The main chain of SW–NE-striking Cenozoic half-grabens of the Baikal rift zone (BRZ) follows the frontal parts of Early Paleozoic thrusts, which have northwestern and northern vergency. Most of the large rift half-grabens are bounded by normal faults at the northwestern and northern sides. We suggest that the rift basins were formed as a result of transformation of ancient thrusts into normal listric faults during Cenozoic extension. Seismic velocities in the uppermost mantle beneath the whole rift zone are less than those in the mantle beneath the platform. This suggests thinning of the lithosphere under the rift zone by asthenosphere upwarp. The geometry of this upwarp and the southeastward spread of its material control the crustal extension in the rift zone. This NW–SE extension cannot be blocked by SW–NE compression generated by pressure from the Indian lithospheric block against Central Asia. The geochemical and isotopic data from Late Cenozoic volcanics suggest that the hot material in the asthenospheric upwarp is probably provided by mantle plumes. To distinguish and locate these plumes, we use regional isostatic gravity anomalies, calculated under the assumption that topography is only partially compensated by Moho depth variations. Variations of the lithosphere–asthenosphere discontinuity depth play a significant role in isostatic compensation. We construct three-dimensional gravity models of the plume tails. The results of this analysis of the gravity field are in agreement with the seismic data: the group velocities of long-period Rayleigh waves are reduced in the areas where most of the recognized plumes are located, and azimuthal seismic anisotropy shows that these plumes influence the flow directions in the mantle above their tails. The Baikal rift formation, like the Kenya, Rio Grande, and Rhine continental rifts [Achauer, U., Granet, M., 1997. Complexity of continental rifts as revealed by seismic tomography and gravity modeling. In: Jacob, A.W.B., Delvaux, D., Khan, M.A. (Eds.), Lithosphere Structure, Evolution and Sedimentation in Continental Rifts. Proceedings of the IGCP 400 Meeting, Dublin, March 20–22, 1997. Institute of Advanced Studies, Dublin, pp. 161–171], is controlled by the three following factors: (i) mantle plumes, (ii) older (prerift) linear lithosphere structures favorably positioned relative to the plumes, and (iii) favorable orientation of the far-field forces.