This paper explores graph-theoretic polynomials to find the approximate solution of the (2+1)D Time-fractional Zakharov-Kuznetsov(TF-Z-K) equation. The Zakharov-Kuznetsov equations govern the behavior of nonlinear acoustic waves in the plasma of hot isothermal electrons and cold ions in the presence of a homogeneous magnetic field. Independence polynomials of the Ladder-Rung graph serve as the polynomial approximation for the suggested Independence Polynomial Collocation Method (IPCM). The Caputo fractional derivatives are adopted to determine the fractional derivatives in the TF-Z-K equation. The TF-Z-K equation is converted into a system of nonlinear algebraic equations using the collocation points in IPCM. The Newton-Raphson approach yields the solution of the suggested method by solving the resulting system. We’ve compared a few scenarios with the tangible outcomes to validate the procedure. Quantitative outcomes match the current findings and validate the exactness of IPCM compared t o the recent numerical and semi-analytical approaches in the literature.