Isopropyl Derivatives Research Articles

The camphenehydro (methylcamphenilyl) and isobornyl (bornyl) cations. I. Generation of the enantiomeric cations by the π- and σ-routes of solvolysis

The acetolysis of α-campholenyl [2-(2',3',3'-trimethylcyclopent-3'-enyl)] p-nitrobenzenesulphonate proceeds with π-bond participation to give cyclized products (99.7%) derived from the equilibrating classical camphene hydro and isopropyl cations. The composition of the product is similar, but not identical, to those formed by the σ-route from the acetolysis of suitable isopropyl and bornyl derivatives. When α-campholenyl p-nitrobenzenesulphonate and the isopropyl derivatives are prepared from (+)-camphor, the two enantiomers of camphene having high optical purities are formed. A simple procedure for the preparation of camphene of high optical purity from isoborneol is described.

NMR spectra of monosubstituted alkanes. II isopropyl derivatives

NMR spectra of monosubstituted alkanes. II isopropyl derivatives

Kinetics of nucleophilic substitution of α-halogeno-sulphoxides

α-Halogenomethyl sulphoxides react with PrnO– and EtS– in PrnOH via SN2 substitution; α0halogenoethyl and isopropyl derivatives react more slowly: SN2 reactions are greatly retarded by steric effects and SN1 reactions by the effect of the SO group.

Propyl and isopropyl derivatives of 2,2'-hydrazopyrimidines. 5. Condensation with hydrazine-N,N'-dicarbonic acid diamidine

AbstractDie Kondensation des Hydrazin‐N,N′‐dicarbonsäure‐diamidins (I) mit β‐Diketonen (II) führt unter Verwendung von wäßrig‐alkoholischer Natronlauge als Reaktionsmedium bei Raumtemperatur zu 2,2′‐Hydrazopyrimidinen (III). Die neuen Substanzen sind durch die N,N′‐Diacetylderivate (IV) und durch die IR‐ und NMR‐Spektren charakterisiert worden.

C-13 Resonance Chemical Shift for Substituted Ethyl and Isopropyl Derivatives

C-13 Resonance Chemical Shift for Substituted Ethyl and Isopropyl Derivatives

Antioxidants. XVII. The synthesis of ethyl, isopropyl, tert-dodecyl and phenyl derivatives of 4,4'-isopropylidenebisphenol

Antioxidants. XVII. The synthesis of ethyl, isopropyl, tert-dodecyl and phenyl derivatives of 4,4'-isopropylidenebisphenol

Monoamine Oxidase Inhibitors. Synthesis of a Series of Isopropylidine and Isopropyl Derivatives of Some Aryl and Arylalkyl Acid Hydrazides

Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum-on-charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α-naphthoic acid, β-naphthoic acid, α-naphthylacetic acid, and β-naphthylacetic acid. Six isopropylidene hydrazides and six isopropyl hydrazides were prepared. This investigation was undertaken since recent derivatives of hydrazines and hydrazides have shown considerable activity as monoamine oxidase inhibitors. The hydrazides were synthesized from the aryl and arylalkylesters and hydrazine. From these hydrazides the isopropylidene derivatives were prepared by refluxing with acetone. Reduction of the isopropylidene hydrazides, using hydrogen and 5 per cent platinum-on-charcoal catalyst, gave the isopropyl hydrazides. The hydrazides prepared were of benzoic acid, phenylacetic acid, α-naphthoic acid, β-naphthoic acid, α-naphthylacetic acid, and β-naphthylacetic acid.

NMR Spectra of Some Cyclohexyl Derivatives

In order to determine the C–C bond chemical shift in a new series of substituted hydrocarbons, the chemical shifts of the α protons in a series of monosubstituted cyclohexanes have been studied. Where possible each sample was frozen into its individual conformers in order to account for varying stereochemical influences. The derived values of the C–C bond shifts are in good agreement with the values found for corresponding ethyl and isopropyl derivatives.

Notes- Preparation of 1-Phenyl-2-methyl-2-hydrazinopropane Hydrochloride and Its Isopropyl Derivatives

Notes- Preparation of 1-Phenyl-2-methyl-2-hydrazinopropane Hydrochloride and Its Isopropyl Derivatives

Proton Chemical Shifts for the Alkyl Derivatives

The chemical shifts of a series of methyl, ethyl, propyl, and isopropyl derivatives have been studied in an effort to determine the distance and angular dependence of any contribution to the chemical shift arising from magnetically anisotropic substituent groups. It was found that electron withdrawal effects play a dominant role in determining the chemical shifts for methyl derivatives. The nearly exactly linear relation of the methyl shifts to electronegativity for the methyl halides seems to rule out any large influence due to magnetic anisotropy. The ethyl shifts were found to be determined by electron withdrawal effects plus a factor which acted equally at the α and β positions. It was found that this factor arises from the carbon-carbon bond. By assigning a chemical shift due to the presence of the C–C bond, which is dependent in size on the substituent attached to the α carbon, the apparently anomalous frequencies observed for the alkyl derivatives can be accounted for. A possible explanation for the C–C bond shift may be regular changes in the paramagnetic term in the Ramsey equation due to changes in the excitation energy denominator when a C–C bond replaces a C–H bond.

Isoniazid and ocular tuberculosis; an evaluation of experimental and clinical studies.

Isoniazid (isonicotinic acid hydrazide, known by the trade names of Nydrazid and I. N. H.) first attained prominence in the literature in 1952, at which time multiple studies were reported on its effectiveness, experimentally and clinically, in the therapy of pulmonary and other forms of tuberculosis.* Isoniazid is a white, crystalline solid, freely soluble in water at any pH. It is poorly soluble in the common inert organic solvents, such as ethanol, ether, and benzene. In a dry state and in neutral and acid aqueous solutions, it is stable at room temperatures. Biological fluids, feces, and aqueous solutions containing isoniazid can be autoclaved for one hour at 15 lb. of pressure without destruction of the isoniazid in them provided the material is made acid before heating.16 From the reports16on toxicity studies in several species of animals, it has been shown that both isoniazid and its isopropyl derivatives

Tolerance of Macacus Rhesus for Isonicotinylhydrazines: A Preliminary Report

Macacus rhesus monkeys tolerate isonicotinylhydrazine and its glucosyl and isopropyl derivatives administered serially over prolonged periods and in doses sufficiently high to expect a possible antituberculous activity.