Synthesis Of Isoxazolines Research Articles

ChemInform Abstract: Synthesis of Isoxazoline N‐Oxides and Application in the Formal Synthesis of Dehydroclausenamide (VIII).

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Proline as Lewis Base Catalyst: Diastereoselective Synthesis of Isoxazoline-N-oxide through [3 + 2] Cycloaddition

A catalytic cascade synthesis of isoxazoline-N-oxide was developed through proline-catalyzed nitroalkene activation. A large substrate scope was obtained with good to excellent yields. Mechanistic studies revealed intramolecular cyclization as the rate-determining step, giving only trans isomers in all cases.

Convenient synthesis of isoxazolines via tandem isomerization of allyl compounds to vinylic derivatives and 1,3-dipolar cycloaddition of nitrile oxides to the vinylic compounds

A novel effective method for the synthesis of new isoxazolines via tandem isomerization of QCH(X)CHCH(Y) to QC(X)CHCH2(Y) (Q=RO, RS, R2N, R3Si, etc.; X=H, R, OR; Y=H, R; R=alkyl, aryl) catalyzed by ruthenium complexes and 1,3-dipolar cycloaddition of the latter compounds to arenenitrile oxides is presented. The cycloaddition of QCH(X)CHCH(Y) to 2,6-dichlorobenzonitrile oxide is also described. The regio- and stereoselectivity of the cycloaddition of nitrile oxide to allyl and 1-propenyl (vinylic in general) compounds is discussed.

ChemInform Abstract: Highly Enantioselective Synthesis of Isoxazoline N‐Oxides.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

General Method for the Synthesis of Isoxazoline N‐Oxides from Aliphatic Nitro Compounds.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

General Method for the Synthesis of Isoxazoline N-Oxides from Aliphatic Nitro Compounds

A method for the synthesis of isoxazolines N-oxides from primary aliphatic nitro compounds and olefins based on the 1,3-dipolar cycloaddition of intermediate 1-halo-substituted silyl nitronates, followed by halosilane elimination has been described. The nature of the halogen atom plays a key role in determining the stability and reactivity of all intermediates of this process. Bromonitro compounds can be conveniently used in reactions with terminal alkenes, while fluorinated derivatives must be employed for internal olefins.

Nitrile oxides cycloadditions to PEG-bounded alkene dipolarophiles

A general method for the liquid-phase synthesis of isoxazolines through a 1,3-dipolar cycloaddition is described. The poly (ethylene glycol) (PEG)-supported acrylate ( 2) or methyl acrylate ( 6) reacted with nitrile oxides generated in situ from aldoximes 3, followed by cleavage from the PEG, to give isoxazolines in good yield and purity.

One-pot synthesis of isoxazolines and isoxazoles using soluble polymer-supported aldehyde

Liquid-phase synthesis of isoxazoles and isoxazolines through a 1,3-dipolar of nitrile oxides is described. Soluble polymer-supported nitrile oxides generated in situ react with dipolarophiles to afford isoxazoles and isoxazolines in good yields and purity.

New approach for the synthesis of isoxazoline-N-oxides.

A strategy for the synthesis of isoxazoline-N-oxides (cyclic five-membered nitronates) from primary nitro compounds and olefins is described. The key step of the process involves 1,3-dipolar cycloaddition of corresponding 1-bromosilyl nitronates with alkenes. [reaction: see text]

One‐pot Synthesis of Isoxazolines Using Soluble Polymer‐supported Acrylate

AbstractAn efficient liquid‐phase synthesis of isoxazolines through a 1,3‐dipolar cycloaddition is described. Soluble polymer‐supported acrylate reacted with nitrile oxides generated in‐situ, followed by cleavage from the support giving corresponding isoxazolines in high yields and excellent purities.

Stereoselective Electrophilic Cyclisation of O-Homoallyl Hydroxylamine Derivatives­

Electrophilic cyclisations of various O-homoallyl hydroxylamine derivatives are discussed. Non-protected O-homoallyl hydroxylamines undergo oxidative cyclisations to isoxazolines. The new isoxazoline synthesis comprises an initial electrophilic cyclisation to form intermediate isoxazolidines, which are subsequently oxidized to isoxazolines. Cyclisations can be conducted with various electrophiles (t-BuOCl, PhSeBr, NBS and NIS). Oxidation can be suppressed if the starting O-homoallyl hydroxylamines are N-sulfonylated. The electrophilic cyclisation then provides N-sulfonylated isoxazolidines with moderate cis-selectivity (up to 7:1). Electrophilic cyclisation of N-acylated O-homoallyl hydroxylamines provides isoxazolines or isoxazolidines depending on the reaction conditions (reagents). The t-BuOCl-mediated cyclisation affords isoxazolines via an oxidative cyclisation, whereas the NIS-induced reaction provides the 5-exo-cyclisation product with high stereoselectivity (cis:trans = 13:1).

ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Isoxazolines via Cycloaddition Reactions Using Pregnenolone as Chiral Auxiliary.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Solid-phase synthesis of isoxazolines.

The polymer-supported synthesis of isoxazolines is described via nitrile oxide intermediates, starting from primary nitroalkanes in a one-pot process.

Synthesis of Isoxazolines and Isoxazoles Using Poly(ethylene glycol) as Support

A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne 2 or alkene 6 reacted with nitrile oxides generated in situ from aldoximes 3, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.

ChemInform Abstract: Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

Precipitons-Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis.

Precipitons-Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis.

Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

Precipitons—Functional Protecting Groups to Facilitate Product Separation: Applications in Isoxazoline Synthesis

Solution-phase combinatorial synthesis of isoxazolines and isoxazoles using [2+3] cycloaddition reaction of nitrile oxides

An efficient way to construct a library of isoxazoles and isoxazolines was developed by solution-phase 1,3-dipolar cycloaddition reaction of nitrile oxides with olefins and alkynes followed by precipitation of the products as HCl salts.

ChemInform Abstract: A Facile and Novel Method for the Synthesis of 2‐Isoxazolines.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.