The TISOL thick target, on-line isotope separator is now operational at the TRIUMF facility with an active experimental program. A series of newly developed, target materials coupled with two different ion sources can now produce a wide range of isotopes. Radioactive beams of isotopes of He, C, N, O, Ne, Cl, Ar, Kr and Xe are now available in significant amounts from the first ECR (electron cyclotron resonance) ion source directly coupled to a multipurpose ISOL device. In addition, a surface ionization source with good yields for radioactive isotopes of Li, Na, Al, Ga, Rb, In, Cs, Yb and Fr is also available. Special emphasis has been given to the development of target materials, in particular light mass powder or pellet targets such as SiC and MgO. In addition, a newly developed zeolite (NaSiAlO 4) target shows properties which make it an optimal choice for producing isotopes near stability for nuclear astrophysics experiments with accelerated radioactive beams. Source and target developments at the upgraded TISOL facility will be presented.