The issue of the long-term Armenian-Azerbaijani conflict within the framework of the Nagorno-Karabakh region has been studied. The problem of the ethnic polemic of Nagorno-Karabakh as one of the main factors of the confrontation is considered, and the historical roots of its initiation are indicated. The issue of escalation between the Republic of Armenia and the Republic of Azerbaijan after the collapse of the Soviet Union at the end of the 1980s was analyzed and conclusions were drawn regarding a new wave of confrontation. The classification of official documents and materials for the analysis of the specified problem is given. The importance of the military conflict between Armenia and Azerbaijan due to the non-resolution of the Nagorno-Karabakh region issue is emphasized not only for the Central Asian region, but for the whole world. The interest of certain external players in the need to solve the Karabakh problem is considered. The role of international actors in the framework of indirect participation, as well as peacekeeping mission, arbitration, etc. is evaluated. The current state of the military conflict is determined. The chronology and course of hostilities between the Republic of Armenia and the Republic of Azerbaijan are analyzed. The latest events of the Armenian-Azerbaijani conflict in the Nagorno-Karabakh region are considered and the main points of the dynamics of the confrontation are shown, as well as the main decisions made as a result of the anti-terrorist operation of the Azerbaijani army in the Nagorno-Karabash region are highlighted. Possible ways to stabilize the situation and settle the Karabakh conflict are identified, the involvement of civil society and communities on both sides to resolve the interstate problem is especially emphasized, and the importance of a comprehensive solution to both the political and humanitarian aspects of the conflict is emphasized. A significant role in the stabilization of the Nagorno-Karabakh region is given to international organizations in the role of mediators and development of realistic and mutually acceptable solutions.