In the last 10–15 years of intensive research on basically new approaches to isotope separation by isotope-selective excitation of atoms and molecules of the required isotope composition and by subsequent photophysical or photochemical conversion of the excited particles, there have been found new specific techniques which provide all the parameters required for the elementary separation event: separation coefficients, energy consumption, yield of the process, etc. The broad spectrum of these new techniques in principle even now makes it possible to reliably plan a laser technique for the isotope separation of almost any element of the periodic system. A successfully concluded stage of search investigations has led to a stage of developing complete laser separation processes, establishing similarity laws, and building pilot plants for isotopes to which the new techniques are indicated for economic reasons or other reasons. Interest is focused now upon the additional requirements, namely the cost of the initial raw materials, the consumption of energy for preparing the material to be irradiated in the required state (chemical compounds of specific type, state of aggregation of the material), the efficiency and safety of the chemical treatment of the enriched material, the capital expenditures for building the lasers needed, the reliability of their operation, etc. The laser-induced isotope separation techniques described make use of three different types of lasers with a high pulse repetition frequency; these lasers can be termed the laser basis for the corresponding separation techniques: dye lasers of the visible range, UV excimer lasers, and IR CO2 lasers in combination with various frequency conversion techniques. To the extent to which these laser types can be converted into highly reliable systems with an average power in excess of 1 kW, the time of the industrial use of the laser-induced isotope separation techniques described is approached.