The yield of γ-rays from the reaction 49Ti(p, γ) 50V has been measured as a function of bombarding energy over the range 0.74–2.27 MeV and the yield of neutrons from the reaction 49Ti(p, n) 49V has been measured from threshold to a bombarding energy of 3.25 MeV. Strong competition effects were observed in the γ-ray yield at the opening of the neutron channel. The energy dependence of these cross sections is compared with statistical-model calculations, and good agreement is achieved. Thermonuclear reaction rates are calculated for the temperature range 5 × 10 8–5 × 10 9 K which includes the range of temperatures of interest in nucleosysnthesis calculations. The effect of a strong isobaric analogue resonance on the (p, γ) thermonuclear reaction rate is identified and its importance is discussed.