Objective To evaluate the efficacy of anesthesia with general anesthesia combined with brachial plexus block in shoulder arthroscopy.Methods Forty-four patients (ASA Ⅰ or Ⅱ,aged 35 y-65 y,undergoing shoulder arthroscopy) were randomized into group A and B (n=22,each).While both groups having received inhalation-intravenous general anesthesia (GA),group B also received ultrasound-guided interscalene brachial plexus block with 0.2% ropivacaine 20 ml before GA.The HR,SBP,DBP and MAP at entering operation room,before skin incision,at skin incision,30,60,90 min after skin incision,and 30 min after tracheal extubation,the use of sufentanyl,rocuronium,isosorbide dinitrate and esmolol,and SaO2,PaO2 and PaCO2 before and after surgery,and the spontaneous respiration regaining time,tracheal extubation time and fully consciousness regaining time,and the visual analog scale (VAS) of pain,analgesics application and complications in the PACU were recorded.Results The HR and MAP at skin incision,and the minimum alveolar concentration (MAC) of sevoflurane and dosage per weight of sufentanyl in group A and B were (68±11) bpm and (63±7) bpm,(86±15) mm Hg and (69±10) mm Hg(1 mm Hg=0.133 kPa),(1.28±0.21) MAC and (1.08±0.20) MAC,(0.54±0.08) μg/kg and(0.34±0.06) μg/kg,respectively(P<0.001).The cases that needed esmolol or isosorbide dinitrate,the post-operation PaCO2 and the tracheal extubation time in group A and B were 12 and 2 cases,(13±10) min and (7±4)min,(44±3) mm Hg and (42±3) mm Hg,respectively (P<0.05).The pain VAS of group A and B were (4±2) and (0±2),respectively (P<0.001).There were no significant statistic differences between the two groups in relevant complications (P>0.05).Conclusions Brachial plexus block combined with general anesthesia enhances the anesthesia quality in shoulder arthroscopy,which not only reduces the fluctuation of blood pressure,decreases the use of narcotic analgesics and short-acting antihypertensive agents,but also shortens the tracheal extubation time,and has short-time postoperative analgesic effect and no severe complications. Key words: Shoulder arthroscopy; Brachial plexus nerve block; General anesthesia; Anesthesia quality