Isoquinoline Scaffold Research Articles

5,6-Dihydropyrrolo[2,1- b]isoquinolines as scaffolds for synthesis of lamellarin analogues

Efficient modular synthetic routes to open chain marine alkaloids such as lamellarins have been developed. 5,6-Dihydropyrrolo[2,1- b]isoquinoline scaffolds were prepared, and protocols enabling regioselective bromination followed by Suzuki cross-coupling were established for the introduction of aryl groups onto the 2- and 3-positions.

Concise synthesis of isoquinoline via the Ugi and Heck reactions.

[reaction: see text] Two types of isoquinoline scaffolds were successfully constructed in a combinatorial format via the Ugi four-component reaction and the Pd-catalyzed intramolecular Heck reaction, starting from readily available starting materials.