Whereas modern medicine has enabled humans to live longer and more robust lives, recent years have seen a significant increase in chronic care costs. The prevention of threats to mobility is critical for chronic disease management. Researchers and physicians often analyze data from wearable motion sensor–based information systems (IS) to prevent falls. However, prior studies on fall prevention often achieve suboptimal performance because of their limited capacities in modeling data distributions. In this study, we adopt the computational design science paradigm to develop a novel fall prevention framework, which includes the hidden Markov model with generative adversarial network (HMM-GAN) that extracts temporal and sequential patterns from sensor signals and recognizes snippet states and a logistic regression that utilizes the snippet states and determines whether and when to trigger protective devices to prevent fall injuries. We evaluate the proposed framework against prevailing fall-prevention models and the HMM-GAN component against state-of-the-art sensor analytics models on large-scale data sets. Through an in-depth case study, we demonstrate how the proposed framework can lead to significantly reduced potentially catastrophic falls. Besides practical health information technology contributions, HMM-GAN offers methodological contributions to the IS knowledge base for scholars designing novel IT artifacts for healthcare applications.