, coffee, and cacao respectively of around USD 31,7 (P=0.002); 57.1 (P=0.000); 43.2 (P=0.003); 62,0 (P=0.000) and 96.37 (P=0.000).

Morphological and genetic characterization of jackfruit (Artocarpus heterophyllus) in the Kayunga and Luwero districts of Uganda

BackgroundJackfruit (Artocarpus heterophyllus) is an economically valuable fruit tree in Uganda. However, the production of jackfruit in Uganda is low. Additionally, because of deforestation, genetic erosion of the resource is predicted before its exploitation for crop improvement and conservation. As a prerequisite for crop improvement and conservation, 100 A. heterophyllus tree isolates from the Kayunga and Luwero districts in Uganda were characterized using 16 morphological and 10 microsatellite markers.ResultsThe results from the morphological analysis revealed variations in tree height, diameter at breast height (DBH), and crown diameter, with coefficient of variation (CV) values of 20%, 41%, and 33%, respectively. Apart from the pulp taste, variation was also observed in qualitative traits, including tree vigor, trunk surface, branching density, tree growth habit, crown shape, leaf blade shape, fruit shape, fruit surface, flake shape, flake color, flake flavor and pulp consistency/texture. Genotyping revealed that the number of alleles amplified per microsatellite locus ranged from 2 to 5, with an average of 2.90 and a total of 29. The mean observed (Ho) and expected (He) heterozygosity were 0.71 and 0.57, respectively. Analysis of molecular variance (AMOVA) indicated that 81% of the variation occurred within individual trees, 19% among trees within populations and 0% between the two populations. The gene flow (Nm) in the two populations was 88.72. The results from the ‘partitioning around medoids’ (PAM), principal coordinate analysis (PCoA) and genetic cluster analysis further revealed no differentiation of the jackfruit populations. The Mantel test revealed a negligible correlation between the morphological and genetic distances.ConclusionsBoth morphological and genetic analyses revealed variation in jackfruit within a single interbreeding population. This diversity can be exploited to establish breeding and conservation strategies to increase the production of jackfruit and hence boost farmers’ incomes. However, selecting germplasm based on morphology alone may be misleading.

Activated carbon synthesized from Jack wood biochar for high performing biomass derived composite double layer supercapacitors

In this study, the electrochemical properties of bioderived activated carbon-based electrodes for supercapacitors formed using a sintered ceramic binder were investigated. Activated carbon derived from Jack wood tree (Artocarpus heterophyllus) with variable amounts of TiO2 nanoparticles as a binder, were used as electrodes in order to get good, activated carbon films on FTO substrates. No other binders were used in this study since most conventional binders devastate the electrical conductivity in the films. Furthermore, TiO2 has higher temperature tolerance compared to polymeric binders thus the electrode prepared can be used in wider applications. A series of electrochemical double-layer capacitors were fabricated and characterized by cyclic voltammetry and galvanostatic charge-discharge measurements. The supercapacitors prepared showed double-layer capacitive behavior. The electrodes that contain 90 % activated carbon and 10 % TiO2 show optimum performance along with an impressive specific capacitance of 147 F g−1 at 2 mV s−1 scan rate. This supercapacitor exhibits a power density of 68.5 W kg−1 while the energy density is 8.02 Wh kg−1. When the power density is as high as 1186.51 W kg−1 the energy density drops to 5.71 Wh kg−1. According to cyclic voltammetry measurements taken for 1000 cycles, the supercapacitor shows excellent cycle stability without any traces of capacitance drop.

Phytochemical screening, proximate and vitamin composition of Jack fruit (Artocarpus Heterophyllus) pulp and seed

The potential health benefits of plant are determined by the level of phytochemicals, proximate, minerals and vitamin composition of the plant material. The study was carried out to determine the phytochemical composition, proximate and vitamin content of Artocarpus heterophyllus pulp and seeds. The results revealed that Artocarpus heterophyllus is rich in phytochemicals such as Saponins, Alkaloid, Cardiac Glycoside, Phlobatannins, Terpenes, Steroids and Deoxy-Sugar. Proximate composition analysis indicated that the pulp has higher moisture, protein and lipid content, while crude fibre and carbohydrate were higher in the seed. The fruit pulp contained a greater percentage of vitamins A and C compared to the seeds. These phytochemicals, proximate composition, and vitamins offer numerous health benefits, suggesting that the consumption of jack fruit pulp and seeds may help in alleviating various health challenges.

Evaluation of the Antimicrobial and Antioxidant Activity of the Pulp of Artocarpus heterophyllus Lam (Moraceae)

Artocarpus heterophyllus Lam. (Moraceae) - Jackfruit beyond its culinary uses has been used to treat ailments ethnomedicinally. Its bark, leaves, seeds, and pulp are rich sources of bioactive compounds. This research aims to evaluate the antimicrobial and antioxidant activity of the pulp of the fruit; to identify the bioactive compounds present, that contributes these activities. The pulverised dried pulp was extracted using dichloromethane and methanol (1:1) and partitioned into respective fractions using n-hexane and methanol. Proximate analysis and Phytochemical screening were carried out using standard methods. Gas Chromatography - Mass Spectrometry (GC-MS) and Fourier Transform Infrared Spectroscopy (FTIR) were used for chemical profiling and detection of functional groups respectively. Antimicrobial activity testing was carried out, using the agar well diffusion assay. Antioxidant activity was evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Proximate analysis showed the presence of moisture (16.96%), fibre (20.89%), carbohydrate (50.63%), protein (7.20%), ash (2.26%), and lipid (2.06%). The phytochemical screening revealed the presence of alkaloids, flavonoids, phenolics, saponins, carbohydrates, proteins, tannins, steroids/triterpenoids and phlobatannins. Ten compounds were identified from the GC-MS Analysis. The pharmacologically active compounds were 9,12-octadecadienoic acid methyl ester, 9,12,15-octadecatrienoic acid methyl ester, 1-docosene, and lycopersene. FTIR analysis revealed the presence of aliphatic hydrocarbons (alkane, alkene) and oxygenated functional groups (hydroxyl, esters, aldehydes, ketones, ethers). The methanol, n-hexane fractions and total extract exhibited antimicrobial activity against Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. Regarding antioxidant activity, the methanol, n-hexane fractions and total extract showed IC50 values of 39.191 µg/ml, 102.5 µg/ml and 70.10 µg/ml respectively. The results of this study demonstrates that Artocarpus heterophyllus Lam. possesses significant antimicrobial and antioxidant properties due to the presence of bioactive compounds and holds promising implications for pharmaceutical applications.

POLA TANAM DAN SISTEM SILVIKULTUR PADA SKEMA PERHUTANAN SOSIAL DI KULON PROGO, D.I. YOGYAKARTA

Social forestry is a scheme chosen by the government to improve community welfare by providing legal access to communities to manage forests. One of the social forestry schemes implemented in Kulon Progo is Community Forestry. This scheme has great potential to be developed with a multi-use forestry management model. Therefore, a review of the silvicultural aspect is needed to understand the forest management model currently implemented. This research aims to identify tree species, planting patterns and silvicultural systems implemented by Community Forestry at Production Forests in Kulon Progo. The research was conducted from August to October 2023 in Plot 17 and Plot 19 of RPH Kokap, BDH Kulon Progo-Bantul. Observations were made by making measurement plots of 20 m x 40 m of each plot and then recording the name of tree species, coordinates, height, diameter, height without branches, and canopy width. The data were then analyzed using Spatially Explicit Individual-based Forest Simulator (SexI-FS) software version 2.1.0. to see the projected planting pattern. The results of the research showed that tree species planted in the Community Forestry were teak (Tectona grandis), acacia (Acacia mangium), mahogany (Swietenia macrophylla), eucalyptus (Eucalyptus sp.), paperback (Melaleuca leucadendron), and jackfruit (Artocarpus heterophyllus ). These species were planted using a mixed planting pattern with the silviculture system of selective logging with artificial regeneration.

Highly efficient hydrophobic nanocomposite in the decontamination of micropollutants and bacteria from aqueous wastes: A sustainable approach

Micro-pollutants (specifically antibiotics and personal care products) and potential bacterial contamination pose a severe threat to human health and marine life. The study derives indigenous novel fibrous hydrophobic nanocomposite, efficient in decontaminating the micro-pollutants (tetracycline (TC) and bisphenol A (BPA)) and potential pathogens (S. pyogenes and E. coli) from aqueous wastes. A facile method synthesizes the fibrous attapulgite (ATP)- poly(4-vinylpyridine-co-styrene) (PVP) framework decorated in situ with the Ag0 nanoparticles (ATP@PVP/Ag0). A greener method using the Artocarpus heterophyllus leaf extract derives the Ag0(NPs). Various analytical methods extensively characterize the materials. A comprehensive study that includes pH, concentration, background electrolytes, and ionic strength reveals the sorptive removal insights of TC and BPA utilizing the ATP@PVP solid. The elimination of tetracycline (TC) and bisphenol A (BPA) agrees well with the pseudo-second-order kinetics. The pH 3.07 and 6.06 favor removing TC and BPA with the capacity of 10.86 mg/g and 17.36 mg/g at 25 °C. The hydrogen bonding and hydrophobic interactions predominate the sorption mechanism, and the material shows remarkable stability and reusability in repeated sorption/desorption operations. Similarly, the natural water implications and flow-bed system show fair applicability of solid in decontaminating the TC and BPA in an aqueous medium. Further, the material ATP@PVP/Ag0 exhibits very high inhibition of potential pathogens S. pyogenes and E. coli and optimizes the solid dose and solution pH.

Statistical optimized production of Phytase from Hanseniaspora guilliermondii S1 and studies on purification, homology modelling and growth promotion effect

This investigation was performed to obtain a promising phytase enzyme producing yeast. In this regard, the PSM was used to isolate the phytase-producing Hanseniaspora guilliermondii S1 (MG663578) from sugarcane juice. The SSF optimum conditions for phytase generation were optimized using (OVAT) one-variable-at-a-time strategy using both Box-Behnken design and shake flask method (g/100 ml: 0.05 yeast extract, 0.15 Peptone, 0.05 malt extract 0.50 dextrose, pH 5.8 and 28ᵒC). The protein model developed was shown to be adequate for phytase production (91% accuracy), with the greatest phytase productivity in shake flask with substrate jack fruit seed powder being 395 ± 0.43 U/ml compared to 365U/ml for the BBD projected value. Crude Phytase was partially purified with a protein recovery of 43%, revealing a molecular weight of 120 kDa. It had an enzyme kinetic value of Km 3.3 mM and a Vmax of 19.1 mol/min. The 3D structure of PhyS1 amino acid sequences (PhyS1. B99990002) was simulated using Modeler 9.23, and the validated result revealed that 86.7% were in the favored region by Ramachandran plot. The SAVES server verified the 3D PDB file as satisfactory, and the model (in.pdb format) was uploaded in the PMDB database with the accession number ID: PM0082974. At the lab level, Hanseniaspora guilliermondii S1 (MG663578) producing phytase exhibited successful plant growth promotion activity in Ragi - CO 19 (Eleusine coracana L.) and Rice -Navarai - IR 64 (Oryza sativa L.). As a result, a phytase-based formulation for sustainable agriculture must be developed and tested on a large scale in diverse geographical areas of agricultural lands to determine its effect and potential on plant development.

Examining underutilized jackfruit (Artocarpus heterophyllus) seeds as a potential source of human subsistence in the Byse community, India

IntroductionThe seeds of jackfruit are often overlooked and discarded globally, leading to the underutilization of this valuable resource. This study explored the potential of utilizing underutilized jackfruit seeds as an alternative source of human subsistence by investigating the availability of jackfruit, the utilization and underutilization of seeds at the household level, and the types of subsistence activities in the community.MethodsWe used a case study of Byse village in Karnataka, India, to understand this topic. A mixed research approach was used. First, a descriptive research design was employed to collect and describe the data, while a correlation design was used to examine the relationships among variables related to jackfruit seed utilization. Second, a bibliometric analysis was conducted to explore global trends in jackfruit seed utilization.Results and DiscussionThe findings indicated that agriculture, particularly arecanut farming followed by paddy rice cultivation, was the primary means of subsistence in the community. While human consumption of jackfruit seeds is statistically significant, it has a detrimental effect on seed utilization in the community (r = −0.295, p = 0.008). The study also revealed that consuming jackfruit seeds in a semidry form had a positive and significant influence (r = 0.345, p = 0.002) compared to eating them in a fresh form. Consequently, more focus could be placed on encouraging the consumption of semidry jackfruit seeds as a preferred option among residents. Despite the abundance of jackfruits, their seeds are rarely used, with a mean utilization score of 1.77. Since jackfruit seeds are limited in their application and are readily available, they could be utilized as an alternative source for sustainable human subsistence. sustainable human subsistence.

Pantoea stewartii subsp. stewartii, the causative agent of Thai jackfruit’s bronzing disease and its possible host range in Vietnam

The bronzing disease of Thai jackfruit (Artocarpus heterophyllus Lam.) has recently appeared in Vietnam, causing a significant loss for farmers, but its control method is still restricted. In this study, we identified pathogens based on morphological and molecular characterizations. A total of 25 bacterial isolates were isolated from diseased samples. The bacterium produces white or yellow pigment in culture, is gram-negative, slightly pleomorphic, non-motile, facultatively anaerobic, short-rod, and catalase-positive. It hydrolyzes gelatin and starch but not tween 80, and produces acid from glucose, sucrose, and lactose. The bacterium does not produce indole and does not produce hypersensitivity to tobacco. The results of sequencing of the encoded region of synthesis of capsular polysaccharide (cpsD) and pathogenicity-related genes HrpS confirmed that the causative agent is Pantoea stewartii subsp. stewartii. The pathogen’s possible host range could be traditional jackfruit varieties, fruits, and crops such as durian, longan, mango, tomatoes, broccoli, pumpkin, cucumber, corn, rice, sweet potatoes, water spinach, peanuts, and green beans. The P. stewartii subsp. stewartii could enter the host plant cell through open wounds or natural openings such as stomata. The results confirmed the presence of P. stewartii subsp. stewartii in Vietnam and suggest that the jackfruit tree should not be planted in plantations with these crops to prevent cross-contamination and the spread of pathogens.

Termite Diversity and its Extent of Crop Damage in Vayalogam Soil Series of Tamil Nadu, India

A survey was conducted to study the distribution of termites in Vayalogam soil series, red sandy loam soil in Tamil Nadu, India. Among the termites collected from eleven places in Pudukottai district, Tamil Nadu all under one genera and three species, the predominant species was Odontotermus wallonensis (Wasmann) which was noticed in seven locations followed by O. assmuthi in three locations and O.obesus in one location. Further, an abundance of O. wallonensis was high (64.64%) followed by O. assmuthi (27.27%.) and O. obesus (9.90%.). The termite, O. wallonensis was recorded more in moundscompared to O. assmuthi and O. obesus, whereas in tree wood logs, three termite species were found. Among the avenue trees, pungam recorded less damage (7.25%) followed by jack trees (10.25%), Polyalthia (15.50%), tamarind (23.50%) and neem and eucalyptus (32.55 and 37.50%). In field crops termite damage was less in maize (5.75%), groundnut (10.25 %), and sugarcane (10.25%). The highest damage was recorded in jack fruit at seedling stage (46.50%) cultivated in Vayalogam soil series. The termite attack was not observed in field crops viz., pulses, castor, brinjal and chilli. termite species

Minerals, Amino Acids and Essential Oil Contents of Ethanol Extracts from Seeds and Pulps of Artocarpus Heterophyllus

Minerals, Amino Acids and Essential Oil Contents of Ethanol Extracts from Seeds and Pulps of Artocarpus Heterophyllus

Ethnobotanical Study of Potential Food-Utilization of Shade and Undercover Vegetation in the Coffee Agroforestry Landscape, Kalibaru District, Banyuwangi Regency

Agroforestry is a cultivation system that integrates crops like coffee with various vegetation, as applied in the Kalibaru District. The local community utilizes an agroforestry system by combining shade and undercover plants that can be utilized as food. The objective of this study was to collect a diversity of edible vegetation and investigate the local utilization. Data was collected by vegetation analysis and ethnobotanical studies related to their use. The result showed that 22 species of shade plants and 22 species of undercover plants were edible. The highest use value of shade species in coffee agroforestry are Leucaena leucocephala, Musa paradisiaca, Syzygium aromaticum, Carica papaya, and Artocarpus heterophyllus. Meanwhile, the highest use values in undercover species are Capsicum frutescens, Manihot esculenta, Colocasia esculenta, and Maranta arundinacea. The highest index of cultural significance for shade species is shown in Carica papaya, Leucaena leucocephala, Parkia speciosa, and Musa paradisiaca. Meanwhile, the highest index of cultural significance for undercover species is C. frutescens, L. esculentum, P. amarylifolius, and C. longa. This area can support local food resources and serve as a means of cultural preservation.

Eksplorasi Tumbuhan dalam Ritual Mappacci Suku Bugis di Wajo: Memahami Kekayaan Etnobotani Budaya Lokal Masyarakat

Mappacci is one of a series of traditional wedding rituals of the Bugis tribe. This research aims to classify and identify various types of plants and the meaning of their use in the traditional rituals of the Bugis mappaci tribe. This research method is descriptive qualitative. Data collection through observation, interviews and documentation. The results of the research found 7 types of plants in the Mappacci traditional ritual. The plant species used are Pacar (Lawsonia inermis L), Jackfruit (Artocarpus heterophyllus Lam), Banana (Musa paradisiaca L), Rice (Oryza sativa L), Coconut (Cocos nucifera L), Palm (Arenga pinnata Merr) and Cotton (Ceiba pentandra) which includes 6 families, namely Lythraceae, Moraceae, Musaceae, Poaceae, Arecaceae, Bombacaceae. The plant parts used are leaves (75%), fruit (50%), seeds (25%), sap (25%). The plants used in the Mappacci traditional rituals of the Bugis tribe have a philosophical meaning of goodness. Community knowledge in the use of these plants is a tradition passed down from generation to generation from their ancestors

Characteristics of Fruit Leather Made from Jackfruit (Artocarpus heterophyllus) with the Addition of Gracilaria sp. Agar Flour

Fruit leather is a food modification of semi-wet or dry processed fruit products in the form of thin sheets. Agar flour from seaweed Gracilaria sp. Can be used to improve the texture of fruit leather so that it is easy to consume. The aim of this research was to determine the role of agar powder from Gracilaria sp. in improving the texture of fruit leather and the influence on consumer preference value. The research method used is experimental laboratories. Making fruit leather using jackfruit then adding agar flour from Gracilaria sp. using control concentrations, 0.5%, 1%, 1.5%, and 2%. Testing of jackfruit fruit leather includes total sugar, water content, pH, ash content, texture and hedonic test. The results showed that the addition of Gracilaria sp agar powder had significant effect on all fruit leather parameters. The addition of 0.5% Gracilaria sp agar flour produced the best fruit leather.

Experimental investigation of diethyl ether (DEE) blended jack fruit peel oil (JFP) with hydrogen as a secondary fuel in dual-fuel compression ignition engines.

Jack fruit peel oil (JFPO) exhibits passive chemical characteristics; thereby, dual-fuel mode frequently involves hydrogen to address its combustion difficulties. This strategy has been gaining prominence nowadays. The present investigation investigates on the performance, emission, and combustion characteristics of a direct injected compression ignition dual-fuel engine operating on a binary fuel blend of jack fruit peel oil (JFPO) and diethyl ether with hydrogen induction. The engine was operated by inducing hydrogen gas into the intake manifold of the engine at 8 and 10 LPM with the applied load ranging from 25 to 100%. The test fuel was prepared by blending jack fruit peel oil and diethyl ether in the volumetric ratio of 90:10. JFP brake thermal efficiency was 16% lower than diesel at full load but enhanced by 9% with direct hydrogen induction at a knock limit of 10 LPM and 23% with JFP + H2 + 10% DEE at maximum load. At maximum load, JFP + 10 LPM of hydrogen gas + 10% DEE produces 916ppm of NOx, which is 44.46% less than diesel. Furthermore, adding hydrogen gas and DEE to air fuel mixture decreased emissions of carbon monoxide and unburned hydrocarbon by 0.702% and 28.30% opa, respectively.

Mammalian maltase-glucoamylase and sucrase-isomaltase inhibitory effects of Artocarpus heterophyllus: An in vitro and in silico approach

Alpha-glucosidase (maltase, sucrase, isomaltase and glucoamylase) activities which are involved in carbohydrate metabolism are present in human intestinal maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI). Hence, these proteins are important targets to identify drugs against postprandial hyperglycemia thereby for diabetes. To find natural-based drugs against MGAM and SI, Artocarpus heterophyllus leaf was explored for MGAM and SI inhibition in in vitro and in silico. A. heterophyllus leaf aqueous active fraction (AHL-AAF) was prepared using Soxhlet extraction followed by silica column chromatography. The phytoconstituents of AHL-AAF were determined using LC-ESI-MS/MS. AHL-AAF showed dose-dependent and mixed inhibition against maltase (IC50 = 460 µg/ml; Ki = 300 µg/ml), glucoamylase (IC50 = 780 µg/ml; Ki = 480 µg/ml), sucrase (IC50 = 900 µg/ml, Ki = 504 µg/ml) and isomaltase (IC50 = 860 µg/ml, Ki = 400 µg/ml). AHL-AAF phytoconstituents interaction with N-terminal (Nt) and C-terminal (Ct) subunits of human MGAM and SI was analyzed using induced-fit docking, molecular dynamics (MD), and binding free energy calculation. In docking studies, rhamnosyl hexosyl methyl quercetin (RHMQ), P-coumaryl-O-16-hydroxy palmitic acid (PCHP), and spirostanol interacted with active site amino acids of human MGAM and SI. Among these RHMQ stably interacted with all the subunits (Nt-MGAM, Ct-MGAM, Nt-SI and Ct-SI) whereas PCHP with Ct-MGAM and Nt-SI during MD analysis. In molecular docking, the docking score of RHMQ with NtMGAM, CtMGAM, NtSI and CtSI was −8.48, −12.88, −11.98 and −11.37 kcal/mol. The docking score of PCHP for CtMGAM and NtSI was −8.59 and −8.4 kcal/mol, respectively. After MD simulation, the root mean square deviation (RMSD) and root mean square fluctuation (RMSF) values further confirmed the stable protein-ligand interaction. The RMSD value of all the complexes were around 2.5 Å and the corresponding RMSF values were also quite low. In MM/GBSA analysis, the involvement of Van der Waals and lipophilic energy in the protein/ligand interactions are understood. Further binding free energy for Nt-MGAM-PCHP, Nt-MGAM-RHMQ, Nt-SI-PCHP, Nt-SI-RHMQ, Ct-MGAM-PCHP, Ct-MGAM-RHMQ and Ct-SI-RHMQ complexes was found to be −24.94, −46.60, −46.56, −44.48, −40.3, −41.86 and −19.39 kcal/mol, respectively. Altogether, AHL-AAF showed inhibition of α-glucosidase activities of MGAM and SI. AHL-AAF could be further studied for its effect on diabetes in in vivo.

Phytochemical Composition and Medicinal Properties of Psidium guajava, Artocarpus heteorphyllus, Anona muricata and Passiflora edulis: A Critical Review

Artocarpus heterophyllus Lam, a part of the Moraceae family, is known by distinctive names in different districts over the globe. The jackfruit tree's significant alleviating impacts have made it a well-known choice for characteristic cures. Its bioactive compounds, counting lignans, flavones, and saponins, contribute to its momentous therapeutic properties, which incorporate anti-cancer, anti-ulcer, anti-hypertensive, and anti-aging impacts. As a result, the jackfruit tree holds awesome importance in conventional medication and characteristic mending hones. Guanabana, soursop, graviola, or Brazilian paw paw, scientifically known as A. muricata, is a plant native to Central America but can be found in abundance across Southeast Asia, South America, and the African rainforest.. This plant has appeared various advantageous properties counting anticancer, antiulcer, antidiabetic, antiprotozoal, antidiarrhea, antibacterial, antiviral, antihypertensive, and wound mending impacts. Psidium guajava includes a wealthy history of restorative employments, with all parts of the tree being esteemed for their helpful properties. From the takes off to the natural products, each component of Psidium guajava has been utilized for different wellbeing benefits throughout a long time. Its restorative centrality includes to the by and large significance of this tropical tree totally different societies and conventional hones. Energy natural products, which have a place to the sort Passiflora, comprise of around 450 species. Among them, Passiflora edulis is the foremost well-known and commonly utilized. Later thinks about have too highlighted its anti-inflammatory potential, especially within the frame of tea made from the imbued clears out. Passiflora alata and P. edulis have both found applications in various pharmaceutical arrangements and are broadly utilized within the nourishment industry. The anti-oxidant substances present in P. Edulis have sparked a growing interest in this plant. Even though it is important, no audit of this species has been included in the logical writing up to this point. The notable and recent literature on the botany, traditional uses, phytochemistry, pharmacological effects, and harmfulness of this ponder plant is surveyed and summarized here. This overview may prove beneficial for subsequent research aimed at misusing the beneficial attributes of this priceless, curative species.

Molecular modelling approaches can reveal the Molecular interactions established between antimalarial targets of hemozoin pathway and the organic phytochemicals of Artocarpus species.

Ayurveda, the traditional Indian medical system, has potential applications in early malaria treatment. In an in silico docking study, 50 phytochemicals from two plants Artocarpus lakoocha Roxb. (AL) And Artocarpus heterophyllus Lam. (AH), were examined for their interactions with anti-malarial proteins (PDB IDs: 3BWK, 3BPF, 1LF3). The nucleotide analogue Artemisinin, a current malaria treatment, served as a positive control. Result showed that phytochemicals from AL and AH exhibited binding affinities as high as -9.6 kcal/mol, respectively. Additionally, molecular dynamics simulation for Artocarpin: 3BPF demonstrated stable complexes over 100 ns. Notably, Artocarpin and Quercetin displayed higher binding affinities (up to -9.6 as well as -9.5 kcal/mol, respectively) compared to Artemisinin (-7.5 up to kcal/mol), have shown. Pharmacokinetic predictions indicated the compounds were likely non-carcinogenic, water-soluble and biologically safe. In-vitro analysis using β-Hematin assay supported these findings, suggesting the phytochemicals as Hemozoin pathway inhibitors.